DNA damage protection: an excellent application of bioactive compounds

Abstract

Discovery of deoxyribonucleic acid (DNA) solved out the mystery of cellular functioning and abnormality in cellular metabolism. Understanding the coding of DNA resulted in enormous medical growth and helps the researchers in finding the genes which trigger major chronic diseases in humans. Further, the structural and sequential analysis brought humans into a new era of medical industry. The advancement in understanding of DNA could be a boon for agricultural sector as it allowed the farmers/breeders to choose better varieties with disease resistant features. In developing nations where the staple foods suffers with micronutrient deficiencies and stress conditions, DNA modifications and repair mechanism could solve out their problems. The role of DNA damaging factors and repair mechanism plays a crucial role in occurrence of certain disorders. Extracts prepared from various natural resources could either stop or slow down the process of DNA damage. This will help to eradicate major disorders related to DNA from human race. Further on the basis of type and dose of natural extracts, it would ease the planning of diets for patients suffering from chronic disorders. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

The protective and antioxidant effects of Hygrophila schulli seeds on oxidative damage of DNA and RBC cellular membrane

“…The protection of DNA indicated the presence of flavonoids and phenolic compounds like trycin and quercetin in H. shulli seeds which can prevent the production of ROS by complexing cations [ 44 ]. Extracts prepared from black raspberry [ 45 ] seed and various natural resources [ 46 ] could either stop or slow down the process of DNA damage. So these results indicate that H. schulli seeds is a potential source of antioxidants that prevent DNA damage.…”

Genotoxic Hazard and Oxidative Stress Induced by Wastewater Irrigated Soil With Special Reference to Pesticides and Heavy Metal Pollution

“…Breakage in plasmid DNA is also one of the critical parameter in determining the genotoxicity of wide range of chemicals and this test is very commonly used in environmental monitoring [89][90][91][92] . Incidence of DNA damage is profound indicator of potential risk of malignancy in human being 93 .…”

In-vitro Antioxidant Capacities and Genetic Classification of Indonesian Selected Pigmented Rice

“…Recently, pigmented rice has become more popular than non-pigmented rice due to its potential for healthy foods. Previous studies reported that pigmented rice has higher protein content than non-pigmented rice [3] . Moreover, its antioxidant activities and phytochemical contents are higher than nonpigmented rice [1] .…”