Diversified sources for human infections by Salmonella enterica serovar newport

Abstract

Salmonella enterica Newport (S. Newport), with phylogenetic diversity feature, contributes to significant public health concerns. Our previous study suggested that S. Newport from multiple animal‐borne routes, with distinct antibiotic resistant pattern, might transmit to human. However, their genetic information was lacking. As a complement to the earlier finding, we investigate the relationship between each other among the hosts, sources, genotype and antibiotic resistance in S. Newport. We used the multilocus sequence typing (MLST) in conjunction with minimum inhibitory concentration of 16 antibiotics of globally sampled 1842 S. Newport strains, including 282 newly contributed Chinese strains, to evaluate this association. Our analysis reveals that sequence types (STs) are significantly associated with different host sources, including livestock (ST45), birds (ST5), contaminated water and soil (ST118), reptiles (ST46) and seafood (ST31). Importantly, ST45 contained most of (344/553) the multi‐drug resistance (MDR) strains, which were believed to be responsible for human MDR bacterial infections. Chinese isolates were detected to form two unique lineages of avian (ST808 group) and freshwater animal (ST2364 group) origin. Taken together, genotyping information of S. Newport could serve to improve Salmonella source‐originated diagnostics and guide better selection of antibiotic therapy against Salmonella infections.

Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections

“…Both mcr-positive (ST31) and chromosome-mediated (ST46) strains have clonal linkage with seafood origin, including tilapia and octopus. The host or sampling origin was significantly associated with the particular ST, which was suggested by our previous large-scale population study [18]. We also found an isolate from ST45, a previous bovine adaptive subclade, with colistin resistance.…”

Genomic Characterization of mcr-1-carrying Salmonella enterica Serovar 4,[5],12:i:- ST 34 Clone Isolated From Pigs in China

“…Salmonella serovars have a wide host range and can be transmitted to a broad diversity of animals, including mammals, birds, fish, and insects (Pan et al, 2019). Besides, Salmonella can grow in plants and can survive in protozoa, soil, and water (Silva et al, 2014;Pan et al, 2018).…”

“…Besides, Salmonella can grow in plants and can survive in protozoa, soil, and water ( Silva et al, 2014 ; Pan et al, 2018 ). Hence, broad-host-range Salmonella can be transmitted via feces from wild animals, farm animals, and pets or by consumption of a wide variety of common foods: poultry, beef, pork, seafood, milk, fruit, and vegetables ( Pan et al, 2019 ; Elbediwi et al, 2020 ). Phylogenomic analysis of four strains, determined in this study, with all available mcr-1 -carrying S. Typhimurium and monophasic isolates from swine, poultry, humans, and environment, showed that these four strains were closely related and clustered together with four additional Chinese pork isolates and one human isolate ( Figure 4 ).…”

Genomic characterization of Salmonella Uzaramo for human invasive infection

“…NTS is primarily transmitted via commercial food or water. Contaminated raw products are also increasingly considered as an important vehicle for Salmonella dissemination, leading to foodborne outbreaks [13, 14]. Reptiles, numerous wildlife animals and, importantly, the environment contaminated by these can also serve as the reservoir for Salmonella [15, 16], which are usually found as phylogenetically diverse serovars and isolates [1, 17].…”