Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Abstract

Prophylactic dixyrazine is an effective, safe, and cheap antiemetic drug for laparoscopic cholecystectomy without involving any significant adverse events.

A systematic review of interventions to facilitate ambulatory laparoscopic cholecystectomy

“…Additionally, in patients given gabapentin, fentanyl requirements were reduced, which is consistent with the previously reported opioid‐sparing effects of this treatment 75 . The efficacy of dixyrazine, a phenothiazine derivative, was studied by Glaser et al 76 . in a trial of 197 patients.…”

“…Eight studies 7,70–76 evaluated the efficacy of different anti‐emetic regimens in patients undergoing LC. Two placebo‐controlled trials 7,73 showed serotonergic antagonists such as ondansetron to be effective in reducing postoperative nausea 7 and vomiting 7,73 .…”

“…Additionally, in patients given gabapentin, fentanyl requirements were reduced, which is consistent with the previously reported opioid-sparing effects of this treatment. 75 The efficacy of dixyrazine, a phenothiazine derivative, was studied by Glaser et al 76 in a trial of 197 patients. The authors reported significantly more patients without PONV and fewer patients requiring rescue analgesia in the dixyrazine group.…”

Comparison of dexamethasone, metoclopramide, and their combination in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

“…Patients undergoing laparoscopic cholecystectomy are especially prone to PONV, with a reported incidence of 53%-72% [20,22,23,25]. In various attempts to decrease this high incidence, numerous antiemetics have been studied [9,10,22]. However, because of the multifactorial origin of PONV, none of the currently available antiemetics is fully effective in all patients.…”

Practice Guidelines for Postanesthetic Care

“…13,35,37,39 One new RCT indicates that dixrazine is effective in the prophylaxis of postoperative nausea when compared with placebo (Category A3-B evidence), with equivocal findings reported for postoperative vomiting, headache, dizziness, and anxiety (Category A3-E evidence). 40 New literature is insufficient to further evaluate postoperative nausea and vomiting findings, as reported in the original Guidelines, for the following drugs: hydroxizine (Category A3-B evidence), perphenazine (Category A3-B evidence), and prochlorperazine (Category…”