DNA damage: beta zero versus beta plus thalassemia

Abstract

In the present study, iron toxicity, as indicated by DNA damage, has been seen to vary in the patients. Thus, monitoring of the dose of iron chelators, according to the type of mutation in the beta globin gene, may help improve the compliance of beta thalassemics to chelation therapy and prevent side-effects in patients with beta plus mutations.

Alpha hemoglobin stabilizing protein: Its causal relationship with the severity of beta thalassemia

“…Varying degrees of DNA damage in developing RBCs of these subjects have already been demonstrated [16]. The present study shows a weak negative correlation, with an r = −0.3109, between DNA damage and the fold change in AHSP levels (Fig.…”

Research on the clinical factors of cardiac iron deposition in children with beta-thalassemia major

“…Differences in genotype can also exhibit varying degrees of cardiac iron deposition. Sagar et al found that iron toxicity-induced DNA damage was greater in β0 homozygotes than in β0 heterozygotes or β0β+ heterozygotes [ 16 ]. Pistoia et al conducted a cross-sectional study of MRI T2* values and cardiac iron deposition in different genomes of β-TM patients and found that β0 homozygotes and β0β+ heterozygous patients had higher levels of cardiac iron deposition than β+ homozygotes [ 17 ].…”

Intracellular iron overload leading to DNA damage of lymphocytes and immune dysfunction in thalassemia major patients

“…In splenectomized thalassemic individuals, the presence of NRBCs in peripheral blood is significantly high . Recently, Sagar et al studied DNA damage in NRBCs and showed its association with beta zero and beta plus mutations. We have shown in our study that not only NRBCs, but thalassemic lymphocytes too contain inherent DNA damage, which persists even after regular oral iron chelation therapy.…”