2006
DOI: 10.1158/1078-0432.ccr-06-0130
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DNA Integrity Assay: A Plasma-Based Screening Tool for the Detection of Prostate Cancer

Abstract: Purpose: The aim of this study was to evaluate the utility of the DNA integrity assay (DIA) as a plasma-based screening tool for the detection of prostate cancer. Experimental Design: Blood samples were collected from patients with biopsy-proven prostate cancer prior to prostatectomy (n = 123) and processed as two-spin plasma preparations. The three control groups included: males <40 years old with no history of cancer (group 1, n = 20); cancer-free postprostatectomy patients (group 2, n = 25), and patients wi… Show more

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Cited by 50 publications
(30 citation statements)
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“…In support to this hypothesis, recent studies demonstrated increased DNA length in plasma from patients with breast [5] and gynecologic cancers in comparison to healthy subjects [6]. Moreover, DNA characterized by higher integrity could be evidenced in cancer of the head and neck [7], prostate [8], kidney [9,10], esophagus [11], nasopharynx [12] and colon [13]. The test is based on the hypothesis that DNA fragments in plasma of cancer patients are longer than those detectable in healthy individuals.…”
Section: Introductionmentioning
confidence: 86%
“…In support to this hypothesis, recent studies demonstrated increased DNA length in plasma from patients with breast [5] and gynecologic cancers in comparison to healthy subjects [6]. Moreover, DNA characterized by higher integrity could be evidenced in cancer of the head and neck [7], prostate [8], kidney [9,10], esophagus [11], nasopharynx [12] and colon [13]. The test is based on the hypothesis that DNA fragments in plasma of cancer patients are longer than those detectable in healthy individuals.…”
Section: Introductionmentioning
confidence: 86%
“…It was seen that the DNA integrity was higher in PCA patients than in controls [85]. Ellinger et al demonstrated that the DNA integrity was a predictor of PSA recurrence following radical prostatectomy and that the DNA integrity may allow to recognize PCA patients and benign prostate hyperplasia patients with a specificity of 81% and a sensitivity of 68% [77].…”
Section: Prostate Cancermentioning
confidence: 99%
“…In this context, the detection and characterization of cell-free DNA in the peripheral blood from tumor patients have attracted great interest in biomedical research. Until now, only few studies have been conducted to explore the prognostic potential of cell-free DNA in prostate cancer (Chun et al 2006;Hanley et al 2006).…”
Section: Introductionmentioning
confidence: 99%