DNA-functionalized colloidal crystals for macromolecular encapsulation

Yokomori, Maasa; Suzuki, Hayato; Nakamura, Akiyoshi; Sugano, Shigeo S.; Tagawa, Miho

doi:10.1039/d2sm00949h

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Another interesting direction is the combination of DNA-modified NG with other processing technologies such as metallization, [21] silicification, [139,140] and lithography. [85,141] Further integrating other tools such as biomolecule interaction and protein functional analysis, [142][143][144] a feasible methodology could be established in the manufacture of diverse hybrid materials and nanophotonic devices. A more futuristic direction is to build dynamic NG arrays, rapid prototyping or even nano-factories on a chip that work like photosynthesis systems and living cells.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Dynamic Gold Nanostructures Based on DNA Self Assembly

Kou,

Wang,

Mousavi

et al. 2023

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The combination of DNA nanotechnology and Nano Gold (NG) plasmon has opened exciting possibilities for a new generation of functional plasmonic systems that exhibit tailored optical properties and find utility in various applications. In this review, the booming development of dynamic gold nanostructures are summarized, which are formed by DNA self‐assembly using DNA‐modified NG, DNA frameworks, and various driving forces. The utilization of bottom‐up strategies enables precise control over the assembly of reversible and dynamic aggregations, nano‐switcher structures, and robotic nanomachines capable of undergoing on‐demand, reversible structural changes that profoundly impact their properties. Benefiting from the vast design possibilities, complete addressability, and sub‐10 nm resolution, DNA duplexes, tiles, single‐stranded tiles and origami structures serve as excellent platforms for constructing diverse 3D reconfigurable plasmonic nanostructures with tailored optical properties. Leveraging the responsive nature of DNA interactions, the fabrication of dynamic assemblies of NG becomes readily achievable, and environmental stimulation can be harnessed as a driving force for the nanomotors. It is envisioned that intelligent DNA‐assembled NG nanodevices will assume increasingly important roles in the realms of biological, biomedical, and nanomechanical studies, opening a new avenue toward exploration and innovation.

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Section: Conclusion and Prospectsmentioning

confidence: 99%

Dynamic Gold Nanostructures Based on DNA Self Assembly

Kou,

Wang,

Mousavi

et al. 2023

Small

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“…Therefore, the DNAbased protocols need to amplify the signal again. Fortunately, DNA can link with AuNPs to form one-dimensional (1D) [46,47], twodimensional (2D) [48,49], and three-dimensional (3D) [50] DNA-AuNPs nanostructure including AuNP triangles [51], AuNP squares [52], AuNP clusters [53], AuNP cages [54]. The nanostructure of DNA-AuNPs did not only provide more binding sites on the surface of nanoparticles and reduce non-specific background amplification, but also can prevent AuNPs aggregating to improve the stability of AuNPs [55].…”

mentioning

confidence: 99%

A dual amplified gold nanoparticle‐based biosensor for ultrasensitive and selective detection of fibrin

Gong,

Zhang,

Chen

et al. 2024

Luminescence

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Ultrasensitive, selective, and non‐invasive detection of fibrin in human serum is critical for disease diagnosis. So far, the development of high‐performance and ultrasensitive biosensors maintains core challenges for biosensing. Herein, we designed a novel ribbon nanoprobe for ultrasensitive detection of fibrin. The probe contains gold nanoparticles (AuNPs) that can not only link with homing peptide Cys‐Arg‐Glu‐Lys‐Ala (CREKA) to recognize fibrin but also carry long DNA belts to form G‐quadruplex‐based DNAzyme, catalyzing the chemiluminescence of luminol–hydrogen peroxide (H2O2) reaction. Combined with the second amplification procedure of rolling circle amplification (RCA), the assay exhibits excellent sensitivity with a detection limit of 0.04 fmol L−1 fibrin based on the 3‐sigma. Furthermore, the biosensor shows high specificity on fibrin in samples because the structure of antibody‐fibrin‐homing peptide was employed to double recognize fibrin. Altogether, the simple and inexpensive approach may present a great potential for reliable detection of biomarkers.

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