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Among a total of 29 blood group systems and over 600 different blood group antigens discovered so far, ABO and Rhesus are the most important blood group systems. The most significance rhesus antigen is Rh-D because of its immunogenicity. The sound knowledge of ABO and Rh-D antigens and its distribution in population is essential for the effective management of blood transfusion services, in population genetic studies, in resolving medico-legal issues and more importantly in compatibility test in blood transfusion practice. Study is aimed to provide data on ABO and Rh-D distribution in Gwalior region (Madhya Pradesh) and its comparison with related studies in India and abroad. Total 90,000 samples in 4 years from January 2004 to December 2007 were grouped for ABO, Rh-D and their subgroups at

Aim: This study was aimed to review and establish the practice of exchange transfusion (ET) with whole blood reconstituted (WBR) in hemolytic disease of newborn (HDN). Objectives: To observe fall in indirect serum bilirubin, correction of anemia and comparison with related studies. Background: Hemolytic disease of the Newborn is characterized by presence of IgG antibodies in maternal circulation, which causes hemolysis in the fetus by crossing the placenta and sensitizing red cells for destruction by macrophages in the fetal spleen with consequent hyperbilirubinemia. Exchange transfusion with or without phototherapy is the method of choice for treating the newborn with on going hemolysis Methods/Materials: Sample size consisted of 110 neonates in whom 119 exchange transfusions were carried out with WBR. WBR was prepared by suspending O Rhesus-D (RhD) positive/negative cells (compatible with neonate's/ mother's serum) in AB plasma. Double volume exchange transfusion(s) were carried out through umbilical vein by push-pull technique. Results: Out of 110 cases, 61 (55.5%) were of RhD HDN whereas ABO and other group HDN cases were 30 (27.3%) and 19 (17.3%) respectively. An average post-ET fall in indirect serum bilirubin by 54.6% and correction of anemia by 3.7 gm/dl were reported in the study. Conclusion: An average post-ET fall in indirect serum bilirubin and correction of anemia was found to be more significant when compared to other studies. Hence we recommend exchange transfusion in HDN with WBR to obtain reasonable fall in indirect serum bilirubin and high average rate of correction of anemia.

The concurrence of malaria and hemoglobinopathies, observed in malaria endemic regions, reflects the phenomenon of natural selection. Since the life cycle of the malaria parasite has an erythrocytic stage, abnormalities in the red blood cells (RBCs) hinder the parasite's survival in the human host. Hemoglobin (Hb) variants affect the life span of RBCs and thus lower the chance of infection by the parasite. While a change in just one of the Hb genes offers some protection against malaria, change in both alleles results in β-thalassemia major (β-TM). A striking geographical heterogeneity of β-thalassemia (β-thal) has been observed. Moving from Mexico in the west to China towards the east, the spectrum of mutations in the β-globin gene has been seen to vary. In the western end of the thalassemia belt, defects in the first intervening sequence (IVS-I) and exon 2 of the β-globin gene are more common, while on the eastern coast, IVS-II and exon 1 are also vulnerable to mutations. The worldwide increase in the incidence of β-TM mandates the need for efficient measures to reduce β-thal births, and the geographical heterogeneity of β-thal alleles reduces the burden of genetic testing of fetuses suspected of carrying a mutant allele. In the present review, the common mutations in the global thalassemia belt have been illustrated, and the possible factors that affect the mutagenicity of sites have been discussed. A biogeographic analysis that may provide insight into the non biological factors influencing different loci in the β-globin gene in different geographical regions is suggested.

Introduction: Transfusion Transmitted Infections (TTIs) are a major problem associated with blood transfusion. Accurate estimates of risk of TTIs are essential for monitoring the safety of blood supply and evaluating the efficacy of currently employed screening procedures. Aims: To determine the prevalence of transfusion transmitted infections among blood donors in greater Gwalior region and its surrounding areas i.e. central India and its comparison with other relevant studies.

Background: Menstruation is a normal physiological process to the females but sometimes it is considered as unclean phenomenon in the society. Hence this community based study was carried out with the objective to assess the difference in level of knowledge and practice regarding menstrual hygiene among school going adolescent girls of government and private school.Methods: A community-based cross-sectional study was conducted from July 2017 to April 2018 to find out the difference in prevailing knowledge and practices regarding menstrual hygiene between private and government school going adolescent girls of Jaipur city. Data were collected by the predesigned and pretested structured questionnaire.Results: 87.57% girls from private schools were aware of menstruation prior to attainment of menarche. The difference in knowledge regarding menstruation in students of private and government school was significant. More than three fourth of the participants (76.95%) were from private school use sanitary pad.Conclusions: Knowledge and practice regarding menstruation was better in private school girls as compared to those of government school. Significantly more number of girls in the private schools was using sanitary pads as compared to government school girls.

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