Diverse Functions of N-Cadherin in Dendritic and Axonal Terminal Arborization of Olfactory Projection Neurons

Zhu, Haitao; Luo, Liqun

doi:10.1016/s0896-6273(04)00142-4

Cited by 132 publications

(121 citation statements)

References 38 publications

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“…These findings indicate that besides axial information, discrete determinants also provide positional information to the PN dendrites. Moreover, the cell adhesion molecule N-cadherin (Ncad) and immunoglobulin superfamily protein Dscam act as attractive or repulsive signals in most of the PN classes that restrict the dendritic field to the appropriate glomerular space (Zhu and Luo 2004;Zhu et al 2006). In addition to these findings, we here found that the dendritic boundary formation between specific subtypes of PNs are instructed by cell surface molecules, Eph, and Ephrin.…”

supporting

confidence: 54%

Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila

Anzo¹,

Sekine²,

Makihara³

et al. 2017

Genes Dev.

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Proper function of the neural network results from the precise connections between axons and dendrites of presynaptic and postsynaptic neurons, respectively. In the Drosophila olfactory system, the dendrites of projection neurons (PNs) stereotypically target one of ∼50 glomeruli in the antennal lobe (AL), the primary olfactory center in the brain, and form synapses with the axons of olfactory receptor neurons (ORNs). Here, we show that Eph and Ephrin, the well-known axon guidance molecules, instruct the dendrodendritic segregation during the discrete olfactory map formation. The Eph receptor tyrosine kinase is highly expressed and localized in the glomeruli related to reproductive behavior in the developing AL. In one of the pheromone-sensing glomeruli (DA1), the Eph cell-autonomously regulates its dendrites to reside in a single glomerulus by interacting with Ephrins expressed in adjacent PN dendrites. Our data demonstrate that the trans interaction between dendritic Eph and Ephrin is essential for the PN dendritic boundary formation in the DA1 olfactory circuit, potentially enabling strict segregation of odor detection between pheromones and the other odors.

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supporting

confidence: 54%

Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila

Anzo¹,

Sekine²,

Makihara³

et al. 2017

Genes Dev.

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“…The classification works on a purely statistical basis. In recent work in Drosophila [29,23,55,44] the specificity of PN projections to the MB and the protocerebrum has been investigated. Marin et al [29], e.g., state: "inspection of axon collateral projections of different classes of PNs did not reveal obvious stereotype as compared to the striking stereotype of lateral horn axon branching pattern and terminal fields ."…”

Section: Discussionmentioning

confidence: 99%

Self-organization in the olfactory system: one shot odor recognition in insects

Nowotny¹,

Huerta²,

Abarbanel

et al. 2005

Biol Cybern

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Mikhail I (2005) Selforganization in the olfactory system: one shot odor recognition in insects. Biological Cybernetics, 93 (6). pp. 436-446. ISSN 1432-0770 This version is available from Sussex Research Online: http://sro.sussex.ac.uk/1552/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. The date of receipt and acceptance will be inserted by the editorAbstract We show in a model of spiking neurons that synaptic plasticity in the mushroom bodies in combination with the general fan-in, fan-out properties of the early processing layers of the olfactory system might be sufficient to account for its efficient recognition of odors.For a large variety of initial conditions the model system consistently finds a working solution without any finetuning, and is, therefore, inherently robust. We demonstrate that gain control through the known feedforward inhibition of lateral horn interneurons increases the capacity of the system but is not essential for its general function. We also predict an upper limit for the number of odor classes Drosophila can discriminate based on the number and connectivity of its olfactory neurons.

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“…Loss of Ncad causes dendrites to spread beyond the developing antennal lobe or invade neighboring glomeruli (Zhu and Luo 2004). This phenotype was observed at an early developmental stage, suggesting that Ncad functions in initial confinement of dendrites to the appropriate glomerular space.…”

Section: Pn Dendrite Targetingmentioning

confidence: 98%

“…This suggests that Dscam functions in PN dendrites to expand and occupy the local space, while also preventing them from collapsing onto each other. Both Dscam and Ncad do not appear to play instructive roles for class-specific targeting, as they equally affect all PN classes examined (Zhu and Luo 2004;Zhu et al 2006a). …”

Section: Pn Dendrite Targetingmentioning

confidence: 99%

Genetic Control of Wiring Specificity in the Fly Olfactory System

Hong

Luo

2014

Genetics

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Precise connections established between pre-and postsynaptic partners during development are essential for the proper function of the nervous system. The olfactory system detects a wide variety of odorants and processes the information in a precisely connected neural circuit. A common feature of the olfactory systems from insects to mammals is that the olfactory receptor neurons (ORNs) expressing the same odorant receptor make one-to-one connections with a single class of second-order olfactory projection neurons (PNs). This represents one of the most striking examples of targeting specificity in developmental neurobiology. Recent studies have uncovered central roles of transmembrane and secreted proteins in organizing this one-to-one connection specificity in the olfactory system. Here, we review recent advances in the understanding of how this wiring specificity is genetically controlled and focus on the mechanisms by which transmembrane and secreted proteins regulate different stages of the Drosophila olfactory circuit assembly in a coordinated manner. We also discuss how combinatorial coding, redundancy, and error-correcting ability could contribute to constructing a complex neural circuit in general.

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Diverse Functions of N-Cadherin in Dendritic and Axonal Terminal Arborization of Olfactory Projection Neurons

Cited by 132 publications

References 38 publications

Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila

Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila

Self-organization in the olfactory system: one shot odor recognition in insects

Genetic Control of Wiring Specificity in the Fly Olfactory System

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