Dysregulation of the immune system caused by silica and asbestos

Maeda, Megumi; Nishimura, Yasumasa; Kumagai, Naoya; Hayashi, Hiroaki; Hatayama, Tamayo; Katoh, Masakazu; Miyahara, Naomi; Yamamoto, Shoko; Hirastuka, Junichi; Otsuki, Takemi

doi:10.3109/1547691x.2010.512579

Cited by 84 publications

(85 citation statements)

References 92 publications

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“…In a second step of our investigation, we verified whether the prevalence of SV40 antibodies determined in serum samples from MPM patients differed from that of workers who had been exposed to asbestos, which is a natural oncogenic mineral with immunosuppressive activity (34,35). Our study indicated that the prevalence of SV40 VP antibodies detected in workers who had been exposed to asbestos (n = 90) is 9% ( Fig.…”

Section: Resultsmentioning

confidence: 81%

“…2 and Table 1). Interestingly, the reduced prevalence of SV40-positive sera in workers previously exposed to asbestos is very likely due to the immune-suppressive activity of asbestos (34,35). This prevalence was also analyzed in comparison with that of the control group represented by healthy blood donors (n = 174) with the same median age (54.5 y).…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, SV40-positive MPM sera had a higher prevalence (26%) than that of workers exposed to asbestos fibers (9%), an immunosuppressive mineral (34,35), suggesting that asbestos may depress the immune system of these workers. A lower prevalence of SV40-positive sera was also detected in pregnant women (13%).…”

Section: Discussionmentioning

confidence: 99%

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High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

Mazzoni¹,

Corallini

Cristaudo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Human malignant pleural mesothelioma (MPM) is considered a rare tumor, but recent estimations indicate that one-quarter million people will die of this neoplasm in Europe in the next three decades. The mineral asbestos is considered the main causative agent of this neoplasm. MPM is largely unresponsive to conventional chemotherapy/radiotherapy. In addition to asbestos exposure, genetic predisposition to asbestos carcinogenesis and to simian virus (SV) 40 infection has also been suggested. SV40 is a DNA tumor virus found in some studies to be associated at high prevalence with MPM. SV40 sequences have also been detected, although at a lower prevalence than in MPM, in blood specimens from healthy donors. However, some studies have failed to reveal SV40 footprints in MPM and its association with this neoplasm. These conflicting results indicate the need for further investigations with new approaches. We report on the presence of antibodies in serum samples from patients affected by MPM that specifically react with two different SV40 mimotopes. The two SV40 peptides used in indirect ELISAs correspond to viral capsid proteins. ELISA with the two SV40 mimotopes gave overlapping results. Our data indicate that in serum samples from MPM-affected patients (n = 97), the prevalence of antibodies against SV40 viral capsid protein antigens is significantly higher (26%, P = 0.043) than in the control group (15%) represented by healthy subjects (n = 168) with the same median age (66 y) and sex. Our results suggest that SV40 is associated with a subset of MPM and circulates in humans.antibody | neoplasia

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Section: Resultsmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

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High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

Mazzoni¹,

Corallini

Cristaudo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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“…In addition to these studies, we have attempted to construct health-promoting living conditions. Thus, in this review we summarize our investigations regarding the (1) immunological effects of asbestos fibers, (2) immunological effects of silica particles, and (3) construction of a health-promoting living environment.…”

Section: Introductionmentioning

confidence: 99%

Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

Otsuki

Matsuzaki

Lee

et al. 2015

Environ Health Prev Med

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Among the various scientific fields covered in the area of hygiene such as environmental medicine, epidemiology, public health and preventive medicine, we are investigating the immunological effects of fibrous and particulate substances in the environment and work surroundings, such as asbestos fibers and silica particles. In addition to these studies, we have attempted to construct health-promoting living conditions. Thus, in this review we will summarize our investigations regarding the (1) immunological effects of asbestos fibers, (2) immunological effects of silica particles, and (

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“…Asbestos fibers have also been shown to cause reduced expression of NKp46 activating receptor and the release of cell-killing granules containing perforin and granzyme B in natural killer (NK) cells (Nishimura et al 2009a,b). With cytotoxic T-cells (CTL), asbestos repressed differentiation of naïve CTL to effector/memory CTL as well as their ability to proliferate (Maeda et al 2010;Kumagai-Takei et al 2013). Taking this and other earlier information together, we hypothesized that asbestos affected immunological systems in addition to impacting on epithelial and mesothelial cells in pulmonary tissues and that this inactivated host responses against any induced tumor cells.…”

Section: Introductionmentioning

confidence: 99%

FoxO1 regulates apoptosis induced by asbestos in the MT-2 human T-cell line

Matsuzaki

Lee

Maeda

et al. 2016

Journal of Immunotoxicology

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Asbestos is known to cause malignant mesothelioma and lung cancer. Recent studies implicate tumor immunity in the development of various tumors, including malignant mesothelioma. In order to establish an in vitro T-cell model to clarify the effects of long-term exposure of asbestos on tumor immunity, in this study, human T-cell line MT-2 cells were cultured with asbestos for longer than 8 months and the resultant cells (MT-2Rst) were assessed for the expression of forkhead transcription factor FoxO1. Gene expression analysis revealed that the amount of FoxO1 mRNA decreased after long-term exposure of the MT-2 cells to asbestos. In accordance with this reduction in FoxO1, pro-apoptotic Foxo1 target genes Puma, Fas ligand and Bim were also seen to be downregulated in MT-2Rst cells. Furthermore, shRNA-mediated knock-down of FoxO1 reduced the number of apoptotic parental MT-2 cells after treatment with asbestos. On the other hand, overexpression of FoxO1 did not affect asbestos-induced apoptosis in MT-2Rst cells. These results suggested that FoxO1 played an important role in regulating asbestos-induced apoptosis and confirmed the presence of multiple pathways regulating resistance to asbestos in MT-2Rst cells.ARTICLE HISTORY

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Dysregulation of the immune system caused by silica and asbestos

Cited by 84 publications

References 92 publications

High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

FoxO1 regulates apoptosis induced by asbestos in the MT-2 human T-cell line

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