DNA damage in liver cells of the tilapia fish Oreochromis mossambicus larva induced by the insecticide cyantraniliprole at sublethal doses during chronic exposure

Xu, Chengbin; Fan, Yongmei; Zhang, Xiaokai; Kong, Weihao; Miao, Weiguo; Li, Qing X.

doi:10.1016/j.chemosphere.2019.124586

Cited by 9 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 The 96 h LC 50 of cyantraniliprole for juvenile tilapia (Oreochromis mossambicus) was found to be 38.0 mg/L in a previous study, indicating low cyantraniliprole acute toxicity toward tilapia; however, after 28 days of chronic exposure, the tilapia growth rate gradually decreased with increasing cyantraniliprole concentration. 6 Therefore, the acute toxicity of cyantraniliprole for aquatic organisms is relatively low, but chronic exposure to cyantraniliprole at low concentrations can lead to toxic effects. Previous studies have reported that P. clarkii exposed to different concentrations of pesticides exhibits varying degrees of behavioral abnormalities.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 However, the toxic effects of cyantraniliprole on aquatic species have not been extensively explored, and only a few studies have reported its toxic effects on aquatic organisms such as tilapia (Oreochromis mossambicus) and daphnia (Daphnia magna). 5,6 The 96 h LC 50 value of cyantraniliprole for the aquatic insect Chironomus dilutus is 4.7 μg/L, and the value of imidacloprid treatment was 7.0 μg/L, indicating that ryanodine receptor agonists may pose a higher risk to aquatic organisms than their neonicotinoid predecessors. 7 Therefore, elucidation of the ecotoxicological effects of cyantraniliprole on crayfish is crucial.…”

Section: Introductionmentioning

confidence: 99%

“…Cyantraniliprole (Cyazypyr) is a diamide (group 28) insecticide (IRAC, 2012) with a half-life value about 5 days, which is a ryanodine receptor modulator that controls various crop pests, especially Chilo suppressalis, Cnaphalocrocis medinalis, and rice planthoppers in rice fields and RCIS . Most studies on cyantraniliprole have focused on its lethal effects on target pests such as Lepidoptera (e.g., Pyralidae and Noctuidae) and Hemiptera (e.g., Delphacidae and Aleyrodidae), resistance in target organisms, insecticidal efficacy in the field, and its removal from fruits, vegetables, and crops. , However, the toxic effects of cyantraniliprole on aquatic species have not been extensively explored, and only a few studies have reported its toxic effects on aquatic organisms such as tilapia (Oreochromis mossambicus) and daphnia (Daphnia magna). , The 96 h LC 50 value of cyantraniliprole for the aquatic insect Chironomus dilutus is 4.7 μg/L, and the value of imidacloprid treatment was 7.0 μg/L, indicating that ryanodine receptor agonists may pose a higher risk to aquatic organisms than their neonicotinoid predecessors . Therefore, elucidation of the ecotoxicological effects of cyantraniliprole on crayfish is crucial.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ecological Toxicity of Cyantraniliprole against Procambarus clarkii: Histopathology, Oxidative Stress, and Intestinal Microbiota

Liang,

Xu,

Chen

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Cyantraniliprole is a novel insecticide recently introduced for rice pest control that may cause potential threats to the red swamp crayfish (Procambarus clarkii) in rice−crayfish coculture systems. In this study, we investigated the acute toxicity of cyantraniliprole against P. clarkii with a LC 50 value of 149.77 mg/L (96 h), first. Some abnormal behaviors of P. clarkii treated with 125 mg/L cyantraniliprole, including incunabular hyperexcitability, imbalance, inactivity, and increased excretion were observed. Moreover, it was observed that exposure to 5 mg/L cyantraniliprole for 14 days resulted in histopathological alterations in abdominal muscle, gills, hepatopancreas, and intestines. Furthermore, exposure to 0.05 and 5 mg/L cyantraniliprole induced increased activities of several oxidative stress-related enzymes, which was verified by the upregulation of related genes. Additionally, dysregulation of the intestinal microbiota was determined via 16S rRNA sequencing. These results will provide the basis for the utilization of cyantraniliprole in the fields of rice−crayfish integrated system.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ecological Toxicity of Cyantraniliprole against Procambarus clarkii: Histopathology, Oxidative Stress, and Intestinal Microbiota

Liang,

Xu,

Chen

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…The gene expression profiles of nine genes (namely, cox2, nad7, atpb, atpal, atpa; katna1, clpp, atp2b1, and gtpbpal) were detected in the sampled blood tissues. However, genes associated with anti-oxidative system (sod, cat, gpx), apoptosis (chk2) and DNA damage (rpa3, Xu et al, 2020) have also been detected. β-actin was chosen as the reference gene as its expression remained constant among the experimental groups ( Supplementary Table S4), and the cDNAs for the gene expression analysis were normalized with β-actin.…”

Section: Qrt-pcr For Gene Expression Verificationmentioning

confidence: 99%

Transcriptome Analysis of Juvenile Tilapia (Oreochromis niloticus) Blood, Fed With Different Concentrations of Resveratrol

Zheng

et al. 2020

Front. Physiol.

