Diverse Effects of Noradrenaline and Adrenaline on the Quantal Secretion of Acetylcholine at the Mouse Neuromuscular Junction

Tsentsevitsky, A. N.; Kovyazina, I. V.; Bukharaeva, É. A.

doi:10.1016/j.neuroscience.2019.10.049

Cited by 18 publications

(8 citation statements)

References 67 publications

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“…Previously, we observed the same effects for adrenaline and noradrenaline. The noradrenaline effect was prevented by the β-adrenoceptor blocker propranolol, whereas the adrenaline action was prevented by the α-adrenoceptor antagonist phentolamine [ 30 , 31 ]. The action of specific α1- and α2-adrenoceptor agonists was eliminated by blockers of α1-receptors doxazosin and α2-receptors SKF86466.…”

Section: Activators and Blockers Of Adrenergic Receptors Alter The Spontaneous Achmentioning

confidence: 99%

“…In contrast, procaterol, a β2-adrenoceptor agonist, slightly but significantly increased the EPP quantal content [ 30 ]. The oppositely directed action of the different types of adrenergic receptors activators may cause no effect of noradrenaline on the EPP quantal content [ 28 , 31 ].…”

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

“…However, at the mouse diaphragm NMJ, the opposite desynchronization effect of noradrenaline was observed, and both α- and β-receptors were involved in this action [ 31 ]. In contrast to the observations at frog and soleus muscle NMJ, data obtained demonstrate that the activation of α2-adrenoceptors by dexmedetomidine and β2-adrenoceptors by procaterol increased the ACh quantal secretion asynchrony at mouse diaphragm.…”

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

“…In contrast to the observations at frog and soleus muscle NMJ, data obtained demonstrate that the activation of α2-adrenoceptors by dexmedetomidine and β2-adrenoceptors by procaterol increased the ACh quantal secretion asynchrony at mouse diaphragm. These effects were eliminated by α2- and β2-adrenoceptor blockers [ 30 , 31 ].…”

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

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Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Bukharaeva

Khuzakhmetova

Dmitrieva

et al. 2021

IJMS

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Adrenoceptor activators and blockers are widely used clinically for the treatment of cardiovascular and pulmonary disorders. More recently, adrenergic agents have also been used to treat neurodegenerative diseases. Recent studies indicate a location of sympathetic varicosities in close proximity to neuromuscular junctions. The pressing question is whether there could be any effects of endo- or exogenous catecholamines on cholinergic neuromuscular transmission. It was shown that the pharmacological stimulation of adrenoceptors, as well as sympathectomy, can affect both acetylcholine release from motor nerve terminals and the functioning of postsynaptic acetylcholine receptors. In this review, we discuss the recent data regarding the effects of adrenergic drugs on neurotransmission at the neuromuscular junction. The elucidation of the molecular mechanisms by which the clinically relevant adrenomimetics and adrenoblockers regulate quantal acetylcholine release from the presynaptic nerve terminals and postsynaptic sensitivity may help in the design of highly effective and well-tolerated sympathomimetics for treating a number of neurodegenerative diseases accompanied by synaptic defects.

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Section: Activators and Blockers Of Adrenergic Receptors Alter The Spontaneous Achmentioning

confidence: 99%

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

See 2 more Smart Citations

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Bukharaeva

Khuzakhmetova

Dmitrieva

et al. 2021

IJMS

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“…A norepinefrina e epinefrina liberadas durante a atividade física têm efeitos cardiovasculares, neurológicos, musculares e metabólicos importantes para o exercício físico. A descarga adrenérgica autonômica age diminuindo o limiar de excitação do sistema musculoesquelético pela acetilcolina e aumentando sua liberação na fenda sináptica (Tsentsevitsky et al, 2019), (Michelini et al, 2015), (Rodrigues et al, 2019). Essa descarga também causa uma constrição nas arteríolas e artérias do sistema cutâneo, mucoso, visceral e nas veias através dos receptores alfa-adrenérgicos, e causam uma vasodilatação mediada por receptores adrenérgicos beta2 nas artérias e arteríolas cerebrais, musculares e coronárias, desviando o fluxo sanguíneo que pode aumentar em até 50 vezes no músculo.…”

Section: Atividade Físicaunclassified

Influência da atividade física na indução da autofagia e redução da incidência do câncer: revisão crítica dos mecanismos fisiológicos e metabólicos.

