DNA damage and oxidative stress in patients with mild preeclampsia and offspring

Hilali, Neşe Gül; Koçyiğit, Abdürrahim; Demir, Mehmet Emin; Camuzcuoğlu, Aysun; Incebiyik, Adnan; Camuzcuoğlu, Hakan; Vural, Mehmet; Taşkın, Abdullah

doi:10.1016/j.ejogrb.2013.07.031

Cited by 29 publications

(16 citation statements)

References 25 publications

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“…Although increased oxidative stress is already accepted to be implicated in preeclampsia, either as a pathogenetic mechanism or as a consequence, the controversy about the possible roles of antioxidant status and enzyme levels remains [28]. A number of studies reported decreased TAS levels as a reduction in antioxidant defense mechanisms in preeclampsia [22,27,29]. These studies are contradictory to our results since we found significantly increased levels of TAS in severely preeclamptic patients.…”

Section: Discussioncontrasting

confidence: 99%

“…Oxidative stress has been already suggested to play an important role in the pathogenesis of placenta-related diseases [26]. Various studies showed increased oxidant status in preeclamptic pregnancies and suggested that oxidative stress is a major contributor in preeclampsia-related endothelial dysfunction [10,22,27]. Our findings are consistent with the results of previous studies as we found elevated levels of maternal serum TOS to be associated with severe preeclampsia.…”

Section: Discussionsupporting

confidence: 92%

“…However, previous studies reported conflicting results of maternal serum PON and arylesterase levels in preeclampsia [15,21]. Furthermore, the reported total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were also controversial in different studies [10,22]. Considering the results of the above-mentioned studies, we hypothesized that since preeclampsia and atherosclerotic diseases share a common pathophysiological mechanism, namely endothelial dysfunction, it may cause alterations in the perfusion of the utero-placental-fetal unit and lead to adverse perinatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Öztaş

Özler²,

Tokmak³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to determine maternal serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON) and arylesterase levels in severe preeclamptic pregnants and also to investigate whether these parameters are implicated in the occurence of perinatal morbidity or not. Material and methods:A case-control study was carried out including 60 pregnant women (30 with severe preeclampsia and 30 healthy controls). The optimal cut off points of oxidative stress markers for the diagnosis of severe preeclampsia and for the prediction of adverse perinatal outcomes were evaluated by receiver operating characteristic (ROC) analyses. Multivariate logistic regression analysis was used to determine if a relationship between adverse perinatal outcomes and serum oxidative stress markers was present or not.Results: TAS (OR = 37.486, 95% CI 3.535-397.519, p = 0.003), TOS (OR = 15.588, 95% CI 2.135-113.818, p = 0.007) and arylesterase (OR = 31.356, 95% CI 2.284-430.548, p = 0.01) were found to be diagnostic for preeclampsia. Statistically significant positive correlation of adverse perinatal outcomes with serum TAS, PON and arylesterase levels were determined. Besides, a significant negative correlation was found between serum TAS levels and gestational week (r = -0.342, p = 0.007) and also between serum PON levels and birthweight (r = -0.262, p = 0.043). Conclusions:Increased maternal serum TAS, TOS and arylesterase levels are significantly associated with the presence of severe preeclampsia. Furthermore, elevated maternal serum TAS, PON and arylesterase levels are significantly and positively correlated with adverse perinatal outcomes. We suggest that in preeclampsia increased oxidative status may cause adverse perinatal outcomes and antioxidants may be increased in order to protect the fetus against oxidative damage.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Öztaş

Özler²,

Tokmak³

et al. 2016

Ginekol Pol

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“…Prenatal growth restraint has been associated with increased oxidative stress in pregnancies complicated by preeclampsia or diabetes [14,15,16]. However, data on the link between prenatal growth restriction and placental mtDNA copy number in uncomplicated, term pregnancies resulting in the delivery of small-for-gestational-age (SGA) infants are scarce and controversial, mainly because the studied cohorts were heterogeneous and the assessments were performed at different timings (during or after delivery) and in different conditions (either in cord blood samples or in placental tissue).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA in Placenta: Associations with Fetal Growth and Superoxide Dismutase Activity

et al. 2014

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Background: Prenatal growth restraint is associated with increased oxidative stress - as judged by mitochondrial dysfunction - in pregnancies complicated by preeclampsia or diabetes, but it is uncertain whether this is also the case in uncomplicated pregnancies. We assessed the link between fetal growth restraint and placental mitochondrial dysfunction, as reflected by changes in mitochondrial DNA (mtDNA) content and superoxide dismutase (SOD) activity. Methods: After uncomplicated pregnancies, placentas (n = 48) were collected at term delivery of singleton infants who were appropriate for gestational age (AGA) or small for gestational age (SGA) (n = 24 in each subgroup). Placental mtDNA content was assessed by real-time PCR, placental SOD activity by colorimetry, and citrate synthase activity - to determine mitochondrial mass - by the spectrophotometric method. Results: Placentas of SGA infants had a lower mtDNA content (p = 0.015) and a higher SOD activity (p = 0.001) than those of AGA controls. These differences were maintained after normalization of the mtDNA content by citrate synthase activity. In placentas of SGA infants, there was a negative association between mtDNA content and SOD activity (r = -0.58, p = 0.008). Conclusions: Fetal growth restraint is accompanied by adaptive changes in the mitochondrial function of the placenta, also in uncomplicated pregnancies.

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“…Öztürk et al observed significantly lower levels of TAS in the placenta of pregnant patients having preeclampsia when they were compared with healthy controls, and showed its significant relation with the maternal serum TAS levels (24). Moreover, Hilali et al demonstrated significantly lower levels of TAS and increased levels of TOS and OSI in the maternal serum and cord samples of patients having mild preeclampsia (25).…”

Section: Discussionmentioning

confidence: 99%

Decreased oxidative stress may contribute to the disease process in placenta accreta

Öztaş¹,

Özler²,

Ergin³

et al. 2017

Turk J Med Sci

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Background/aim: The main aim of this study was to investigate serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase levels in pregnant women with placenta accreta and to compare those with age-matched healthy pregnant women. Materials and methods:A total of 27 pregnant women who had clinically and pathologically proven placenta accreta and 30 age-and BMI-matched healthy pregnant women were enrolled in this case control study. Maternal serum TOS, TAS, OSI, and arylesterase levels were evaluated using logistic regression analysis to determine if there was an association with abnormal placental invasion or not.Results: Decreased OSI (OR= 0.999, 95%CI: 0.998-1.000, P = 0.035) and increased arylesterase levels (OR= 0.981, 95%CI: 0.970-0.993, P = 0.001) were significantly associated with the presence of placenta accreta. Maternal serum TOS, TAS, OSI, and arylesterase levels were not predictive for adverse perinatal outcomes (P > 0.05). Conclusions:Decreased OSI and increased arylesterase levels are significantly associated with placenta accreta and may contribute to the abnormal invasion process.

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DNA damage and oxidative stress in patients with mild preeclampsia and offspring

Cited by 29 publications

References 25 publications

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Mitochondrial DNA in Placenta: Associations with Fetal Growth and Superoxide Dismutase Activity

Decreased oxidative stress may contribute to the disease process in placenta accreta

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