View full text Add to dashboard Cite

Oreochromis niloticus (genetically improved farmed tilapia, GIFT) often bites the root of Polygonum cuspidatum when it is used as a floating bed, and resveratrol (RES) is mainly accumulated in the root of P. cuspidatum. Blood acts as a pipeline for the fish immune system. Generating blood transcriptomic resources is crucial for understanding molecular mechanisms underlying blood immune responses. In this study, we determined the effects of RES administration on blood transcriptomic response in GIFT. With increasing RES concentration, 133 (0.025 vs. 0.05 g/kg RES), 155 (0.025 vs. 0.1 g/kg RES), and 123 (0.05 vs. 0.1 g/kg RES) genes were detected as significant differentially expressed genes (DEGs). Three and ninety-five shared significant DEGs were found to be enriched among the three (except 0.1 g/kg RES) and four groups (0, 0.025, 0.05, and 0.1 g/kg RES), respectively. To determine the relationship between mitochondrial regulation and RES supplementation, the results of RNA-Seq were analyzed and nine mitochondria-related genes (ATP synthase or mitochondrial-function-related genes) were verified. The results revealed the same expression pattern: cytochrome c isoform X2 (cox2), katanin p60 ATPase-containing subunit A1 isoform X1 (katna1), plasma membrane calcium-transporting ATPase 1-like (atp2b1) and GTP-binding protein A-like (gtpbpal) showed the highest expression in the 0.1 g/kg RES group, while NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 mitochondrial (nad7), ATP synthase subunit beta, mitochondrial (atpb), ATP synthase subunit alpha, mitochondrial-like (atpal), ATP synthase subunit alpha, mitochondrial (atpa) and ATP-dependent Clp protease proteolytic subunit, mitochondrial (clpp) revealed a dose-dependent expression following RES supplementation. Blood Ca2+-ATPase activity, and malondialdehyde, glutathione, and ATP content were significantly increased in the 0.05 (except Ca2+-ATPase activity), 0.1 g/kg RES group when compared with the controls. Eighty-nine shared DGEs were mainly enriched in antigen processing and presentation, cell adhesion molecules and phagosome pathways, based on the comparison between previous reported hepatic and the present blood transcriptome. Our study demonstrated that RES supplementation might improve the resistance to metabolism dysfunction via mitochondrial energy synthesis and/or the respiratory chain (e.g., ATPase).

show abstract

“…To further extend the market life of cyantraniliprole and broaden its use, it is necessary to explore the uptake and distribution of cyantraniliprole in wheat. 9 Besides, cyantraniliprole was found to be toxic to some nontarget species by inducing DNA damage in the liver cells of tilapia 10 or causing oxidative stress effects in earthworms. 4 Therefore, there is a practical need to study the uptake and accumulation characteristics of cyantraniliprole in the wheat planting system to prevent possible food safety risks.…”

Section: ■ Introductionmentioning

confidence: 99%

Uptake, Translocation, and Distribution of Cyantraniliprole in a Wheat Planting System

Cao

Zhang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Cyantraniliprole uptake, translocation, and distribution in wheat plants grown in hydroponics and soil conditions were investigated. The hydroponics experiment indicated that cyantraniliprole was prone to be absorbed by wheat roots mainly through the apoplastic pathway and predominately distributed in the cell-soluble fraction (81.4–83.6%) and ultimately transferred upward to leaves (TFleave/stem = 4.84 > TFstem/root = 0.67). In wheat-soil systems, the uptake of cyantraniliprole was similar to that in hydroponics. The accumulation of cyantraniliprole in wheat tissues was mainly affected by the content of soil organic matter and clay, resulting in the increased adsorption of cyantraniliprole onto soils (R 2 > 0.991, P < 0.01), and was positively related to the concentration of cyantraniliprole in soil pore water (R 2 > 0.991, P < 0.001). Besides, the absorption of cyantraniliprole by wheat was predicted well by the partition-limited model. These results increased our understanding of the absorption and accumulation of cyantraniliprole in wheat and were also helpful for guiding the practical application and risk evaluation of cyantraniliprole.

show abstract

DNA damage in liver cells of the tilapia fish Oreochromis mossambicus larva induced by the insecticide cyantraniliprole at sublethal doses during chronic exposure

Cited by 9 publications

References 26 publications

Ecological Toxicity of Cyantraniliprole against Procambarus clarkii: Histopathology, Oxidative Stress, and Intestinal Microbiota

Ecological Toxicity of Cyantraniliprole against Procambarus clarkii: Histopathology, Oxidative Stress, and Intestinal Microbiota

Transcriptome Analysis of Juvenile Tilapia (Oreochromis niloticus) Blood, Fed With Different Concentrations of Resveratrol

Uptake, Translocation, and Distribution of Cyantraniliprole in a Wheat Planting System

Contact Info

Product

Resources

About