Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman

Sparenborg, Steven; Brennecke, Lucas H.; Jaax, Nancy K.; Braitman, David J.

doi:10.1016/0028-3908(92)90068-z

Cited by 97 publications

(40 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that systemic application of sublethal doses of AChE inhibitors (AChEIs) may result in seizures, convulsions, and central nervous system lesions (21). These finding are in agreement with our results, which showed that dichlorvos at a dose of 50 mg/kg and physostigmine at a dose of 2 mg/kg caused convulsion and death in all animals.…”

Section: Discussionsupporting

confidence: 93%

RETRACTED ARTICLE: Cromakalim, a Potassium Channel Opener, Ameliorates Organophosphate- and Carbamate-Induced Seizures in Mice

et al. 2017

View full text Add to dashboard Cite

Background: Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and death. The anticonvulsant properties of potassium channel openers, including cromakalim, have been determined in previous studies. Methods: In the present experiment, the possible effects of cromakalim on convulsion and death, induced by OPs and carbamates, were studied in mice. Dichlorvos as an OP compound (50 mg/kg) and physostigmine as a carbamate (2 mg/kg) were used to induce seizure in animals.

show abstract

Section: Discussionsupporting

confidence: 93%

RETRACTED ARTICLE: Cromakalim, a Potassium Channel Opener, Ameliorates Organophosphate- and Carbamate-Induced Seizures in Mice

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In most of the published studies, NMDA antagonists were found capable of preventing seizures and lethality induced by multiple chemicals. [36][37][38][39][40] Similarly, in the present study, NMDA induced convulsions in mice and MK-801 significantly protected against these convulsions. Sanjoinine A was also effective in preventing the occurrence of EEG seizure-form activity in NMDA-treated rats.…”

Section: Discussionsupporting

confidence: 64%

Protective Effects of Sanjoinine A against N-Methyl-D-aspartate-Induced Seizure

Yun

Nam

et al. 2008

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

“…9 Furthermore, Glu receptor antagonists in general, and N-Methyl-D-aspartate (NMDA) blockers in particular, were proposed as potential antidotes against organophosphates intoxication. 10 Moreover, De Groot et al 11 showed a reduction in the brain damage post soman exposure in animals treated with a competitive NMDA antagonist. N-Methyl-Daspartate blockers were also shown to be potent protective agents against neuronal loss caused by cholinergic seizures.…”

Section: Introductionmentioning

confidence: 99%

Blood Glutamate Scavenging as a Novel Neuroprotective Treatment for Paraoxon Intoxication

Ruban

Jona

Teichberg

2013

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Organophosphate-induced brain damage is an irreversible neuronal injury, likely because there is no pharmacological treatment to prevent or block secondary damage processes. The presence of free glutamate (Glu) in the brain has a substantial role in the propagation and maintenance of organophosphate-induced seizures, thus contributing to the secondary brain damage. This report describes for the first time the ability of blood glutamate scavengers (BGS) oxaloacetic acid in combination with glutamate oxaloacetate transaminase to reduce the neuronal damage in an animal model of paraoxon (PO) intoxication. Our method causes a rapid decrease of blood Glu levels and creates a gradient that leads to the efflux of the excess brain Glu into the blood, thus reducing neurotoxicity. We demonstrated that BGS treatment significantly prevented the peripheral benzodiazepine receptor (PBR) density elevation, after PO exposure. Furthermore, we showed that BGS was able to rescue neurons in the piriform cortex of the treated rats. In conclusion, these results suggest that treatment with BGS has a neuroprotective effect in the PO intoxication. This is the first time that this approach is used in PO intoxication and it may be of high clinical significance for the future treatment of the secondary neurologic damage post organophosphates exposure.

show abstract

Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman

Cited by 97 publications

References 18 publications

RETRACTED ARTICLE: Cromakalim, a Potassium Channel Opener, Ameliorates Organophosphate- and Carbamate-Induced Seizures in Mice

RETRACTED ARTICLE: Cromakalim, a Potassium Channel Opener, Ameliorates Organophosphate- and Carbamate-Induced Seizures in Mice

Protective Effects of Sanjoinine A against N-Methyl-D-aspartate-Induced Seizure

Blood Glutamate Scavenging as a Novel Neuroprotective Treatment for Paraoxon Intoxication

Contact Info

Product

Resources

About