DMSO: Applications in plastic surgery

“…Decrease of serum MDA following DMSO therapy in rat model of GS-induced nephrotoxicity may be due to inhibition of ROS or increase of renal tissue antioxidant enzymes. In addition, our results may be contributed to hydroxyl scavenging property of DMSO (18).…”

Section: Discussionmentioning

confidence: 61%

“…DMSO showed antioxidant and anti-inflammatory properties in many studies (9)(10)(11)(12). DMSO molecule has free electron pairs that makes it a powerful receptor of free radicals, especially hydroxyl radical (18).…”

Section: Discussionmentioning

confidence: 99%

Effect of dimethyl sulfoxide in combat with gentamicin induced nephrotoxicity in rats

et al. 2019

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Introduction: Gentamicin sulphate (GS) induces nephrotoxicity by increasing of reactive oxygen species (ROS). Objectives: The aim of this research was to assess the renoprotective effect of dimethyl sulfoxide (DMSO) as an antioxidant agent against GS-induced nephrotoxicity. Materials and Methods: Forty male rats (Sprague-Dawley) were divided equally in to five groups and were treated as follows; group 1; received normal saline and served as normal controls, group 2; received GS (100 mg/kg/d), groups 3; received GS and DMSO (0.5 mL/kg/d), groups 4; received GS and DMSO (1 mL/kg/d), groups 5; received GS and DMSO (2 mL/kg/d). After eight days of treatment, serum was prepared. Paraffin sections (3 µ thickness) were prepared from the left kidneys and stained through periodic acid-Schiff (PAS) method. Serum creatinine and urea were assessed by the kits and serum malondialdehyde (MDA) was assessed by thiobarbituric acid (TBA) test. Volume density of proximal tubules, tubular necrosis, tubular cast and lymphocyte infiltration were evaluated histopathologically. The data were analyzed by Mann-Whitney U test at P< 0.05 by SPSS 12 software. Results: Serum MDA, creatinine, urea, tubular volume density, tubular necrosis, tubular cast and lymphocyte infiltration were ameliorated significantly in groups four and five compared with group two (P<0.05). Conclusion: DMSO improved GS-induced renal toxicity significantly through prevention of lipid peroxidation and inflammation, but could not save kidney functional tests and histological changes at the same level as that of the normal group.

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“…Skin reactions (redness, wealing) have been commonly observed with patients treated with cutaneous applications of 95‐100% DMSO (Swanson ). However, 70‐90% DMSO has been found to be useful in the treatment of patients after cosmetic plastic surgery (Young et al ) and various DMSO‐containing creams are available from online suppliers such as http://www.amazon.com. DMSO can be used for the transdermal introduction of antibiotics, steroids, or other drugs, but it also increases the uptake of pesticides and some viruses.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of urease activity in the urinary tract pathogensStaphylococcus saprophyticusandProteus mirabilisby dimethylsulfoxide (DMSO)

Deutch¹

2020

J Appl Microbiol

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Aims: Urease is a virulence factor for the urinary tract pathogens Staphylococcus saprophyticus and Proteus mirabilis. Dimethylsulfoxide (DMSO) is structurally similar to urea, used as a solvent for urease inhibitors, and an effective treatment for interstitial cystitis/bladder pain syndrome (IC/BPS). The aims of this study were to test DMSO as a urease inhibitor and determine its physiological effects on S. saprophyticus and P. mirabilis. Methods and Results: Urease activity in extracts and whole cells was measured by the formation of ammonium ions. Urease was highly sensitive to noncompetitive inhibition by DMSO (K i about 6 mmol l À1 ). DMSO inhibited urease activity in whole cells, limited bacterial growth in media containing urea, and slowed the increase in pH which occurred in artificial urine medium. Conclusions: DMSO should be used with caution as a solvent when testing plant extracts or other potential urease inhibitors. Because it can inhibit bacterial growth and delay an increase in pH, it may be an effective treatment for urinary tract infections. Significance and Impact of the Study: This is the first detailed study of the inhibition of urease by DMSO. Dimethylsulfoxide may be used to treat urinary tract infections that are resistant to antibiotics or herbal remedies.

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DMSO: Applications in plastic surgery

Cited by 15 publications

References 52 publications

Evaluation of Dimethyl Sulfoxide and Dexamethasone on Pulmonary Contusion in Experimental Blunt Thoracic Trauma

Evaluation of Dimethyl Sulfoxide and Dexamethasone on Pulmonary Contusion in Experimental Blunt Thoracic Trauma

Effect of dimethyl sulfoxide in combat with gentamicin induced nephrotoxicity in rats

Inhibition of urease activity in the urinary tract pathogensStaphylococcus saprophyticusandProteus mirabilisby dimethylsulfoxide (DMSO)

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