The Phytochemistry and Pharmacology of Hypericum

Xiao, Chuan-Yun; Mu, Quanquan; Gibbons, Simon

doi:10.1007/978-3-030-52966-6_2

Cited by 12 publications

(13 citation statements)

References 197 publications

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“…In addition, it and other Hypericum plants have been used in traditional medicine as antimicrobials for external use—for example, for infected wounds [ 13 ]. This is related to the pronounced antimicrobial effect [ 14 ] mainly of their major secondary metabolites, the phloroglucinols, e.g., polycyclic polyprenylated acylphloroglucinols (PPAPs) such as hyperforin, the main antibacterial principle in H. perforatum [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. In some cases, naphtodianthrones (hypericins) also exert an antibacterial effect [ 5 , 23 , 24 ], as well as benzopyrans [ 25 ], xanthones [ 26 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Ilieva

Marinov

Trayanov

et al. 2023

Life

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Microbial infections are by no means a health problem from a past era due to the increasing antimicrobial resistance of infectious strains. Medicine is in constant need of new drugs and, recently, plant products have had a deserved renaissance and garnered scientific recognition. The aim of this work was to assess the antimicrobial activity of ten active ingredients from four Hypericum species growing in Bulgaria, as well as to obtain preliminary data on the phytochemical composition of the most promising samples. Extracts and fractions from H. rochelii Griseb. ex Schenk, H. hirsutum L., H. barbatum Jacq. and H. rumeliacum Boiss. obtained with conventional or supercritical CO2 extraction were tested on a panel of pathogenic microorganisms using broth microdilution, agar plates, dehydrogenase activity and biofilm assays. The panel of samples showed from weak to extraordinary antibacterial effects. Three of them (from H. rochelii and H. hirsutum) had minimum inhibitory concentrations as low as 0.625–78 mg/L and minimum bactericidal concentrations of 19.5–625 mg/L against Staphylococcus aureus and other Gram-positive bacteria. These values placed these samples among the best antibacterial extracts from the Hypericum genus. Some of the agents also demonstrated very high antibiofilm activity against methicillin-resistant S. aureus. Ultra-high-performance liquid chromatography–high-resolution mass spectrometry revealed the three most potent samples as rich sources of biologically active phloroglucinols. They were shown to be good drug or nutraceutical candidates, presumably without some of the side effects of conventional antibiotics.

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Section: Introductionmentioning

confidence: 99%

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Ilieva

Marinov

Trayanov

et al. 2023

Life

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Section: Phytochemical Compositionmentioning

confidence: 99%

“…Hypericum species contain a large number of secondary metabolites, including phloroglucinol derivatives, naphthodianthrones, xanthones, flavonoids and other phenolic elements, as well as terpenoids, which have been discovered so far in Hypericum species [13,3]. Currently, 768 phytochemicals have been identified from different Hypericum species Based on their biological functions, 160 of them have been documented for their biological activities [3]. In addition to terpenoids, spirolactone derivatives, and phenylpropanoid compounds (66), phytochemicals include derivatives of hyperforin (140), sampsoniones (93), Rottler-type compounds (40), spirocyclic phloroglucinols (25), simple benzophenones (82), simple phloroglucinol derivatives (131), xanthones (139), dianthrone compounds (11), and flavonoids (32) [14].…”

Section: Phytochemical Compositionmentioning

confidence: 99%

“…In addition, hypericin has been found to inhibit HIV by weakening the exterior of the virus. Likewise, hypericin is essential for the elimination of food contaminating bacteria such as Listeria and Salmonella species and has photodynamic activity [3]. The potential of H. perforatum formulations for the treatment of dermatological conditions of current interest is being investigated.…”

Section: Introductionmentioning

confidence: 99%

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Protective Role of Hypericum perforatum L. and Hypericum triquetrifolium Turra against Inflammatory Diseases: Evidence from In vitro and In vivo Studies

