Divided nevus of the eyelid: Review of embryology, pathology and treatment

Large Congenital Melanocytic Nevus on the Breast Sparing the Nipple and Areola

“…A unique CMN located on the opposing margins of the lower and upper eyelids of the same eye, showing a continuous pattern when the eyelids are closed, is called a “divided nevus” or a “kissing nevus”. This distinctly located nevus is classically accepted as an indicator of the occurrence of CMN in utero during early embryogenesis .…”

Amniotic membrane graft to reconstruct divided nevi of eyelids

“…Overall, there are only four studies which enrolled more than 10 patients 2. Hence, no guidelines for the reconstruction have been laid down which could be used primarily.…”

“…These symmetrical pigmented lesions on both the upper and lower eyelids of one eye appear to be ‘single’ when the eyelids are closed, hence their popular name ‘kissing nevi’. They are also known as ‘paired nevi’, ‘panda nevi or ‘split ocular nevi’ 2. However, ‘divided nevi’ are a well-established entity in the lexicon.…”

“…Morphological and histological classification states medium sized (1.5–2.0 cm) and melanocytic intradermal type to be the most commonly reported divided nevi of the eyelids 2. The embryological development of this lesion occurs around the 12–14th week of gestation when the eyelids are still fused and migration of melanocytes from melanoblasts takes place.…”

Evaluation of the umbilical sparing phenomenon of large congenital melanocytic nevi in a large case series

“…Melanocytic nevi occur anywhere on the body where melanocytes are present, and nevi in special locations are always of particular interest to clinicians [ 1 ] . In addition, the continuous growth of nevi on opposing margins of certain (divided) body parts [ 2 ] , as well as the focal sparing of certain areas of the body, may be important observations with regard to understanding the pathogenetic aspects of these benign tumors. Congenital melanocytic nevi are extremely rare in the nipple/ areola region, and only two case reports of small nevi located in this area have been reported in the relevant literature [ 3 ] .…”