Dimethyl sulfoxide: A review of its use in the rheumatic disorders

Trice, James M.; Pinals, Robert S.

doi:10.1016/0049-0172(85)90009-5

Cited by 28 publications

(19 citation statements)

References 89 publications

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“…DMSO has been used clinically as an anti-inflammatory agent in arthritis and other disease states (41,42). The present studies suggest that inhibition of IL-8 production may, in part, have contributed to its beneficial effects.…”

Section: Resultsmentioning

confidence: 70%

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Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

DeForge¹,

Fantone²,

Kenney³

et al. 1992

J. Clin. Invest.

220

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The hydroxyl radical (OH') scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood. At a concentration of 1% (vol/ vol), DMSO blocked IL-8 release by 90% in the presence of 1 ,ug/ml LPS at a 24-h time point, but did not affect cell viability or reduce the production of tumor necrosis factor (TNF), interleukin 6, or interleukin-1fi ). DMSO was found to directly inhibit IL-8 expression at the level of transcription. Furthermore, this effect was not LPS-specific, in that IL-8 production was reduced by DMSO to a similar extent upon stimulation of blood with phytohemagglutinin, aggregated immune complexes, TNF, or IL-1ft.Other oxygen radical scavengers that have been shown to inhibit OH-dependent reactions (dimethyl thiourea, thiourea, mannitol, and ethanol) also inhibited IL-8 production. Conversely, addition of H202 caused a dose-dependent stimulation of IL-8 release. These results provide evidence that reactive oxygen metabolites play an important role in the regulation of IL-8 production and suggest that reduction of IL-8 release may contribute to the beneficial effects ofantioxidants in experimental models of inflammation and ischemia/reperfusion injury.

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Section: Resultsmentioning

confidence: 70%

“…DMSO was chosen because it has low toxicity, it has been found to have beneficial effects in a wide range ofdisease models, and it possesses chemical properties which allow it to readily penetrate cell membranes (41,42 The effect of 1% DMSO on the time course of IL-8 production was also evaluated (Fig. 1 B).…”

Section: Resultsmentioning

confidence: 99%

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

DeForge¹,

Fantone²,

Kenney³

et al. 1992

J. Clin. Invest.

220

View full text Add to dashboard Cite

show abstract

“…• OH) scavenger, has been found to have beneficial effects in a variety of disease models and can easily penetrate through cell membranes (22). Measurement of IL-8-mRNA and protein in the supernatants demonstrated that increasing DMSO concentrations (0.2-1% (v/v)) resulted in a linear dose-dependent suppression of hyperosmolarity-induced IL-8 secretion…”

Section: Antioxidants Block the Hyperosmolarity-induced Secretion Andmentioning

confidence: 99%

Reactive Oxygen Intermediates Are Involved in IL-8 Production Induced by Hyperosmotic Stress in Human Bronchial Epithelial Cells

Loitsch

Mallinckrodt

Kippenberger

et al. 2000

Biochemical and Biophysical Research Communications

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“…Silica is considered one of the most important environmental substances, in the fashion of vinyl chloride and other chemicals (including trichloroethene and epoxy resins), that give rise to autoimmune diseases in exposed hosts (Trice and Pinals, 1985;Goldman, 1996;D'Cruz, 2000;Hess, 2002;Cooper et al, 2009).…”

Section: Silica Particles and Dysregulation Of Immune Response Leadinmentioning

confidence: 99%

Dysregulation of the immune system caused by silica and asbestos

Maeda

Nishimura

Kumagai

et al. 2010

Journal of Immunotoxicology

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Dimethyl sulfoxide: A review of its use in the rheumatic disorders

Cited by 28 publications

References 89 publications

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

Reactive Oxygen Intermediates Are Involved in IL-8 Production Induced by Hyperosmotic Stress in Human Bronchial Epithelial Cells

Dysregulation of the immune system caused by silica and asbestos

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