Kmail

2022

EJMP

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More than 500 species of Hypericum are located throughout Europe, North America, North Africa, and Asia. These plants have a long history of employment in folk medicine as anti-inflammatory, antibacterial, and antiviral medicines, as well as for the treatment of burns, gastrointestinal problems, and depression. The most significant species of this genus are Hypericum perforatum L. and Hypericum triquetrifolium Turra because of their pharmacological activities. Hypericum perforatum L. and Hypericum triquetrifolium are widely known for their efficacy in reducing inflammation and improving wound healing. The main reason these plants have been used for treatment of mild to moderate depression. Nevertheless, some similar species are also utilized in conventional medicine and have been previously analyzed for their biological activity and phytochemical composition. The main classes of active substances are found in Hypericum species, including naphthodianthrones (such as hypericin and pseudohyperricin), phloroglucinols (such as hyperforin), flavonoids (such as rutin, hyperoside, isoquercitrin, quercitrin, and amentoflavone), and phenylpropanoids (chlorogenic acid). This review's objective is to provide a summary of the most recent research on potential medicinal uses for Hypericum perforatum L., and Hypericum triquetrifolium Turra.

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“…Moreover, the species have been utilized as tea and dietary supplements (as an oil). The members of the genus Hypericum contain biologically active compounds, including hypericin, hyperforin and flavonoids [ 16 , 17 , 18 , 19 , 20 ]. Although many articles have been published on the biopharmaceutical properties of the Hypericum species [ 21 , 22 , 23 , 24 , 25 , 26 ], information on the chemical and biological properties is still lacking for most of them.…”

Section: Introductionmentioning

confidence: 99%

Novel Signposts on the Road from Natural Sources to Pharmaceutical Applications: A Combinative Approach between LC-DAD-MS and Offline LC-NMR for the Biochemical Characterization of Two Hypericum Species (H. montbretii and H. origanifolium)

Sut

Dall’Acqua

Zengin

et al. 2023

Plants

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The members of the genus Hypericum have great potential to develop functional uses in nutraceutical and pharmaceutical applications. With this in mind, we aimed to determine the chemical profiling and biological properties of different extracts (ethyl acetate, methanol and water) from two Hypericum species (H. montbretii and H. origanifolium). We combined two approaches (LC-DAD-MS and LC-NMR) to identify and quantify chemical compounds of the extracts. Antioxidant properties (free radical quenching, reducing power and metal chelating) and enzyme inhibitory effects (cholinesterase, tyrosinase, amylase and glucosidase) were determined as biological properties. The tested extracts were rich in caffeic acid derivatives and flavonoids, and among them, 3-caffeoyl quinic acid and myricetin-3-O-rhamnoside were found to be the main compounds. The total phenolic and flavonoid levels were determined to be 50.97–134.99 mg GAE/g and 9.87–82.63 mg RE/g, respectively. With the exception of metal chelating, the methanol and water extracts showed stronger antioxidant properties than the ethyl acetate extracts. However, different results were obtained for each enzyme inhibition assay, and in general, the ethyl acetate extracts present more enzyme-inhibiting properties than the water or methanol extracts. Results from chemical and biological analyses were combined using multivariate analysis, which allowed establishing relationships between composition and observed effects of the Hypericum extracts based on the extraction solvents. To gain more insights between chemical compounds and enzyme-inhibiting effects, we performed molecular docking analysis. We observed favorable interactions between certain compounds and the tested enzymes during our analysis, confirming the data obtained from the multivariate approach. In conclusion, the obtained results may shed light on the road from natural sources to functional applications, and the tested Hypericum species may be considered potential raw materials, with promising chemical constituents and biological activities.

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The Phytochemistry and Pharmacology of Hypericum

Cited by 12 publications

References 197 publications

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Protective Role of Hypericum perforatum L. and Hypericum triquetrifolium Turra against Inflammatory Diseases: Evidence from In vitro and In vivo Studies

Novel Signposts on the Road from Natural Sources to Pharmaceutical Applications: A Combinative Approach between LC-DAD-MS and Offline LC-NMR for the Biochemical Characterization of Two Hypericum Species (H. montbretii and H. origanifolium)

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