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Abstract

The relative content of myocyte-active factors and endogenous muscarinic receptor blocker in the blood increased, while the concentration of endogenous beta-adrenoceptor sensitizer decreased in coronary patients with a history of acute myocardial infarction. Physical training produced a therapeutic effect, normalized the content of these factors and, probably, improved beta-adrenergic and muscarinic cholinergic regulation of the heart and vessels.

Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach

“…lysoPC increased the muscarinic cholinergic reactivity of the myocardium, while in high concentration (100 µM) lysoPC (similarly to blood plasma) decreased this parameter [5]. Further studies showed that human plasma in some dilutions (1:50, 1:100, 1:500, and 1:1000) decreases muscarinic cholinergic reactivity of rat myometrium [8], frog myocardium [9], and rat stomach [3]. This effect was associated with the presence of an endogenous muscarinic cholinoceptor antagonist in the blood.…”