Diverse functions of the auditory cortico-collicular pathway

Lesicko, Alexandria M.H.; Geffen, Maria N.

doi:10.1016/j.heares.2022.108488

Cited by 22 publications

(12 citation statements)

References 63 publications

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“…Tinnitus‐related changes in excitatory/inhibitory homeostasis are consistent with previously described tinnitus‐related plastic changes in central auditory neurotransmission (Auerbach et al., 2014; Noreña & Farley, 2013). Layer 5 PNs provide excitatory feedback to the MGB and extra‐lemniscal IC as well as local cortical circuits (Kommajosyula et al., 2021; Lesicko & Geffen, 2022; Williamson & Polley, 2019). Tinnitus‐related increases in layer 5 excitability theoretically could increase neuronal excitation at these target structures, potentially initiating reciprocal extra‐lemniscal feed‐forward excitation to A1 (Blackwell et al., 2020; Stebbings et al., 2014; Syka & Popelář, 1984; Williamson & Polley, 2019).…”

Section: Discussionmentioning

confidence: 99%

Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour

Ghimire

Cai

Ling

et al. 2023

The Journal of Physiology

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Section: Discussionmentioning

confidence: 99%

Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour

Ghimire

Cai

Ling

et al. 2023

The Journal of Physiology

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Section: Discussionmentioning

confidence: 99%

“…Together, this indicates the FFR is not merely a passive representation of the acoustic speech signal but is dynamically shaped by higher-order perceptual processes, and by surrounding stimulus context. Such active modulation of brainstem representations might help simplify speech decisions upon arrival to auditory cortex (Asilador and Llano, 2021;Lesicko and Geffen, 2022). Importantly, our speech stimuli were designed with F0s well above cortical phase locking limits as reported in both humans and animal models (Brugge et al, 2009;Gnanateja et al, 2021;Guo et al, 2021;Joris et al, 2004;Wallace et al, 2000).…”

Section: Brainstem Ffrs Carry Category-level Information (Perceptual ...mentioning

confidence: 99%

Perceptual warping exposes categorical representations for speech in human brainstem responses

Carter

Bidelman

2022

Preprint

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The brain transforms continuous acoustic events into discrete category representations to downsample the speech signal for our perceptual-cognitive systems. Such phonetic categories are highly malleable and heir percepts can change depending on surrounding stimulus context. Previous work suggests these acoustic-phonetic mapping and perceptual warping of speech emerge in the brain no earlier than auditory cortex. Here, we examined whether these auditory-category phenomena inherent to speech perception occur even earlier in the human brain, at the level of auditory brainstem. We recorded speech-evoked frequency following responses (FFRs) during a task designed to induce more/less warping of listeners' perceptual categories depending on stimulus presentation order of a speech continuum (random, forward, backward directions). We used a novel clustered stimulus paradigm to rapidly record the high trial counts needed for FFRs concurrent with active behavioral tasks. We found serial stimulus order caused perceptual shifts (hysteresis) near listeners' category boundary confirming identical speech tokens are perceived differentially depending on stimulus context. Critically, we further show neural FFRs during active (but not passive) listening are enhanced for prototypical vs. category-ambiguous tokens and are biased in the direction of listeners' phonetic label even for acoustically-identical speech stimuli. Our data expose FFRs carry category-level information and suggest top-down processing actively shapes the neural encoding and categorization of speech at subcortical levels. These findings suggest the acoustic-phonetic mapping and perceptual warping in speech perception occur surprisingly early along the auditory neuroaxis, which might aid understanding by reducing ambiguity inherent to the speech signal.

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“…Tinnitus-related changes in excitatory/inhibitory homeostasis are consistent with previously described tinnitus-related plastic changes in central auditory neurotransmission (Noreña & Farley, 2013; Auerbach et al ., 2014). Layer 5 PNs provide excitatory feedback to the MGB and extra-lemniscal IC as well as local cortical circuits (Williamson & Polley, 2019; Kommajosyula et al ., 2021; Lesicko & Geffen, 2022). Tinnitus-related increases in layer 5 excitability theoretically could increase neuronal excitation at these target structures, potentially initiating reciprocal extra-lemniscal feed-forward excitation to A1 (Syka & Popelář, 1984; Stebbings et al ., 2014; Williamson & Polley, 2019; Blackwell et al ., 2020).…”

Section: Discussionmentioning

confidence: 99%

Increased Pyramidal and VIP Neuronal Excitability in Primary Auditory Cortex Directly Correlates with Tinnitus Behavior

Ghimire

Cai

Ling

et al. 2022

Preprint

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Tinnitus affects roughly 15-20% of the population while severely impacting 10% of those afflicted. Tinnitus pathology is multifactorial, generally initiated by damage to the auditory periphery, resulting in a cascade of maladaptive plastic changes at multiple levels of the central auditory neuraxis as well as limbic and non-auditory cortical centers. Using a well-established condition-suppression model of tinnitus, we measured tinnitus-related changes in the microcircuits of excitatory/inhibitory neurons onto layer 5 pyramidal neurons (PNs), as well as changes in the excitability of vasoactive intestinal peptide (VIP) neurons in primary auditory cortex (A1). Patch-clamp recordings from PNs in A1 slices showed tinnitus-related increases in spontaneous excitatory postsynaptic currents (sEPSCs) and decreases in spontaneous inhibitory postsynaptic currents (sIPSCs). Both measures were directly correlated to the rat's behavioral evidence of tinnitus. Tinnitus-related changes in PN excitability were independent of changes in A1 excitatory or inhibitory cell numbers. VIP neurons, part of an A1 local circuit that can disinhibit layer 5 PNs, showed significant tinnitus-related increases in excitability that directly correlated with the rat's behavioral tinnitus score. That PN and VIP changes directly correlated to tinnitus behavior, suggests an essential role in A1 tinnitus pathology. Tinnitus-related A1 changes were similar to findings in studies of neuropathic pain in somatosensory cortex suggesting a common pathology of these troublesome perceptual impairments. Improved understanding between excitatory, inhibitory and disinhibitory sensory cortical circuits can serve as a model for testing therapeutic approaches to the treatment of tinnitus and chronic pain.

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Diverse functions of the auditory cortico-collicular pathway

Cited by 22 publications

References 63 publications

Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour

Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour

Perceptual warping exposes categorical representations for speech in human brainstem responses

Increased Pyramidal and VIP Neuronal Excitability in Primary Auditory Cortex Directly Correlates with Tinnitus Behavior

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