“…In 2013, Sharma reported DMC (2-chloro-1,3-dimethyl imidazolidinium chloride) as an activating reagent for the synthesis of biaryl ketones via acyl Suzuki cross-coupling of carboxylic acids (Scheme 11) [41]. This reaction was compatible with electron-donating and withdrawing substituents on both reaction components; however, aliphatic carboxylic acids were not compatible with the reaction conditions.…”
Section: Suzuki Cross-coupling Of Carboxylic Acidsmentioning
Acyl Suzuki cross-coupling involves the coupling of an organoboron reagent with an acyl electrophile (acyl halide, anhydride, ester, amide). This review provides a timely overview of the very important advances that have recently taken place in the acylative Suzuki cross-coupling. Particular emphasis is directed toward the type of acyl electrophiles, catalyst systems and new cross-coupling partners. This review will be of value to synthetic chemists involved in this rapidly developing field of Suzuki cross-coupling as well as those interested in using acylative Suzuki cross-coupling for the synthesis of ketones as a catalytic alternative to stoichiometric nucleophilic additions or Friedel-Crafts reactions.
“…In 2013, Sharma reported DMC (2-chloro-1,3-dimethyl imidazolidinium chloride) as an activating reagent for the synthesis of biaryl ketones via acyl Suzuki cross-coupling of carboxylic acids (Scheme 11) [41]. This reaction was compatible with electron-donating and withdrawing substituents on both reaction components; however, aliphatic carboxylic acids were not compatible with the reaction conditions.…”
Section: Suzuki Cross-coupling Of Carboxylic Acidsmentioning
Acyl Suzuki cross-coupling involves the coupling of an organoboron reagent with an acyl electrophile (acyl halide, anhydride, ester, amide). This review provides a timely overview of the very important advances that have recently taken place in the acylative Suzuki cross-coupling. Particular emphasis is directed toward the type of acyl electrophiles, catalyst systems and new cross-coupling partners. This review will be of value to synthetic chemists involved in this rapidly developing field of Suzuki cross-coupling as well as those interested in using acylative Suzuki cross-coupling for the synthesis of ketones as a catalytic alternative to stoichiometric nucleophilic additions or Friedel-Crafts reactions.
“…In the light of a previous report on antileishmanial activities of benzophenone ethers [ 24 ], structure of pentamidine which possesses ether functionality ( figure 1 ), and in continuation of our search for antileishmanial agents [ 25 – 27 ], we have synthesized a library of functionalized benzophenone ethers and evaluated their antileishmanial activities in vitro . To the best of our knowledge, compounds 1 and 2 were previously reported, while remaining compounds are new [ 28 , 29 ]. Figure 1.…”
Leishmaniasis is a vector-borne protozoan disease; it mainly originates from the bite of sandfly and initiated when parasite is transmitted to human at metacyclic flagellated promastigote form. In the current study, a synthesis of a series of 4-substituted benzophenone ethers 1–20 was carried out in good yields and their in vitro antileishmanial activities were also screened. Among synthetic derivatives, 15 compounds 1, 3, 5–12, 15 and 17–20 showed antileishmanial activities against promastigotes of Leishmania major with IC50 values in the range of 1.19–82.30 µg ml−1, and the values were compared with those of the standard pentamidine (IC50 = 5.09 ± 0.09 µg ml−1). Our study identified a series of new antileishmanial molecules as potential leads. Structures of these synthetic compounds were deduced by different spectroscopic techniques, such as 1H and 13C nuclear magnetic resonance, electron impact and high-resolution electron impact mass spectrometry and IR.
“…The latter approach was discovered first by Bumagin and co‐workers who could successfully cross‐couple acyl chlorides with arylboronic acids in the presence of PdCl 2 in aqueous acetone . Since then, several improvements on Pd‐catalyzed coupling reactions of carboxylic acids and their derivatives, including acid chlorides , anhydrides , thioesters , and 2‐pyridyl esters with boronic acids have been widely described. Most of the above protocols are homogeneous in nature suffering from several drawbacks, such as contamination of both metal and ligand residues in the final products, recovery of the catalyst, and destruction of the catalyst during the course of the reaction.…”
The Suzuki–Miyaura cross‐coupling reaction of aroyl chlorides and arylboronic acids has been carried out efficiently in the presence of Pd(II)‐salen@MWCNTs as an air‐moisture stable precatalyst. The influence of various parameters, such as solvent, temperature, and base on the reaction system, was studied. Furthermore, the catalyst can be easily recovered quantitatively by a simple filtration and reused for three consecutive runs without significant loss of its activity.
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