DNA Antibody In The Serum Of Patients In Shock

Nick, William V.; Dodd, Matthew C.

doi:10.1097/00000658-196709000-00017

Cited by 10 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, circulating DNA has assumed clinical importance because of its association with several human disorders and, in particular, with the immune complex nephritis accompanying SLE, in which, in combination with anti‐DNA antibody, it appears to play an etiologic role 2. In addition, reports have suggested that anti‐DNA antibody might be found not only in SLE, but also in the serum of patients with severe shock, thus becoming a prognostic marker 12,20. The possibility that DNA antibodies can prevent the formation of messenger RNA, or otherwise block the mechanism of protein synthesis during shock, points to the therapeutic use of nucleotides for inhibiting these potential antibody effects 20…”

Section: Resultsmentioning

confidence: 99%

“…In addition, reports have suggested that anti‐DNA antibody might be found not only in SLE, but also in the serum of patients with severe shock, thus becoming a prognostic marker 12,20. The possibility that DNA antibodies can prevent the formation of messenger RNA, or otherwise block the mechanism of protein synthesis during shock, points to the therapeutic use of nucleotides for inhibiting these potential antibody effects 20…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Detection of DNA in the Plasma of Septic Patients

Martins

Kawamura

Carvalho

2000

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Small amounts of plasma-free DNA have been observed both in healthy individuals and in patients with various diseases such as systemic lupus erythematosus, rheumatoid arthritis, viral hepatitis, and cancer. This communication demonstrates that septic patients also release DNA in plasma. After DNA extraction from plasma, exon 1 of the K-ras gene was amplified by PCR and products were analyzed by dot-blot hybridization. Plasmas from polytraumatic patients and control healthy individuals were used for comparisons with septic patients. Our results show that septic patients present DNA in their plasma. As far as we know, this is the first evidence of circulating DNA in septic patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%