DNA damage in nurses handling antineoplastic agents

Fuchs, Juergen; Hengstler, Jan G.; Jung, Detlev; Hiltl, Gerd; Konietzko, J; Oesch, Franz

doi:10.1016/0165-1218(95)90086-1

Cited by 55 publications

(25 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous work, incorporation of antineoplastic agents by oncology personnel was detected despite standard safety precautions, such as the use of laminar airflow hoods and personal protective clothing [Pethran et al, 2003]. The importance of taking correct safety measures while occupationally handling antineoplastic drugs on the potential genotoxic risk has been revealed in several studies that analyzed individuals with different degrees of protection: the more protective measures were taken, the less genotoxic damage was observed [Oestreicher et al, 1990;Fuchs et al, 1995;Brumen and Horvat, 1996;Kevekordes et al, 1998]. Thus, our data suggest that safety measures adopted by the oncology nurses analyzed are not enough to prevent health hazards related to antineoplastic drug management.…”

Section: Discussionmentioning

confidence: 91%

Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes

Laffón¹,

Teixeira²,

Silva³

et al. 2005

Am. J. Ind. Med.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 91%

Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes

Laffón¹,

Teixeira²,

Silva³

et al. 2005

Am. J. Ind. Med.

View full text Add to dashboard Cite

show abstract

“…Some papers described the biological effects of antineoplastic drugs in nurses. Detection of chromosomal aberrations, sister chromatid exchanges, micronuclei, or DNA damage in peripheral lymphocytes were observed [33][34][35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Micronucleus formation induced by the combination of low doses of X-rays and antineoplastic drugs in bone marrow of male mice

Dobrzyńska¹

2000

Teratog. Carcinog. Mutagen.

View full text Add to dashboard Cite

People are widely exposed during their lifetime to many biological, chemical, and physical agents in the environment and at work. In this paper the effects of combined exposures of nonmutagenic doses of X-rays and anticancer agents (cyclophosphamide, mitomycin C, and vinblastine) have been investigated on the induction of micronuclei in the bone marrow of laboratory mice. The combination of X-rays and anticancer drugs enhanced the frequency of micronuclei in some cases. The strongest effects were found after the combination of X-rays and cyclophosphamide at 24 h and 72 h. The combined treatment of X-rays and mitomycin C enhanced the mutagenic effect at 72 h. The combination of X-rays + vinblastine slightly potentiated the mutagenic effect at 24 h and 48 h.

show abstract

“…Some studies have evidenced a reduced risk when effective protective measures were adopted 10,11) , so in the last few years the interest of occupational medicine in preventing workers' health risks related to antiblastic drugs exposure has been increasing and worldwide attempts have been made to prevent exposure [20][21][22][23] . In particular, recent attention has also focused on nursing staff handling antiblastic drugs that have to be administered to patients, and many European Directives (and related National Legislative Decrees and Guidelines) have been issued, aiming to protect nursing personnel potentially exposed to high amounts of various antiblastic drugs on a daily basis [24][25][26][27] .…”

Section: Journal Of Occupational Healthmentioning

confidence: 99%

“…At the end of 1970s Falck et al first evidenced the occurrence of primary tumours for nurses working without protective measures 8) . Subsequently, the possible long-term risk for personnel handling antineoplastic drugs has been investigated and mutagenic (micronuclei and chromosomic aberrations) [9][10][11] and carcinogenic effects (leukemia and non-Hodgking…”

mentioning

confidence: 99%

Evaluation of Occupational Exposure to Antiblastic Drugs in an Italian Hospital Oncological Department

Castiglia

Miraglia

Pieri

et al. 2008

Journal of Occupational Health

View full text Add to dashboard Cite

Evaluation of Occupational Exposure to Antiblastic Drugs in an Italian Hospital OncologicalDepartment: Loredana CASTIGLIA, et al. Department of Public Medicine and Social Health, University of Naples "Federico II", Italy-The determination of the current antiblastic drug contamination levels in an Italian hospital oncology ward was carried out. Statistical evaluation of data aiming to identify potential exposure causes was performed. Cyclophosphamide (CP), ifosfamide (IF) and 5-fluorouracil (5-FU) were determined by wipe tests, extracted with diatomaceous earths and quantified by GC/MSMS or HPLC/UV. Data were analysed with respect to the potential contamination levels of sampled surfaces, and various amounts of handled analyte. χ 2 tests and Spearman correlation coefficients were calculated. Median concentration levels of 0.086, 0.071, 2.363 µg/dm 2 were obtained, (CP, IF, 5-FU, respectively). 3.8 and 13.5% of investigated surfaces showed CP and IF concentrations higher than 1 µg/dm 2 (up to 26.96 µg/ dm 2 ) and 13.4% of samples contained 5-FU concentrations in the range 20-208.9 µg/dm 2 . Analytes' concentration levels were dependent on sampling sites, with significant correlations showing a progressive contamination decrement going from workbenches, floor, hood planes and other surfaces. A diffuse contamination (traces of all the three analytes) was found on all investigated surfaces, even when analytes had not been used during the sampling days. A significant correlation (ρs=0.303, p=0.001) between the measured analyte concentration and the analyte handled amount was found only in the case of IF. The risk management strategy should be improved, as suggested by the measured and widespread levels of contamination. Since contamination also depends on other factors attributable to working modalities and cleaning procedures, the obtained results suggest that performance of specific training courses as well as scheduling environmental monitoring plans to achieve an actual decrement of the observed contamination levels should be implemented. (J Occup Health 2008; 50: 48-56)

show abstract

DNA damage in nurses handling antineoplastic agents

Cited by 55 publications

References 12 publications

Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes

Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes

Micronucleus formation induced by the combination of low doses of X-rays and antineoplastic drugs in bone marrow of male mice

Evaluation of Occupational Exposure to Antiblastic Drugs in an Italian Hospital Oncological Department

Contact Info

Product

Resources

About