Diversity of bacterial chemosensory systems

Gumerov, Vadim M.; Andrianova, Ekaterina P.; Zhulin, Igor B.

doi:10.1016/j.mib.2021.01.016

Cited by 36 publications

(35 citation statements)

References 52 publications

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“…1B ). Nevertheless, several distinct classes of chemotaxis pathways could be distinguished based on their detailed molecular composition and evolutionary relatedness, some of which control behaviors other than flagellar motility (Gumerov, Andrianova and Zhulin 2021 ; Wuichet and Zhulin 2010 ). In contrast to many other bacteria, the genome of E. coli encodes only a single motility and chemotaxis system, which moreover functions with a nearly minimal set of chemotaxis proteins.…”

Section: Introductionmentioning

confidence: 99%

“…The signal transduction module of the chemotaxis pathway belongs to a larger family of two-component systems (TCSs) that enable environmental sensing in prokaryotes and are also present in fungi and plants (Stock, Robinson and Goudreau 2000 ). One important difference between the canonical TCSs and the chemotaxis pathways is that in the former the sensory, kinase and phosphatase activities are typically executed by a single sensory kinase protein, whereas in chemotaxis these functions are carried out by different proteins within one stable complex (Gumerov, Andrianova and Zhulin 2021 ; Sourjik and Armitage 2010 ). Such segregation of sensory and signaling activities likely facilitates evolutionary adaptation of the chemotaxis pathway to new environmental niches with different chemoeffector requirements, where specific chemoreceptors could be rapidly acquired or lost without affecting the function of the signaling core.…”

Section: Introductionmentioning

confidence: 99%

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Multiple functions of flagellar motility and chemotaxis in bacterial physiology

Colin

Laganenka

et al. 2021

FEMS Microbiology Reviews

141

102

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Most swimming bacteria are capable of following gradients of nutrients, signaling molecules and other environmental factors that affect bacterial physiology. This tactic behavior became one of the most-studied model systems for signal transduction and quantitative biology, and underlying molecular mechanisms are well characterized in Escherichia coli and several other model systems. In this review, we focus primarily on less understood aspect of bacterial chemotaxis, namely its physiological relevance for individual bacterial cells and for bacterial populations. As evident from multiple recent studies, even for the same bacterial species flagellar motility and chemotaxis might serve multiple roles, depending on the physiological and environmental conditions. Among these, finding sources of nutrients and more generally locating niches that are optimal for growth appear to be one of the major functions of bacterial chemotaxis, which could explain many chemoeffector preferences as well as flagellar gene regulation. Chemotaxis might also generally enhance efficiency of environmental colonization by motile bacteria, which involves intricate interplay between individual and collective behaviors and trade-offs between growth and motility. Finally, motility and chemotaxis play multiple roles in collective behaviors of bacteria including swarming, biofilm formation and autoaggregation, as well as in their interactions with animal and plant hosts.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multiple functions of flagellar motility and chemotaxis in bacterial physiology

Colin

Laganenka

et al. 2021

FEMS Microbiology Reviews

141

102

View full text Add to dashboard Cite

show abstract

“…There are many ways of classifying signal transduction proteins. However, one practical system for grouping the diverse GGDEF, EAL, and HD-GYP domain-containing architectures is the complexity scheme ( 31 – 33 ), which classifies signal transduction proteins into one-component, two-component, and chemosensory systems ( Fig. 2 ).…”

Section: Principles Of Sensory Perception In C-di-gmp Signalingmentioning

confidence: 99%

Sensory Perception in Bacterial Cyclic Diguanylate Signal Transduction

et al. 2022

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Cyclic diguanylate (c-di-GMP) signal transduction systems provide bacteria the ability to sense changing cell status or environmental conditions and then execute suitable physiological and social behaviours in response. In this review, we provide a comprehensive census of the stimuli and receptors that are linked to modulation of intracellular c-di-GMP. Emerging evidence indicates that c-di-GMP networks sense light, surfaces, energy, redox potential, respiratory electron acceptors, temperature, and structurally diverse biotic and abiotic chemicals. Bioinformatic analysis of sensory domains in diguanylate cyclases and c-di-GMP-specific phosphodiesterases as well as the receptor complexes associated with them reveals that these functions are linked to a diverse repertoire of protein domain families. We describe the principles of stimulus perception learned from studying these modular sensory devices, illustrate how they are assembled in varied combinations with output domains, and summarize a system for classifying these sensor proteins based on their complexity. Biological information-processing via c-di-GMP signal transduction is not only fundamental to bacterial survival in dynamic environments, but also is being used to engineer gene expression circuitry and synthetic proteins with à la carte biochemical functionalities.

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“…Usually, there are slightly more RR genes than receptor genes, and sometimes, a single receptor may regulate the activity of different RR proteins [ 3 , 6 , 7 ]. TCS may respond to ions, gases, small molecules, peptides, and other chemicals as well as to factors such as temperature, osmolarity, membrane fluidity, or illumination [ 8 , 9 , 10 , 11 ]. Since many of them are important for bacterial survival and pathogenicity, TCS constitute promising targets for antimicrobial treatments [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…HKs are usually dimeric proteins that perceive the signal and act on RR directly; RRs often regulate transcription and intracellular processes [ 23 , 24 , 26 ]. Chemoreceptors and sensory rhodopsin-based photoreceptors are involved in chemo- and phototaxis, but they can also perform other functions [ 10 , 11 , 27 , 28 ]. They form higher-order assemblies composed of trimers-of-dimers of the receptor proteins in complex with the histidine kinase CheA and accessory proteins [ 27 , 29 ]; the activity of CheA is regulated by the receptors [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Nitrate- and Nitrite-Sensing Histidine Kinases: Function, Structure, and Natural Diversity

Gushchin

Aleksenko

Orekhov

et al. 2021

IJMS

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Under anaerobic conditions, bacteria may utilize nitrates and nitrites as electron acceptors. Sensitivity to nitrous compounds is achieved via several mechanisms, some of which rely on sensor histidine kinases (HKs). The best studied nitrate- and nitrite-sensing HKs (NSHKs) are NarQ and NarX from Escherichia coli. Here, we review the function of NSHKs, analyze their natural diversity, and describe the available structural information. In particular, we show that around 6000 different NSHK sequences forming several distinct clusters may now be found in genomic databases, comprising mostly the genes from Beta- and Gammaproteobacteria as well as from Bacteroidetes and Chloroflexi, including those from anaerobic ammonia oxidation (annamox) communities. We show that the architecture of NSHKs is mostly conserved, although proteins from Bacteroidetes lack the HAMP and GAF-like domains yet sometimes have PAS. We reconcile the variation of NSHK sequences with atomistic models and pinpoint the structural elements important for signal transduction from the sensor domain to the catalytic module over the transmembrane and cytoplasmic regions spanning more than 200 Å.

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Diversity of bacterial chemosensory systems

Cited by 36 publications

References 52 publications

Multiple functions of flagellar motility and chemotaxis in bacterial physiology

Multiple functions of flagellar motility and chemotaxis in bacterial physiology

Sensory Perception in Bacterial Cyclic Diguanylate Signal Transduction

Nitrate- and Nitrite-Sensing Histidine Kinases: Function, Structure, and Natural Diversity

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