Diverse Systems for Pheromone Perception: Multiple Receptor Families in Two Olfactory Systems

Hagino-Yamagishi, Kimiko

doi:10.2108/zsj.25.1179

Cited by 17 publications

(17 citation statements)

References 96 publications

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“…They are divided into Type 1 (V1R) and Type 2 (V2R) VRs. In rodents (such as mice and rats), both V1R and V2R are expressed, but only V1R is expressed in ruminants (such as cows and goats) and carnivorous (such as dogs and cats) [18,56,64]. In mice, the number of functional (intact) genes of OR, V1R, V2R and TAAR were 1037, 187, 121 and 15, respectively.…”

Section: Relationship Between the Vno And Pheromonesmentioning

confidence: 99%

“…V1R and V2R are coexpressed with G-protein subunits, G ai2 and G ao , respectively ( Fig. 2) and are considered to receive pheromone (and/or pheromone candidate) signals by promoting opening of an ion channel through inositol triphosphate (IP3) produced by phospholipase C [18].…”

Section: Relationship Between the Vno And Pheromonesmentioning

confidence: 99%

“…2A). V1R and V2R VSNs project into and terminate in the anterior and posterior parts of the GL of AOB, respectively [10,18,19,23] (Fig. 2A).…”

Section: Axon Projection Of Vnssmentioning

confidence: 99%

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Histological Properties of the Glomerular Layer in the Mouse Accessory Olfactory Bulb

Yokosuka

2012

Exp. Anim.

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Abstract:In mammals, the vomeronasal system (VS) originating from the vomeronasal organ (VNO; also called "Jacobson's organ") is considered to be a chemosensory system that recognizes "pheromone" signals. In the accessory olfactory bulb (AOB), the primary center of the VS, the glomerular cell layer (GL) of the AOB is regarded as an important functional area in the transmission of pheromone signals from vomeronasal sensory neurons (VSNs) of the VNO. In mice, the most frequently used animal model for the study of the VS, the GL of the AOB has several unique histological properties when compared with the main olfactory bulb (MOB): (i) each glomerular size is far smaller than in the MOB; (ii) many juxtaglomerular cells (JGCs) are GABA immunopositive, but subpopulations of cells distributed in the AOB are tyrosine hydroxylase-or calcium-binding protein immunopositive; and (iii) the dendritic branching pattern of the JGC in the AOB is heteromeric. The biological significance of the mammalian VS is still debated. The unique histological properties of the mouse AOB summerized in the present review may give some useful information that may help in understanding the function of the mammalian VS.

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Section: Relationship Between the Vno And Pheromonesmentioning

confidence: 99%

Section: Relationship Between the Vno And Pheromonesmentioning

confidence: 99%

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Histological Properties of the Glomerular Layer in the Mouse Accessory Olfactory Bulb

Yokosuka

2012

Exp. Anim.

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“…In contrast, Gα i2 -and Gα o -positive SNs in the VNO co-express the vomeronasal receptor type 1 (V1R) and the vomeronasal receptor type 2 (V2R), respectively, and detect chemical signals such as pheromones [4]. These vomeronasal SNs specifically project their axons to the accessory olfactory bulb (AOB) [4].…”

mentioning

confidence: 99%

Existence of Gα<i><sub>i2</sub></i>-Expressing Axon Terminals in the Goat Main Olfactory Bulb

Ohara

Okamura

Ichikawa

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. In rodents, Gα i2 -expressing sensory neurons (SNs) that co-express vomeronasal receptor type 1 (V1R) are specifically found in the vomeronasal organ (VNO) and project their axons to the accessory olfactory bulb (AOB). In goats, however, Gα i2 /V1R-expressing SNs exist in both the VNO and the olfactory epithelium. Thus, we examined whether the Gα i2 -expressing axons functionally project to the main olfactory bulb (MOB). We analyzed the expression of Gα i2 in the olfactory bulb and found small Gα i2 -immunoreactive clusters in the MOB. The Gα i2 -immunoreactive axons in these clusters made synaptic contacts with second-order neurons in the MOB. These results suggest that some Gα i2 -expressing SNs functionally project their axons to the MOB in goats. KEY WORDS: accessory olfactory bulb, Gα i2 , goat, main olfactory bulb, projection.

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“…In mammals, the vomeronasal receptors play a key role in pheromone detection action on gonadotropin-releasing hormone (GnRH)-secreting neurons to control some peripheral and central aspects of reproduction (Hagino-Yamagishi, 2008). Moreover, V2Rs are co-expressed with a family of MHC class I molecules for mate recognition in mice (Leinders-Zufall et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Reproduction, olfaction and dominance behaviour in Senegalese sole (Solea senegalensis)

Fernández¹

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Diverse Systems for Pheromone Perception: Multiple Receptor Families in Two Olfactory Systems

Cited by 17 publications

References 96 publications

Histological Properties of the Glomerular Layer in the Mouse Accessory Olfactory Bulb

Histological Properties of the Glomerular Layer in the Mouse Accessory Olfactory Bulb

Existence of Gα<i><sub>i2</sub></i>-Expressing Axon Terminals in the Goat Main Olfactory Bulb

Reproduction, olfaction and dominance behaviour in Senegalese sole (Solea senegalensis)

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