Diverse Polyphenols from Hypericum faberi

Zhang, Xin Wen; Ye, Yan Song; Xia, F.; Yang, Xing; Xu, Gang

doi:10.1007/s13659-019-0206-1

Cited by 4 publications

(2 citation statements)

References 26 publications

(17 reference statements)

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“…It is traditionally used to treat burns, wounds, bedsores, and myalgias due to the high content of valuable components with antibacterial, antiviral, anti-inflammatory, astringent, and restoring properties [ 21 , 24 ]. Plant species belonging to the genus Hypericum has been used since ancient times for the treatment of different diseases and, recently, scientific researchers focused their attention on the phytochemicals contained in these plants, confirming the high content in polyphenols [ 25 , 26 , 27 ]. In addition, the extract of H. scruglii disclosed excellent antioxidant activity and inhibitory effects on elastase.…”

Section: Introductionmentioning

confidence: 99%

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

et al. 2020

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An extract of Hypericum scruglii, an endangered endemic plant of Sardinia (Italy), was prepared and characterized. It was loaded in special phospholipid vesicles, glycerosomes, which were modified by adding maltodextrin (glucidex) and a polymer (gelatin or hyaluronan). The corresponding liposomes were also prepared and used as reference. The vesicles disclosed suitable physicochemical features for skin delivery. Indeed, their mean diameter ranged from 120 to 160 nm, they were homogeneously dispersed (polydispersity index ≤ 0.30), and their zeta potential was highly negative (~−45 mV). The vesicle dispersions maintained unchanged characteristics during 60 days of storage, were highly biocompatible, and were able to protect keratinocytes against damages due to oxidative stress induced by treating them with hydrogen peroxide. Vesicles were also capable of promoting cell proliferation and migration in vitro by means of a scratch wound assay. The results confirmed the fruitful delivery of the extract of H. scruglii in glycerosomes modified with glucidex and gelatin and their promising ability for skin protection and treatment.

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Section: Introductionmentioning

confidence: 99%

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

et al. 2020

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“…The following supporting information can be downloaded at: , Table S1: Biological activity of secondary metabolites identified in Hypericum genus plants [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ,…”

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confidence: 99%

Hypericum Genus as a Natural Source for Biologically Active Compounds

Caldeira

Gouveia

Serrano

et al. 2022

Plants

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Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression, wounds and burns, diarrhea, pain, fevers, and their secondary metabolites previously shown, and the in vitro and/or in vivo cytotoxic, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, and hepatoprotective activities, as well as the acetylcholinesterase and monoamine oxidase inhibitory activities. We conducted a systematic bibliographic search according to the Cochrane Collaboration guidelines to answer the question: “What is known about plants of Hypericum genus as a source of natural products with potential clinical biological activity?” We documented 414 different natural products with confirmed in vitro/in vivo biological activities, and 58 different Hypericum plant species as sources for these natural products. Phloroglucinols, acylphloroglucinols, xanthones, and benzophenones were the main chemical classes identified. The selective cytotoxicity against tumor cells, cell protection, anti-inflammatory, antimicrobial, antidepressant, anti-Alzheimer’s, and adipogenesis-inhibition biological activities are described. Acylphloroglucinols were the most frequent compounds with anticancer and cell-protection mechanisms. To date, no work has been published with a full descriptive list directly relating secondary metabolites to their species of origin, plant parts used, extraction methodologies, mechanisms of action, and biological activities.

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The Phytochemistry and Pharmacology of Hypericum

Xiao

Gibbons

2020

Progress in the Chemistry of Organic Natural Products 112

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Diverse Polyphenols from Hypericum faberi

Cited by 4 publications

References 26 publications

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

Hypericum Genus as a Natural Source for Biologically Active Compounds

The Phytochemistry and Pharmacology of Hypericum

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