Protective Effects of Sanjoinine A against N-Methyl-D-aspartate-Induced Seizure

Ma, Yi; Yun, Sung-Ryul; Nam, Sang-Yoon; Kim, Yun-Bae; Jiang, Hong; Kim, Young-Hoon; Choi, Heesuk; Lee, Ki-Nam; Oh, Ki‐Wan

doi:10.1248/bpb.31.1749

Cited by 16 publications

(16 citation statements)

References 56 publications

(38 reference statements)

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“…The flavonoids (Fernandez et al, 2006;Nassiri-Asl et al, 2007), terpenoids (Muceniece et al, 2008), alkaloids (Ma et al, 2008) and coumarins (Amin et al, 2008) are reported to have anticonvulsant activity. Earlier work in our laboratory has already scientifically proved that one-week administration of both ethyl acetate (EA) and chloroform extract (200 and 400 mg/kg, p.o.)…”

Section: Introductionmentioning

confidence: 99%

Antiepileptic potential of flavonoids fraction from the leaves of Anisomeles malabarica

Choudhary

Bijjem

Kalia

2011

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Antiepileptic potential of flavonoids fraction from the leaves of Anisomeles malabarica

Choudhary

Bijjem

Kalia

2011

Journal of Ethnopharmacology

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“…The traditional therapeutic effect of sour jujube is for treatment of insomnia and anxiety, as well as for pain-relieving and anticonvulsant (Guo et al 2011;Han et al 2009;Ma et al 2008). As for functional components, they include alkaloids (sanjoinine A), flavonoids, saponins (jujubosides), and fatty acids (Cao et al 2010;Ma et al 2008;Zhao et al 2006a). …”

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confidence: 99%

Functional components in Zizyphus with emphasis on polysaccharides

Kao

Chen

2014

Polysaccharides

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Zizyphus jujuba (Chinese jujube), mainly distributed in the subtropical regions of Asia, has been cultivated for over 4,000 years and used as food, food additive, flavor, as well as traditional Chinese herb, as it possesses analeptic, palliative, and antibechic functions. The fruit of jujube is quite popular due to high nutritional value and presence of many functional components, in which polysaccharide is the most important one. Polysaccharides, being essential constituents of all living organisms, are naturally occurring polymers of aldoses and ketoses linked together through glycosidic linkages. In recent years, polysaccharides of plant origin have emerged as a vital class of bioactive nature products; however, there is a lack of information regarding analysis and biological activity of jujube polysaccharides. Moreover, the composition of polysaccharides in jujube may vary with different species, growth environment, cultivar variety, and extraction and separation methods, which in turn may affect the overall biological activity. The objective of this manuscript is to review the current status associated with jujube polysaccharide, including nutritional and functional components; methods of extraction, purification, separation, identification, and quantitation; as well as biological activity.

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“…Sanjoinine A inhibited NMDA-induced seizures, but the mechanisms were not clear (Ma et al, 2008). We have reported that the pharmacological effects of sanjoinine A have been related to GABAergic transmission Ma et al, 2008). So, we hypothesize that the protective effects of sanjoinine A against KA-induced convulsion are involved to GABA receptors/chloride channels.…”

Section: Introductionmentioning

confidence: 93%

“…Moreover, the water extract of SZS protects against NMDA-induced neuronal cell damage (Park et al, 2004). Sanjoinine A inhibited NMDA-induced seizures, but the mechanisms were not clear (Ma et al, 2008). We have reported that the pharmacological effects of sanjoinine A have been related to GABAergic transmission Ma et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…spinosa (Rhamnaceae), is a herb traditionally used for the treatment of insomnia, anxiety, and childhood convulsions in oriental countries (Peng et al, 2000). SZS has tranquilizer-like effects, and the methanol extract of SZS and sanjoinine A, a compound isolated from SZS, have anxiolytic effects via GABA receptors (Adzu et al, 2002;Han et al, 2009;Ma et al, 2008). Moreover, the water extract of SZS protects against NMDA-induced neuronal cell damage (Park et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Sanjoinine a isolated from Semen Zizyphi Spinosi protects against kainic acid-induced convulsions

Yoon

Yang

et al. 2009

Arch. Pharm. Res.

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These experiments were performed to know whether sanjoinine A, a component of the alkaloid fraction of Semen Zizyphi Spinosi, acts as an anti-convulsive agent in the kainic acid (KA)-induced experimental convulsion model and whether these effects are mediated by decreased intracellular calcium. Oral administration of sanjoinine A (4 and 8 mg/kg) increased the survival rate and latency of convulsion onset, and decreased the seizure scores and the weight loss induced by intraperitoneal (i.p.) injection of KA (50 mg/kg) in mice. In addition, sanjoinine A protected against neuronal damage and apoptosis in the hippocampus after KA administration, as analyzed by using immunohistochemistry and TUNEL assay. Sanjoinine A also significantly blocked seizure-form electroencephalogram alterations induced by KA. Moreover, in cultured rat neuronal cells, sanjoinine A inhibited KA-induced cell death, as measured by propidium iodide detection. Sanjoinine A also increased intracellular chloride and inhibited the elevation of intracellular calcium induced by KA. Sanjoinine A, therefore protects against KA-induced convulsions by increasing intracellular chloride and reducing intracellular calcium levels.

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Protective Effects of Sanjoinine A against N-Methyl-D-aspartate-Induced Seizure

Cited by 16 publications

References 56 publications

Antiepileptic potential of flavonoids fraction from the leaves of Anisomeles malabarica

Antiepileptic potential of flavonoids fraction from the leaves of Anisomeles malabarica

Functional components in Zizyphus with emphasis on polysaccharides

Sanjoinine a isolated from Semen Zizyphi Spinosi protects against kainic acid-induced convulsions

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