dl-Propargylglycine protects against myocardial injury induced by chronic intermittent hypoxia through inhibition of endoplasmic reticulum stress

Zhou, Xin; Tang, Si; Hu, Ke; Zhang, Zhan; Liu, Pei; Luo, Yuchuan; Kang, Jian; Xu, Liang

doi:10.1007/s11325-018-1656-0

Cited by 17 publications

(8 citation statements)

References 49 publications

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“…Among the findings of this study was that pretreatment with PAG significantly improved cardiac function in CIH model rats (CIH + PAG group) compared with the CIH-only group. Moreover, levels of oxidative stress, ER stress and apoptosis were significantly lower in the CIH + PAG group compared with the CIH-only group [66]. In another study in rats that addressed cardiovascular morbidity, protein expression of the proapoptotic ER stress markers, BiP, p-PERK, ATF4 and CHOP, were increased in CIH.…”

Section: Intermittent Hypoxia and Obstructive Sleep Apneamentioning

confidence: 90%

Impact of Endoplasmic Reticulum Stress in Otorhinolaryngologic Diseases

Jung

Kim

Yeo

2020

IJMS

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The endoplasmic reticulum (ER) is an important organelle for normal cellular function and homeostasis in most living things. ER stress, which impairs ER function, occurs when the ER is overwhelmed by newly introduced immature proteins or when calcium in the ER is depleted. A number of diseases are associated with ER stress, including otorhinolaryngological diseases. The relationship between ER stress and otorhinolaryngologic conditions has been the subject of investigation over the last decade. Among otologic diseases associated with ER stress are otitis media and hearing loss. In rhinologic diseases, chronic rhinosinusitis, allergic rhinitis, and obstructive sleep apnea are also significantly associated with ER stress. In this review, we provide a comprehensive overview of the relationship between ER stress and otorhinolaryngological diseases, focusing on the current state of knowledge and mechanisms that link ER stress and otorhinolaryngologic diseases.

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Section: Intermittent Hypoxia and Obstructive Sleep Apneamentioning

confidence: 90%

Impact of Endoplasmic Reticulum Stress in Otorhinolaryngologic Diseases

Jung

Kim

Yeo

2020

IJMS

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“…There is an extensive body of literature on the protective effects of H 2 S and H 2 S donors against ischemia and the efficacy of these compounds to pre- and post-condition the myocardium as well as the central nervous system, liver, kidney and other organs and tissues. While this implies that ischemic conditioning increases cellular H 2 S, which then initiates appropriate effector responses, this is rarely examined and results are on occasion contradictory (e.g., [ 164 , 165 ]). Nevertheless, these studies are indicative of the importance of the O 2 /H 2 S axis in health and disease and are suggestive of the role of H 2 S in O 2 sensing.…”

Section: Evidence For H 2 S Mediated O 2 Sensing In Various Organ Systems and Tissuesmentioning

confidence: 99%

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Olson

2021

Antioxidants

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The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H2S) and polysulfides, collectively referred to as reactive sulfur species (RSS) as a physiologically relevant O2 sensing mechanism. This hypothesis is based on observations that H2S and RSS metabolism is inversely correlated with O2 tension, exogenous H2S elicits physiological responses identical to those produced by hypoxia, factors that affect H2S production or catabolism also affect tissue responses to hypoxia, and that RSS efficiently regulate downstream effectors of the hypoxic response in a manner consistent with a decrease in O2. H2S-mediated O2 sensing is then compared to the more generally accepted reactive oxygen species (ROS) mediated O2 sensing mechanism and a number of reasons are offered to resolve some of the confusion between the two.

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“…Furthermore, inhibitors of enzymes H 2 S synthesis can be used in order to reduce pathologically high concentrations of H 2 S. These inhibitors include DLpropargylglycine with high lipophilic properties that allow the inhibitor to pass easily through cell membrane without causing noticeable damage to it [237]. However, DLpropargylglycine is characterized by low selectivity and inhibits not only CSE, which is an enzyme of H 2 S synthesis in the cardiovascular system, but also CBS in neurons, affecting the central nervous system function [238].…”

Section: Clinical Significance Of Donors and Inducers Of H 2 Smentioning

confidence: 99%