Diversity of Bipolaris Species in Clinical Samples in the United States and Their Antifungal Susceptibility Profiles

Cunha, Keith Cássia da; Sutton, Deanna A.; Fothergill, Annette W.; Cano, Josep; Gené, Josepa; Madrid, Hugo; Hoog, Sybren de; Crous, Pedro W.; Guarro, Josep

doi:10.1128/jcm.01965-12

Cited by 59 publications

(43 citation statements)

References 30 publications

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“…Furthermore, it may lead to infection of the peritoneum, bronchus and other debilitating conditions, including meningitis and disseminated infections (10)(11)(12)(13)(14)(15)(16)(17)(18). da Cunha et al (8) identified that Bipolaris spicifera was one of the major pathogenic species, accounting for 67.3% in all 104 clinical samples morphologically compatible with Bipolaris. Sinusitis was the most common infection, accounting for 30.7% and skin infections were the second, accounting for 19.2% of cases (8).…”

Section: Discussionmentioning

confidence: 99%

“…da Cunha et al (8) identified that Bipolaris spicifera was one of the major pathogenic species, accounting for 67.3% in all 104 clinical samples morphologically compatible with Bipolaris. Sinusitis was the most common infection, accounting for 30.7% and skin infections were the second, accounting for 19.2% of cases (8). To the best of our knowledge, the present study documents the first reported case of subcutaneous PHM caused by Bipolaris spicifera in Northern China.…”

Section: Discussionmentioning

confidence: 99%

“…Antifungal agents, including flucytosine and itraconazole, appear to be effective treatments for patients with subcutaneous phaeohyphomycosis caused by Bipolaris spicifera (8). Surgical excision has been widely used to treat subcutaneous PHM (5).…”

Section: Discussionmentioning

confidence: 99%

“…Bipolaris spicifera is typically associated with subcutaneous PHM and symptoms such as sinusitis and skin infections (7,8). The majority of cases so far have been encountered in tropical climatic zones (5).…”

Section: Introductionmentioning

confidence: 99%

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The first case of cutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China: A case report

Pan

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Phaeohyphomycosis (PHM) is a term used to describe any fungus presenting in tissues with pseudohyphae, hyphae, brown yeast-like cells or a combination of these forms. Sinusitis and skin infections are the most common presentation of subcutaneous PHM caused by the fungus Bipolaris spicifera. However, the majority of cases have so far been encountered in tropical climatic zones. The present study documents a case of subcutaneous PHM caused by infection with Bipolaris spicifera in a 56-year-old Chinese man, who presented with plaque papillomatosis on the left foot. The organism isolated from the lesion scar and tissue was identified as Bipolaris spicifera by its morphology, histopathology and DNA sequencing. The patient was successfully treated with itraconazole and terbinafine. IntroductionPhaeohyphomycosis (PHM) refers to phaeoid fungal infections with specific structures including pseudohyphae, hyphae and brown yeast-like cells seen in tissue samples (1,2). Currently, there are at least 60 genera and 109 species that can cause PHM. The most frequent etiologic agents are Exophiala spinifera, Wa ngiella spinifera, Phialophora spinifera a nd Bipolaris spinifera (3).PHM-inducing agents are widely distributed around the world; however, they are more frequently observed in tropical and subtropical climates (4). PHM occurs in immunocompromised and immunocompetent individuals, although organ transplantation, cancer, leukemia, prolonged hospitalization and corticosteroid therapy are predisposing factors (5,6). Cases of PHM have been reported in different regions such as the Caribbean islands, parts of South America, Africa, the Indian subcontinent, Southeast Asia, and the West Pacific Islands (3). The incidence in patients with solid organ transplantation is ~9% (5).PHM may be categorized as either superficial, cutaneous and corneal, subcutaneous, and systemic PHM (5). Bipolaris spicifera is typically associated with subcutaneous PHM and symptoms such as sinusitis and skin infections (7,8). The majority of cases so far have been encountered in tropical climatic zones (5). The present case, however, exhibits the first case of subcutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China, in an area with a subtropical climate. Case reportA 56-year-old Chinese male presenting with papular nodules and plaque papillomatosis on the left foot was admitted into the Department of Dermatology, Qingdao University Affiliated Hospital (Qingdao, China) in June 2014. Initial onset was characterized by the appearance of scattered papules and nodules on the dorsum of the left foot 10 years previously, without clinical symptoms. The lesion converged gradually, formed a granuloma-like lesion and spread from the hallux to the dorsum of the foot and the second, third and fourth toes, with occasional co-presentation of bloody pus. The patient also had a prior medical history of rheumatoid arthritis for one year prior to this onset. The patient was a farmer living in Shandong Province, had never traveled outside the ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The first case of cutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China: A case report

Pan

Liu

et al. 2017

Experimental and Therapeutic Medicine

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“…Bipolaris comprises a large genus of fungi with more than 100 species, most of them being saprobes in soil and pathogens of plants, and some potentially able to infect humans and animals (Sivanesan, 1987;Cunha et al, 2012). While B. oryzae is the most commonly species infecting rice seeds, likely due to its association with foliar epidemics of brown spot, other Bipolaris species have been found during routine analysis of rice seedlots around the world, including B. bicolor, B.…”

Section: Introductionmentioning

confidence: 99%

Regional and varietal differences in prevalence and incidence levels of Bipolaris species in Brazilian rice seedlots

Meneses¹,

Farias²,

Caniela³

et al. 2014

Trop. plant pathol.

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A total of 722 rice seed lots were collected at six production regions of Rio Grande do Sul state during three consecutive seasons (2009/10 to 2011/12). For each seed lot, 200 seeds were assessed for the presence of Bipolaris spp. using a standard seed health blotter test. Results showed that B. oryzae and B. cynodontis were found in 62.5% and 10.4% of the seed lots, respectively. Overall mean incidence of B. oryzae and B. cynodontis were 0.5% and 0.06%, respectively. For the two most sampled varieties (75% of the seed lots), IRGA 424 and Puitá INTA CL, mean incidence levels were highest and lowest, respectively. Among regions, infection risk was highest in the southeastern and lowest in the western regions of the state, especially the Fronteira Oeste. The prevalence and the incidence levels of Bipolaris oryzae reported in this study were lower than previous reports in the same region -eighty percent of the seed lots showed incidence levels below the recommended 5% inoculum threshold. In conclusion, rice seeds produced by IRGA-certified growers showed an overall good health quality with regards to B. oryzae infection, which is the main Bipolaris species associated with rice seeds in southern Brazil.

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Clinical and Pathologic Features ofBipolarisEndophthalmitis After Intravitreal Triamcinolone

Minckler

Small²,

Walsh

2014

JAMA Ophthalmol

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Diversity of Bipolaris Species in Clinical Samples in the United States and Their Antifungal Susceptibility Profiles

Cited by 59 publications

References 30 publications

The first case of cutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China: A case report

The first case of cutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China: A case report

Regional and varietal differences in prevalence and incidence levels of Bipolaris species in Brazilian rice seedlots

Clinical and Pathologic Features ofBipolarisEndophthalmitis After Intravitreal Triamcinolone

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