DNA flow cytometric analysis indicates that many breast cancers detected in the first round of mammographic screening have a low malignant potential

Kallioniemi, Olli; Kärkkäinen, A; Auvinen, O; Mattila, Jouni; Koivula, Timo; Hakama, Matti

doi:10.1002/ijc.2910420511

Cited by 21 publications

(8 citation statements)

References 25 publications

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“…Results well in accordance with the present ones have been reported from a mammography based series (Kallioniemi et al, 1988), where 37 breast carcinomas found in mammography screening in 1984-87 were compared with 60 breast cancers detected clinically in two university hospitals in 1975-82. In this study DNA aneuploidy was observed in 46% of screen-detected and in 68% of clinically detected cancers, and the median SPF was significantly lower (3.5%) in screen-detected cancer than in the clinical controls (9.6%), which were, however, larger in size than the screendetected cancers.…”

Section: Discussionsupporting

confidence: 91%

Histological features, DNA content and prognosis of breast carcinoma found incidentally or in screening

Joensuu

Toikkanen²,

Klemi³

1991

Br J Cancer

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Summary Histology features, the nuclear DNA content and prognosis of 42 female breast carcinomas found in a physical examination based screening, 54 breast cancers found incidentally by medical personnel, and 274 breast cancers first suspected by the patient were compared. There was no significant difference in the distribution by primary tumour size (P = 0.08) or histological type (P = 0.87) of breast cancer between the screen-detected and 139 self-suspected cancers of women with similar mean age and living at the same time in the same city, but the screen-detected carcinomas were better differentiated (P = 0.0002), and had less mitoses (P =0.008), less tumour necrosis (P = 0.004) and DNA aneuploidy (P = 0.01), smaller S-phase fractions (P = 0.009), less axillary metastases (P = 0.04), and had better outcome (P = 0.005) than self-suspected carcinomas. These parameters did not differ significantly between the screen-detected and incidentally found cancers, but incidental cancers had more often axillary metastases (P = 0.02). The results indicate that screen-detected breast carcinomas have favourable biological features suggesting low degree of malignant potential.

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Section: Discussionsupporting

confidence: 91%

Histological features, DNA content and prognosis of breast carcinoma found incidentally or in screening

Joensuu

Toikkanen²,

Klemi³

1991

Br J Cancer

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“…[28][29][30] These tumours are more often ER and PR positive. We found that screen-detected/missed carcinomas were significantly more often ER positive in univariate analysis, a result that is confirmed by other studies.…”

Section: Discussionmentioning

confidence: 99%

Aggressiveness of ‘true’ interval invasive ductal carcinomas of the breast in postmenopausal women

et al. 2010

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There is debate whether interval carcinomas differ from screen-detected tumours biologically. In this study, clinico-pathological parameters and the expression of well-validated biological markers were compared between 'true' interval carcinomas and screen-detected/missed carcinomas hypothesising that 'true' interval carcinomas show a more aggressive biological behaviour. The study group consisted of 92 consecutive postmenopausal women attending the breast screening programme and presenting with an invasive ductal carcinoma. All screening mammograms were re-reviewed. Sixteen patients had a 'true' interval carcinoma. Seven carcinomas were missed at screening, but detected on re-reviewing of the screening mammogram. Radiological characteristics were assessed from diagnostic mammograms. Data on patient-and tumour characteristics and follow-up data were recorded from hospital records. Median follow-up was 61 months. Immunohistochemistry for ER, PR, Her2/neu and p53 was performed on TMA sections. Univariate and multivariate logistic regression analyses were performed. In univariate analysis, 'true' interval carcinomas were significantly larger (odd ratios (OR) 7.2, 95% CI 1.8-28.1) and less frequently ER (OR 0.3, 95% CI 0.1-0.9) and PR (OR 0.3, 95% CI 0.1-1.0) positive. In multivariate analysis, 'true' interval carcinoma was independently associated with larger tumours (OR 7.0,. A trend toward ER negativity was found (OR 0.3, 95% CI 0.1-1.1). 'True' interval carcinomas showed a trend toward a decreased relapse-free survival (HR 1.7 95% CI 0.9-3.1). Although 'true' interval carcinomas were significantly larger than screen-detected/missed interval carcinomas, it remains challenging to observe parameters that determine this difference between 'true' interval carcinomas and screen-detected lesions.

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“…Flow cytometric data have already suggested that small subclinical cancers have a slower growth rate than manifest cancer (Kallioniemi et al, 1988b).…”

Section: Markers In ' 'Subclinical' ' Cancersmentioning

confidence: 99%

Chapter I. Biology and natural history of breast cancer

Pontén

Holmberg²,

Trichopoulos³

et al. 1990

Int. J. Cancer

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DNA flow cytometric analysis indicates that many breast cancers detected in the first round of mammographic screening have a low malignant potential

Cited by 21 publications

References 25 publications

Histological features, DNA content and prognosis of breast carcinoma found incidentally or in screening

Histological features, DNA content and prognosis of breast carcinoma found incidentally or in screening

Aggressiveness of ‘true’ interval invasive ductal carcinomas of the breast in postmenopausal women

Chapter I. Biology and natural history of breast cancer

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