Diverse nanocomposites as a potential dressing for diabetic wound healing

Abstract

Wound healing is a programmed process of continuous events which is impaired in the case of diabetic patients. This impaired process of healing in diabetics leads to amputation, longer hospitalisation, immobilisation, low self-esteem, and mortality in some patients. This problem has paved the way for several innovative strategies like the use of nanotechnology for the treatment of wounds in diabetic patients. The use of biomaterials, nanomaterials have advanced approaches in tissue engineering by designing multi-functional nanocomposite scaffolds. Stimuli-responsive scaffolds that interact with the wound microenvironment and controlled release of bioactive molecules have helped in overcoming barriers in healing. The use of different types of nanocomposite scaffolds for faster healing of diabetic wounds is constantly being studied. Nanocomposites have helped in addressing specific issues with respect to healing and improving angiogenesis. Method: A literature search was followed to retrieve the articles on strategies for wound healing in diabetes across several databases like PubMed, EMBASE, Scopus and Cochrane database. The search was performed in May 2022 by two researchers independently. They keywords used were “diabetic wounds, nanotechnology, nanocomposites, nanoparticles, chronic diabetic wounds, diabetic foot ulcer, hydrogel”. Exclusion criteria included insulin resistance, burn wound, dressing material.

Melt electrowritten poly-lactic acid /nanodiamond scaffolds towards wound-healing patches

“…The majority of dressing materials reported before on wound healing were focused on modification of the materials and their function using biologically active molecules. Fewer studies combine the use of cells, bioactive molecules, and scaffolds [ 72 , 73 ]. We have successfully printed high-resolution PLA/ND scaffolds using MEW.…”

Novel ray of hope for diabetic wound healing: Hydrogen sulfide and its releasing agents

“…Nanomaterials have the advantages of controlled release, high efficiency, and low toxicity [18] , [63] . There are various substances conjugated with different anti-oxidative nanomaterials which are highly active in diabetic wound healing process [118] , [119] , [120] . For instance, cerium oxide nanoparticle (CNP) acts as a free radical scavenger conjugated with miR146a inhibiting the pro-inflammatory NF-κB pathway, which has a synergistic effect in regulating oxidative stress and inflammation, ultimately accelerating the healing process of diabetic wounds.…”

Wound Healing Effectiveness Test of Dermal Patch Formulated with Green Synthesized Silver Nanoparticles from Plantago major L. Extract

“…Other study found that a hydrocolloid film containing Vicenin-2, a natural compound with antioxidant and anti-inflammatory properties, can enhance diabetic wound healing in a dose-dependent manner (Tan et al, 2019). Sodium alginate, a natural polysaccharide with gel-forming properties, can also be used as a wound dressing to promote wound healing (Renuka et al, 2023). However, it's important to note that the effectiveness of topical preparations can vary depending on the type and severity of the wound, and it's always best to consult with a healthcare professional before using any new treatment.…”