Diversity of clinical appearance of cutaneous manifestations in the course of COVID‐19

Guarneri, Claudio; Rullo, Emmanuele Venanzi; Gallizzi, Romina; Ceccarelli, Manuela; Cannavò, Serafinella Patrizia; Nunnari, Giuseppe

doi:10.1111/jdv.16669

Cited by 46 publications

(66 citation statements)

References 7 publications

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“…These considerations could explain the wide variations in the prevalence of cutaneous lesions reported in patients with SARS-CoV-2 infection ranging from 0.2% to 20.4%. [5][6][7][8][9][10][11][12] Distinct cutaneous clinical patterns have been associated with COVID-19. They appear at different times in the disease course and are associated with different duration, severity and prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…The conspicuous numbers of case reports and clinical series that have been recently published have described a complex spectrum of skin manifestations associated with the infection. [4][5][6][7][8][9][10][11][12] The aim of this review is to summarize the major patterns of dermatological manifestations associated with SARS-CoV-2 virus infection.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous manifestations of SARS‐CoV‐2 infection: a clinical update

Gisondi

Piaserico

Bordin

et al. 2020

Acad Dermatol Venereol

120

124

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On March 11 th , 2020, the World Health Organization (WHO) has declared the novel coronavirus disease (COVID‐19) a global pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 virus). A consistent number of case reports and clinical series have been already published describing a complex spectrum of skin manifestations associated with the SARS‐CoV‐2 infection. We carried out a review of the English‐language literature up to May 20th 2020, reporting original cases or case series of the cutaneous manifestations of SARS‐CoV‐2 virus infection. The following databases were consulted PubMed, Embase, Google Scholar, ResearchGate. The search of papers was conducted by using the key term ‘COVID‐19’ or ‘SARS‐CoV‐2’ or ‘coronavirus’ combined with each of the following: ‘skin’, ‘cutaneous’, ’dermatologic’ or ‘dermatology’, ‘manifestation’, ‘lesions,’ or ‘rash.’ The patterns of dermatological manifestations associated with SARS‐CoV‐2 infection could be classified into four categories: exanthema (varicella‐like, papulo‐vesicular and morbilliform rash), vascular (chilblain‐like, purpuric/petechial and livedoid lesions), urticarial and acro‐papular eruption. Lastly, other skin manifestations to be considered are the cutaneous adverse reactions to the drugs prescribed for the treatment of COVID‐19. Whether SARS‐CoV‐2 infection can directly cause a worsening of chronic inflammatory diseases such as psoriasis or atopic dermatitis remains to be determined. Dermatology’s outlook in the COVID‐19 pandemic is multidimensional.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cutaneous manifestations of SARS‐CoV‐2 infection: a clinical update

Gisondi

Piaserico

Bordin

et al. 2020

Acad Dermatol Venereol

120

124

View full text Add to dashboard Cite

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“…Acral cutaneous lesions ("COVID toes") including chilblainlike lesions and those resembling pernio are likely interchangeable terms for similar or identical pathological findings in COVID-19. Acral lesions are mostly reported in pediatric patients with asymptomatic or mild disease, but may be found in adults with SARS-CoV-2 infection [22,23,[68][69][70]. Chilblain-like lesions occur in adult patients with COVID-19 disease in 19-40% of cases [3,4,23].…”

Section: Chilblain-like Eruptions and Acral Lesionsmentioning

confidence: 99%

Cutaneous Manifestations in Adult Patients with COVID-19 and Dermatologic Conditions Related to the COVID-19 Pandemic in Health Care Workers

Mawhirt

Frankel

Diaz³

2020

Curr Allergy Asthma Rep

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Purpose of Review COVID-19 (coronavirus viral disease 2019), due to the novel SARS-CoV-2, may present with different types of cutaneous manifestations of varying pathophysiology. During the ongoing pandemic, publications reporting dermatologic findings in COVID-19 continue to emerge. Recent Findings Cutaneous vasculopathy and microthrombus-related changes including acral and sacral lesions, retiform purpura, livedo reticularis, and cutaneous vasculitis are notable findings in adult patients. Other exanthems include urticaria or angioedema, morbilliform/maculopapular exanthems, erythema multiforme, and vesicular eruptions. Increased recognition of these findings, especially those consistent with cutaneous microthrombi or vasculitis, is of particular importance. Additionally, occupational dermatologic disease related to extended personal protective equipment (PPE) use, such as skin damage and irritant or allergic contact dermatitis (ACD), represents another emerging problem amidst the pandemic. Summary In this review, we highlight the various cutaneous manifestations associated with COVID-19 in adult patients and occupational dermatitis in health care workers (HCWs) caring for this patient population. Keywords COVID-19. SARS-CoV-2. Cutaneous manifestations. Dermatologic. Rash. Contact dermatitis Abbreviations AAD American Academy of Dermatology ACD Allergic contact dermatitis ACE2 Angiotensin-converting enzyme 2 AD Atopic dermatitis AGEP Acute generalized exanthematous pustulosis ARDS Acute respiratory distress syndrome COVID-19 Coronarvirus viral disease 2019 CSSV Cutaneous small vessel vasculitis DIC Disseminated intravascular coagulation DiHS/DRESS Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms HCW Health care worker ICD Irritant contact dermatitis ITP Immune thrombocytopenic purpura PPE Personal protective equipment PT Patch test RT-PCR Reverse transcriptase polymerase chain reaction SARS-CoV-2 Severe acute respiratory distress syndrome coronavirus 2 SDRIFE Symmetrical drug-related intertriginous and flexural exanthema This article is part of the Topical Collection on Allergic Skin Diseases

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“…After eliminating the overlaps between the two search engines, we were left with 23 works investigating the relationships between SARS-CoV-2 infection and urticaria. Of these, 18 reported cases of urticaria in patients with SARS-CoV-2 infection [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Unfortunately, not all studies reported the characteristics of the patients studied (gender, age, timing, etc.)…”

Section: Resultsmentioning

confidence: 99%

Urticaria and coronavirus infection a lesson from SARS-CoV-2 pandemic

Allegra

Asero

Giovannetti

et al. 2021

Eur Ann Allergy Clin Immunol

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Urticaria is a condition involving both skin and mucosal tissues characterized by the presence of wheals and/or angioedema. The acute form has been related to allergic reactions to drugs or foods, interaction with chemicals, or infections. We reviewed the association of urticaria with coronavirus infections. This review was carried out by the use of two search engines for published original articles, employing two key terms correlated to urticaria and viruses: "urticaria" and one term linked to each virus. The research of the relationships between SARS-CoV-2 and urticaria produced 18 papers (including a total of 114 cases. Surprisingly, the search for cases of urticaria in patients with SARS-CoV or MERS produced no results. We tried to interpret this discrepancy and attempted to analyze the possible pathogenesis of urticaria lesions in SARS-CoV-2.

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Diversity of clinical appearance of cutaneous manifestations in the course of COVID‐19

Cited by 46 publications

References 7 publications

Cutaneous manifestations of SARS‐CoV‐2 infection: a clinical update

Cutaneous manifestations of SARS‐CoV‐2 infection: a clinical update

Cutaneous Manifestations in Adult Patients with COVID-19 and Dermatologic Conditions Related to the COVID-19 Pandemic in Health Care Workers

Urticaria and coronavirus infection a lesson from SARS-CoV-2 pandemic

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