DNA damage and repair in the female germline: contributions to ART

Martin, Jacinta H.; Aitken, R. John; Bromfield, Elizabeth G.; Nixon, Brett

doi:10.1093/humupd/dmy040

Cited by 54 publications

(40 citation statements)

References 194 publications

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“…In the female germinal cells the oocytes characterized by a large cytoplasm have an antioxidant defense, which allows the oocytes to protect their genomic material as they transition through oogenesis [20,27]. In fact, a stringent surveillance is present in order to repair or eliminate oocytes with compromised genomic fidelity which could cause subfertility and infertility [20,28]. Heat stress during oogenesis compromises oocyte maturation, leading to alterations in follicular function, follicular growth, steroid secretion, and gene expressions [21,[29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Antioxidative Defense and Fertility Rate in the Assessment of Reprotoxicity Risk Posed by Global Warming

Parisi

Guerriero

2019

Antioxidants

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The objective of this review is to briefly summarize the recent progress in studies done on the assessment of reprotoxicity risk posed by global warming for the foundation of strategic tool in ecosystem-based adaptation. The selected animal data analysis that was used in this paper focuses on antioxidative markers and fertility rate estimated over the period 2000–2019. We followed a phylogenetic methodology in order to report data on a panel of selected organisms that show dangerous effects. The oxidative damage studies related to temperature fluctuation occurring in biosentinels of different invertebrate and vertebrate classes show a consistently maintained physiological defense. Furthermore, the results from homeothermic and poikilothermic species in our study highlight the influence of temperature rise on reprotoxicity.

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Section: Introductionmentioning

confidence: 99%

Antioxidative Defense and Fertility Rate in the Assessment of Reprotoxicity Risk Posed by Global Warming

Parisi

Guerriero

2019

Antioxidants

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“…B 286: 20192187 mutations is already evident in the offspring of young human parents, and this difference remains relatively stable with increased parental age [45]. Chromosome-based abnormalities such as aneuploidy are more commonly of maternal than paternal origin [67], due to problems associated with the resumption of meiosis in primary oocytes after a long period of arrest [67]. Aneuploidy increases sharply in humans with maternal age, thought to be due to the maintenance of the chiasmata and sister chromatid cohesion becoming less secure in older oocytes, with eventual failure of chromosomes to segregate [74].…”

Section: Causes Of Germline Deteriorationmentioning

confidence: 99%

“…Germline maintenance is likely to be very expensive, and the capacity to invest in this may decrease with age [77]. Interestingly, some repair of the genome is known to occur in the zygote after fertilization, and it appears that the oocyte is responsible for this repair to both maternally and paternally derived DNA [67].…”

Section: Causes Of Germline Deteriorationmentioning

confidence: 99%

The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness

2019

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The idea that there is an impenetrable barrier that separates the germline and soma has shaped much thinking in evolutionary biology and in many other disciplines. However, recent research has revealed that the so-called ‘Weismann Barrier’ is leaky, and that information is transferred from soma to germline. Moreover, the germline itself is now known to age, and to be influenced by an age-related deterioration of the soma that houses and protects it. This could reduce the likelihood of successful reproduction by old individuals, but also lead to long-term deleterious consequences for any offspring that they do produce (including a shortened lifespan). Here, we review the evidence from a diverse and multidisciplinary literature for senescence in the germline and its consequences; we also examine the underlying mechanisms responsible, emphasizing changes in mutation rate, telomere loss, and impaired mitochondrial function in gametes. We consider the effect on life-history evolution, particularly reproductive scheduling and mate choice. Throughout, we draw attention to unresolved issues, new questions to consider, and areas where more research is needed. We also highlight the need for a more comparative approach that would reveal the diversity of processes that organisms have evolved to slow or halt age-related germline deterioration.

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“…During IVC of the human ovarian cortex, more primordial follicles were activated, and more secondary follicles were isolated with PTEN inhibition. Unfortunately, the survival and development of isolated follicles were poor (26,36), which may be related to the effect of PTEN inhibition on the DNA repair mechanism in follicles (12). The study involving IVC of bovine ovarian cortex demonstrated that PTEN inhibition activated bovine non-growing follicles, but simultaneously increased DNA damage and reduced DNA repair response (27).…”

Section: Initial Stage: In Vitro Activation (Iva) Of Primordial Follimentioning

confidence: 99%

“…During in vivo follicle growth, oocytes acquire the competence to resume meiosis, complete fertilization, and support early embryonic development. Thorough comprehension to this complicated growth procedure is essential for researchers to construct an IVC system meeting all requirements, with consideration for maintaining DNA integrity and stability (11,12). In previous studies, a two-step culture system was designed for follicular development in mouse models, where the IVC oocytes were fertilized and healthy offspring were successfully obtained (13,14).…”

Section: Introductionmentioning

confidence: 99%

Human Follicle in vitro Culture Including Activation, Growth, and Maturation: A Review of Research Progress

2020

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Fertility preservation has received unprecedented attention nowadays. In addition to cryopreservation and re-implantation of embryos, oocytes, and ovarian tissue pieces, in vitro culture system for follicles/oocytes has been considered as an alternative strategy for fertility preservation. Since the metabolic dynamics and required nutrients are not entirely the same in different stages of follicular development, optimization of each culture step is needed. In this paper, literature regarding culture conditions in three steps were analyzed. Known additives in activation stage included 740Y-P, bpV(HOpic), follicle stimulating hormone (FSH), human serum albumin (HSA), ITS, growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and cyclic adenosine monophosphate (cAMP), with different degrees of activation promotion and potential detrimental effect on DNA integrity. For isolated follicles growth stage, actin A, FSH, basic fibroblast growth factor (bFGF), estradiol were proved to improve development or proliferation. As for maturation, addition of growth hormone, melatonin, C-type natriuretic peptide (CNP), GDF9, cilostamide, or forskolin helped to regulate maturation rate or improve oocyte quality. Based on previous sequential culture system for human follicles, optimization is needed to achieve higher maturation rate and better oocyte quality, pursuant to current review, which demonstrated the effects of various additives on different stages.

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DNA damage and repair in the female germline: contributions to ART

Cited by 54 publications

References 194 publications

Antioxidative Defense and Fertility Rate in the Assessment of Reprotoxicity Risk Posed by Global Warming

Antioxidative Defense and Fertility Rate in the Assessment of Reprotoxicity Risk Posed by Global Warming

The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness

Human Follicle in vitro Culture Including Activation, Growth, and Maturation: A Review of Research Progress

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