Dixon-based fat-free MR-angiography compared to first pass and steady-state high-resolution MR-angiography using a blood pool contrast agent

Homsi, Rami; Gieseke, Jürgen; Kukuk, G; Träber, Frank; Willinek, Winfried A.; Schild, Hans H.; Hadizadeh, Dariusch R.

doi:10.1016/j.mri.2015.07.005

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…In our study, the diagnostic yield of mDixon in depicting the pulmonary and neck veins was consistently comparable to that of the CE-CMRA and higher than the bSSFP. Our results are in line with existing adult literature showing high spatial resolution and vessel-to-background contrast in imaging of peripheral arteries via Dixon-based fat-free CMRA [24, 25]. The clinical relevance of applying mDixon sequences consists in providing high quality intracardiac information simultaneously with arterial and venous vascular data, including not only the pulmonary and neck veins, but also collateral vessels that play a pivotal role for targeted therapeutic interventions.…”

Section: Discussionsupporting

confidence: 88%

“…Unlike bSSFP, fat-water separation Dixon-based methods include the underlying B 0 distribution in the signal model; therefore image acquisition is less susceptible to field inhomogeneity [16–19]. Modified Dixon (mDixon) CMRA has excellent image quality at 1.5 T and improve vessel-lumen to fat contrast [20], assist in identifying intramyocardial fatty infiltration in arrhythmogenic right ventricular cardiomyopathy [21, 22], quantify pericardial and epicardial fat in patients with high-risk cardiovascular disease profile [23], and help in the characterization of peripheral arterial occlusive disease [24, 25]. mDixon strategies to reduce artifacts introduced by metal-implants have been a primary focus of musculoskeletal MRI following hip-replacement surgery [26].…”

Section: Introductionmentioning

confidence: 99%

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mDixon ECG-gated 3-dimensional cardiovascular magnetic resonance angiography in patients with congenital cardiovascular disease

Kourtidou

Jones

Moore

et al. 2019

Journal of Cardiovascular Magnetic Resonance

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Background Cardiovascular magnetic resonance (CMR) angiography (CMRA) is an important non-invasive imaging tool for congenital heart disease (CHD) and aortopathy patients. The conventional 3D balanced steady-state free precession (bSSFP) sequence is often confounded by imaging artifacts. We sought to compare the respiratory navigated and electrocardiogram (ECG) gated modified Dixon (mDixon) CMRA sequence to conventional non-gated dynamic multi-phase contrast enhanced CMRA (CE-CMRA) and bSSFP across a variety of diagnoses. Methods We included 24 patients with CHD or aortopathy with CMR performed between September 2017 to December 2017. Each patient had undergone CE-CMRA, followed by a bSSFP and mDixon angiogram. Patients with CMR-incompatible implants or contraindications to contrast were excluded. The studies were rated according to image quality at a scale from 1 (poor) to 4 (excellent) based on diagnostic adequacy, artifact burden, vascular border delineation, myocardium-blood pool contrast, and visualization of pulmonary and systemic veins and coronaries. Contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR) and quantitative vascular measurements were compared between the two gated sequences. Bland-Altman plots were generated to compare paired measures. Results All scans were diagnostically adequate. Mean (SD) quality scores were 3.4 (0.7) for the mDixon, 3.2 (0.5) for the bSSFP and 3.4 (0.5) for the CE-CMRA. Qualitatively, the intracardiac anatomy and myocardium-blood pool definition were better in the bSSFP; however, mDixon images showed enhanced vessel wall sharpness with less blurring surrounding the anatomical borders distally. Coronary origins were identified in all cases. Pulmonary veins were visualized in 92% of mDixon sequences, 75% of bSSFP and 96% of CE-CMRA. Similarly, neck veins were identified in 92, 83 and 96% respectively. Artifacts prevented vascular measurement in 6/192 (3%) and 4/192 (2%) of total vascular measurements for the mDixon and bSSFP, respectively. However, the size of signal void and field distortion were significantly worse in the latter, particularly for flow and metal induced artifacts. Conclusion In patients with congenital heart disease, ECG gated mDixon angiography yields high fidelity vascular images including better delineation of head and neck vasculature and pulmonary veins and fewer artifacts than the comparable bSSFP sequence. It should be considered as the preferred strategy for successful CHD imaging in patients with valve stenosis, vascular stents, or metallic implants. Electronic supplementary material The online version of this article (10.1186/s12968-019-0554-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

mDixon ECG-gated 3-dimensional cardiovascular magnetic resonance angiography in patients with congenital cardiovascular disease

