Dna flow cytometry of stomach cancer. Prospective correlation with clinicopathologic findings

Lee, Kyoo Hyung; Lee, Jung Shin; Suh, Cheolwon; Ahn, Myung Ju; Kim, Sang We; Doh, R N Byung Soon; Min, Yong‐Ki; Kim, Byung Sik; Park, Kun Choon; Lee, In-Cheol; Cho, Young Joo; Choi, Mi Gyoung; Kim, Sanghee

doi:10.1002/1097-0142(19930915)72:6<1819::aid-cncr2820720605>3.0.co;2-6

Cited by 19 publications

(13 citation statements)

References 14 publications

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“…The results of the Trans-Tasman Radiation Oncology Group study (TROG) 99.02 also showed that T1-2 anal carcinomas require elective inguinal radiation treatment 32. Our study found that the 5-year actuarial rate of inguinal recurrence was 17.0%, which is consistent with previous reports 23. Inguinal lymph node treatment is necessary for patients with anal carcinoma.…”

Section: Discussionsupporting

confidence: 90%

“…The patients with positive inguinal lymph nodes had a poorer survival than those with negative inguinal lymph nodes (19.1% vs. 46.9%, respectively, p= 0.007). In previous studies, the risk for subclinical disease in the inguinal lymph nodes ranged from 18% to 28% 23. Therefore, we inferred that the inguinal lymph node is a high-risk region requiring significant clinical attention.…”

Section: Discussionmentioning

confidence: 80%

“…A report from the University of Florida stated that elective irradiation of the inguinal lymph nodes is highly effective in controlling subclinical disease from carcinomas originating in the pelvis. Further, the inguinal lymph node control rate was 96% and can be accomplished with minimal acute or long-term complications 23. Two recent studies have shown that with radiation to elective node irradiation, excellent nodal control was achieved in the inguinal region, with control rates as high as 98.5% and 100.0% 29, 30.…”

Section: Discussionmentioning

confidence: 96%

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Anal adenocarcinoma requires prophylactic inguinal nodal treatment: Results from a single Chinese institution

Guo

Mao

et al. 2017

J. Cancer

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Background: Literature pertaining to prophylactic inguinal nodal treatment for anal adenocarcinoma in China is scarce.Methods: In this retrospective study, we analyzed 126 patients from 1965 to 2015. Among these, 67 patients received surgery only, 18 patients received chemoradiotherapy only, 27 patients received a combination of both, and the remaining 14 patients received palliative treatment.Results: The median follow up period was 30 months. The 1-year, 3-year, and 5-year overall survival rates were 85.8%, 62.5%, and 43.4%, respectively. The 5-year overall survival was 46.9% for patients with negative inguinal lymph nodes and 19.1% for patients with positive inguinal lymph nodes (p=0.007). The overall 5-year inguinal node relapse-free survival was 83.0%. The 5-year inguinal node relapse-free survival was 87.5% for stage I, 86.9% for stage II, and 76.5% for stage III cancers. Among those with negative inguinal nodes, the 5-year inguinal node relapse-free survival was 85.7% for negative regional lymph nodes and 75.4% for positive regional lymph nodes (p=0.089).Conclusion: Inguinal lymph node is a high-risk subclinical area. Prophylactic inguinal nodal treatment is necessary for patients with anal adenocarcinoma irrespective of positive or negative inguinal lymph nodes.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 96%

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Anal adenocarcinoma requires prophylactic inguinal nodal treatment: Results from a single Chinese institution

Guo

Mao

et al. 2017

J. Cancer

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“…DNA ploidy and SPF were determined by DNA flow cytometry as previously described (Lee et al, 1993). Samples were frozen rapidly in polypropylene screw-cap tubes, and stored in a freezer at -80°C.…”

Section: Methodsmentioning

confidence: 99%

Prognostic value of DNA flow cytometry in stomach cancer: a 5-year prospective study

et al. 1999

Br J Cancer

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SummaryThe role of DNA flow cytometry in the prediction of prognosis for patients with stomach cancer remains to be defined. Thus we studied prospectively the role of DNA flow cytometry as a prognosis indicator in stomach cancer patients in a high-incidence area. Between November 1990 and December 1992, primary stomach cancer tissues were obtained from the surgical specimens from 217 patients (148 male, 69 female). DNA flow cytometric analyses of DNA ploidy and S-phase fraction were performed and the results were correlated with patient survival. The median age of the patients was 55 years (range 24-78). Aneuploid cell population was found in 114 of 217 samples (53%). Tumour S-phase fraction was obtained in 96 of 103 diploid tumours (93%) and 61 of 114 aneuploid tumours (54%). After median follow-up of 66.1 months, the patients with tumours with an S-phase fraction over 17% had significantly worse survival rates than patients with tumours with S-phase fractions of lower than 8% or 8-17% (45% vs 59% and 63% of patients surviving, P = 0.007). Tumour ploidy status did not correlate with patient survival. Multivariate analyses showed that the TNM stage remained the most important prognostic indicator. The tumour S-phase fraction was also an independent prognostic indicator (relative risk 2.300, 95% CI, 1.252-4.223). Tumour S-phase fraction obtained by DNA flow cytometry is an independent prognostic indicator for the survival of the patients with stomach cancer.

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“…Well-differentiated and moderately differentiated carcinomas display aneuploid patterns more frequently than poorly differentiated tumors [4, [42][43][44][45], though some reports have not agreed with that conclusion [36,46].…”

Section: Gastric Cancer and Dna Aneuploidymentioning

confidence: 99%

Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers

et al. 2012

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The biological characteristics of cancers depend mostly on genetic alterations in the cancer cells of individuals. Gastric cancers show a high frequency of DNA aneuploidy, a phenotype of chromosomal instability. Compared to diploid tumors, gastric carcinomas with aneuploidy have been shown to have high proliferative activity and high metastatic or invasive potential; these characteristics lead to a poor prognosis. It has been suggested that an abnormal spindle assembly checkpoint is involved in DNA aneuploidy, but the underlying mechanism is still unclear. This review, in order to determine whether gastric carcinomas that display aneuploidy are associated with a poorer prognosis than diploid tumors, and to discuss the biological mechanisms that induce aneuploidy, summarizes the results of studies on DNA ploidy in gastric cancer published in the English literature. Analysis of DNA ploidy in gastric cancer may provide clinically useful information from diagnostic, therapeutic, and prognostic standpoints. Further investigations may be needed to clarify the relationship between chromosome instability and DNA ploidy.

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Dna flow cytometry of stomach cancer. Prospective correlation with clinicopathologic findings

Cited by 19 publications

References 14 publications

Anal adenocarcinoma requires prophylactic inguinal nodal treatment: Results from a single Chinese institution

Anal adenocarcinoma requires prophylactic inguinal nodal treatment: Results from a single Chinese institution

Prognostic value of DNA flow cytometry in stomach cancer: a 5-year prospective study

Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers

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