DNA/BSA binding, DNA cleavage and electrochemical properties of new multidentate copper(ii) complexes

Abstract

A new series of multidentate copper(ii) complexes [Cu(L1−5)](ClO4) (1–5) were synthesized and characterized for their DNA/BSA binding, DNA cleavage, cytotoxic properties and antimicrobial activities.

Biological evaluation of selected 3,4‐dihydro‐2(1H)‐quinoxalinones and 3,4‐dihydro‐1,4‐benzoxazin‐2‐ones: Molecular docking study

“…In Table are presented quenching parameters for 5 , 9–11 [(6.3 ± 0.2) × 10 3 , (5.6 ± 0.2) × 10 3 , (3.1 ± 0.2) × 10 3 , and (5.1 ± 0.1) × 10 3 M −1 , respectively] and these values indicate that the tested compounds have affinity to substitute EB from the EB‐DNA complex and bind strongly with DNA through intercalation. Also, measured K sv clearly indicated that these values are in order with the constants obtained for potential metal‐drugs …”

Synthesis, Characterization, Photophysical and Electrochemical Studies of Ruthenium(II) Complexes with 4′‐Substituted Terpyridine Ligands and Their Biological Applications

“…The intercalative mode involves a strong stacking interaction between the aromatic chromophore moiety of the ruthenium(II) complexes with base pairs of DNA. [33,34,35] Generally, the electrostatic interaction of complexes with DNA results in lower hypochromism and no bathochromic shift is observed. [36] The absorption titration of complexes with DNA shows hypochromism and a small red shift indicating classical or partial intercalation with DNA.…”

“…Ru(II) complexes can bind to DNA through intercalation resulting in change in absorption as well as red shift in wavelength and decrease in hypochromism. The intercalative mode involves a strong stacking interaction between the aromatic chromophore moiety of the ruthenium(II) complexes with base pairs of DNA ,,. Generally, the electrostatic interaction of complexes with DNA results in lower hypochromism and no bathochromic shift is observed .…”

Ferrocene‐substituted bis(ethynyl)anthracene compounds as anticancer agents

“…The binding constants ( K b ) were determined using the equation where [DNA] is the concentration of DNA and ε a , ε f and ε b correspond to the apparent extinction coefficient, the extinction coefficient of unbound compound and the extinction coefficient of fully bounded compound, respectively. A plot of [DNA]/( ε a − ε f ) versus [DNA] gives the binding constant K b as the ratio of the slope to the intercept …”

“…A plot of [DNA]/(ε a − ε f ) versus [DNA] gives the binding constant K b as the ratio of the slope to the intercept. [34,45] DNA binding with 1-3 was also measured by a fluorescence spectral technique; EB displacement assay from EB-bound CT-DNA in Tris-HCl buffer at biological pH (7.4) was done. EB was used as it is non-emissive in Tris-HCl buffer solution (pH = 7.4) because of fluorescence quenching of independent EB by the solvent.…”