Kourtidou

Jones

Moore

et al. 2019

Journal of Cardiovascular Magnetic Resonance

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“…Dixon imaging for CE‐MRA has recently gained interest as it: (1) reduces and ideally eliminates the bright fat signal that can obscure vasculature, (2) accounts for main magnetic field inhomogeneity, and offers (3) better motion immunity and (4) in some cases improved SNR and contrast‐to‐noise ratio when compared to subtraction‐based background suppression. The last of these points, the improvement in SNR and contrast‐to‐noise ratio, was examined in detail with theoretical derivations and verified experimentally in phantom/in vivo studies in Ref.…”

Section: Introductionmentioning

confidence: 99%

“…Fat suppression with short-tau inversion recovery 2 or spectrally selective radiofrequency (RF) pulses 3,4 can selectively suppress lipid signal, but these methods also extend scan time or reduce temporal resolution for dynamic imaging and can be sensitive to main magnetic field inhomogeneity (DB 0 ). Dixon imaging 5 for CE-MRA [6][7][8][9][10][11][12][13][14] has recently gained interest as it: (1) reduces and ideally eliminates the bright fat signal that can obscure vasculature, (2) accounts for main magnetic field inhomogeneity, and offers (3) better motion immunity 9 and (4) in some cases improved SNR and contrast-to-noise ratio 9,12 when compared to subtraction-based background suppression. The last of these points, the improvement in SNR and contrast-to-noise ratio, was examined in detail with theoretical derivations and verified experimentally in phantom/in vivo studies in Ref.…”

Section: Introductionmentioning

confidence: 99%

Time‐resolved contrast‐enhanced MR angiography with single‐echo Dixon fat suppression

Stinson

Trzasko

Campeau

et al. 2018

Magnetic Resonance in Med

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“…[9] However, the Dixon method requires longer scan times and has lower scan parameter flexibility. The modified Dixon (mDixon) method overcomes these disadvantages [10] and has proven to be clinically useful in various MRA applications [11][12][13][14] but has not been fully evaluated in MRA of the neck. Based on its lower sensitivity to blood turbulence, we hypothesized that mDixon-based noncontrast MRA can provide a sharp and clear depiction of the carotid artery than conventional TOF-MRA.…”

Section: Introductionmentioning

confidence: 99%

Non-contrast mDixon MR angiography of the neck

Mizoshiri¹,

Yoshida²,

Oda³

et al. 2021

Medicine

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We investigated the feasibility of non-contrast three-dimensional modified Dixon (mDixon) magnetic resonance angiography (MRA) to evaluate the carotid artery. We studied 30 normal patients who underwent non-contrast mDixon and conventional time-of-flight (TOF) MRA of the neck with a clinical 3T MR scanner. Carotid artery signal-to-noise ratio (SNR) and contrast-to-noise ratio were compared between mDixon-MRA and TOF-MRA. Two readers independently evaluated vessel sharpness, image contrast, and overall image quality using a 4-point scale. SNR was significantly higher on mDixon-MRA than TOF-MRA ( P < .01). There was no significant difference in contrast-to-noise ratio. The visual score for vessel sharpness was significantly higher on mDixon-MRA than TOF-MRA ( P < .01), whereas the score for contrast was significantly higher on TOF-MRA ( P < .01). Although non-contrast three-dimensional mDixon-MRA showed lower visual contrast than conventional TOF-MRA, it provided images with significantly higher SNR and better vessel sharpness than TOF-MRA.

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Dixon-based fat-free MR-angiography compared to first pass and steady-state high-resolution MR-angiography using a blood pool contrast agent

Cited by 5 publications

References 28 publications

mDixon ECG-gated 3-dimensional cardiovascular magnetic resonance angiography in patients with congenital cardiovascular disease

mDixon ECG-gated 3-dimensional cardiovascular magnetic resonance angiography in patients with congenital cardiovascular disease

Time‐resolved contrast‐enhanced MR angiography with single‐echo Dixon fat suppression

Non-contrast mDixon MR angiography of the neck

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