Dmso as an Adjutant to Physical Therapy in the Chronic Frozen Shoulder

Parsons, James L.; Shepard, W. L.; Fosdick, William M.

doi:10.1111/j.1749-6632.1967.tb34926.x

Cited by 11 publications

(4 citation statements)

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“…Gastrointestinal adverse reactions were reported in 61 studies. Of these, 10 studies were randomized controlled trials 16, 30, 33, 55, 57, 59, 67, 79, 93, 95 , 49 were cohort studies 2, 4, 7, 9, 18, 19, 23, 25– 27, 29, 35, 38– 43, 45, 46, 48, 50– 54, 58, 60, 66, 68, 69, 71, 73, 83, 85– 88, 90, 94, 97, 98, 101, 104, 105, 112, 113, 115, 118 , and 2 were case series 84, 109 . Most studies reported the number of patients experiencing an adverse reaction ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Halitosis was reported in 29 studies 4, 9, 16, 19, 29, 30, 35, 42, 43, 45, 50, 52, 55, 57, 58, 66– 68, 79, 83, 85, 88, 94, 95, 97, 98, 109, 112, 113 . In five studies, patients discontinued treatment due to halitosis 9, 45, 83, 94 .…”

Section: Resultsmentioning

confidence: 99%

“…Skin reactions or allergic reactions were reported in 58 studies. DMSO was applied transdermally in 43 studies 2, 4, 6, 17, 19– 22, 24, 28– 32, 37, 44, 45, 52, 55, 57, 63, 64, 66, 67, 69, 72, 75, 76, 78, 79, 82, 83, 88, 89, 93, 95, 96, 106, 108, 109, 111– 113 , intravenously in 14 studies 25, 40, 41, 51, 59, 73, 74, 77, 85, 86, 92, 98, 101, 110 and intraarticular in one 103 ( Table 5).…”

Section: Resultsmentioning

confidence: 99%

“…Overall, there was a high risk of bias when assessing the description of adverse reactions. Some studies were not assessed for bias due to being case-reports, preliminary trials, or because they included more than one study design 17, 19, 28, 62, 84, 91, 99, 109, 111, 113 .…”

Section: Resultsmentioning

confidence: 99%

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Adverse reactions of dimethyl sulfoxide in humans: a systematic review

et al. 2019

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Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs. Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made. Our aim was to conduct a systematic review describing the adverse reactions observed in humans in relation to the use of DMSO. Methods: This systematic review was reported according to the PRISMA-harms (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. The primary outcome was any adverse reactions occurring in humans in relation to the use of DMSO. We included all original studies that reported adverse events due to the administration of DMSO, and that had a population of five or more. Results: We included a total of 109 studies. Gastrointestinal and skin reactions were the commonest reported adverse reactions to DMSO. Most reactions were transient without need for intervention. A relationship between the dose of DMSO given and the occurrence of adverse reactions was seen. Conclusions: DMSO may cause a variety of adverse reactions that are mostly transient and mild. The dose of DMSO plays an important role in the occurrence of adverse reactions. DMSO seems to be safe to use in small doses. Registration: PROSPERO CRD42018096117.

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