Leishmaniasis is a vector-borne protozoan disease; it mainly originates from the bite of sandfly and initiated when parasite is transmitted to human at metacyclic flagellated promastigote form. In the current study, a synthesis of a series of 4-substituted benzophenone ethers 1–20 was carried out in good yields and their in vitro antileishmanial activities were also screened. Among synthetic derivatives, 15 compounds 1, 3, 5–12, 15 and 17–20 showed antileishmanial activities against promastigotes of Leishmania major with IC50 values in the range of 1.19–82.30 µg ml−1, and the values were compared with those of the standard pentamidine (IC50 = 5.09 ± 0.09 µg ml−1). Our study identified a series of new antileishmanial molecules as potential leads. Structures of these synthetic compounds were deduced by different spectroscopic techniques, such as 1H and 13C nuclear magnetic resonance, electron impact and high-resolution electron impact mass spectrometry and IR.
Gram negative microorganisms can cause numerous kinds of infections and diseases and spread to people in an assortment of ways. A few categories, including E. coli, causative agent for food borne illness. V. cholera the microbes in charge of cholera is a waterborne pathogen. They can act as respiratory tract contaminants, for example, specific sorts of pneumonia and explicitly transmitted sicknesses, and urinary tract infections like gonorrhea [1].
E. coli is a Gram-negative rod shaped enteric bacterium, dominating species among all the facultative anaerobes of the gastrointestinal tract i.e. dominant flora possessing the human colonic area. Their species are generally classified by their virulence properties, systems of pathogenicity, clinical disorders, and O and H serotypes [1]. Although most species are harmless to the intestinal lumen, some procured harmfulness factors and can cause a wide scope of human diseases [2]. The pathogenic E.coli is causative agent of three clinical syndromes: Urinary Tract Infections, Enteric/Diarrheal Diseases, and Meningitis [3].
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