Botelho

César

Teixeira

2021

RSD

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Objetivo: Descrever os principais mecanismos da autofagia estimulada por atividade física e sua relação com a redução na incidência de câncer. Material e métodos: Foram realizadas coletas de dados através da análise da literatura científica disponível nas bases de dados da MEDLINE, ScienceDirect e Wiley, de maneira independente e manual. Foram utilizados como descritores de busca os termos: “cancer”, “autophagy” e “physical activity”, e o período de tempo para as publicações compreendeu os anos de 1990 a 2020. O critério de inclusão foi: “trabalhos publicados dentro do escopo do estudo, publicados no intervalo de tempo citado”. E como critério de exclusão: “trabalhos não relacionados ao tema de estudo e com relatos já ultrapassados de acordo com a literatura atual”. Resultados: A atividade física influência positivamente diversos sistemas, levando a alterações agudas e crônicas. Os benefícios em patologias metabólicas, imunes, cancerígenas, cardiovasculares, psiquiátricas e neurológicas são indiscutíveis e os mecanismos estão sendo elucidados. Autofagia medeia a digestão e reciclagem de partes obsoletas da célula durante a inanição e participa de uma variedade de processos fisiológicos de remoção residual. A autofagia é capaz de eliminar as microorganimos, agregados proteicos tóxicos, genotóxicos, desempenhando papéis durante a infecção, envelhecimento e patogênese de doenças. Conclusão: A partir da análise dos mecanismos envolvidos na autofagia induzida por atividade física ficaram postulados três pontos principais: 1) Via mTORC1 inativada por inanição, 2) Regulação por espécies reativas de oxigênio e hipóxia, 3) Regulação da autofagia por vias alternativas à mTORC1.

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Studies on the mechanism of energy metabolism via AMPK/PGC‐1α signaling pathway induced by compatibility of Ligusticum chuanxiong Hort and Gastrodia

Yang

Lin

et al. 2022

Phytotherapy Research

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AMP‐activated protein kinase (AMPK) regulates overall energy consumption and energy intake through cytokines. Ligusticum striatum DC (CX) combined with Gastrodia elata Blume (TM) has been used for migraine treatment for millennia. When used alone in clinical practice, CX causes symptoms of thirst, irritability, and yellow urine and has influenced the levels of cytokines such as AMP that activate the AMPK pathway of energy metabolism. However, relationships between this compatibility prescription, integral biological energy metabolism, and the AMPK pathway remain unclear. Studies were performed by treating normal rats with physiological saline, CX extract, CX coupled TM extract, and TM extracts separately for 4 weeks. Food intake, water intake, urine output, stool output, and body weight were monitored once a week by the metabolic cage method. Values of FBG, BUN, TP, TC and TG in blood samples were detected approaching the whole blood automatic detector from 1 to 4 weeks. Na+‐K+‐ATPase, Ca2+‐Mg2+‐ATPase, cAMP, and cGMP activity were determined by the enzyme‐linked immunosorbent assay (ELISA); the biological samples that were obtained at 1, 2, 3, and 4 weeks after drug administration were tested by GC‐TOF‐MS. Then real‐time PCR and Western Blot were applied to detect changes in expression of some substances involved in energy metabolism. The results demonstrated that administering CX alone increased energy input, mobility, and respiratory exchange ratio, accelerated energy consumption, and caused inflammatory infiltration in the liver. CX coupled with TM led to lower energy metabolism and liver damage in comparison with CX used alone. Moreover, CX‐treated rats harbored higher levels of differential metabolites (including pyrophosphate, oxaloacetic acid, and galactinol). Glycerophospholipid metabolism and the citrate cycle are closely related to the differential metabolites above. In addition, CX‐induced unbalanced energy metabolism depends on cAMP activation mediated by the AMPK/PGC‐1α pathway in rats. Our findings suggest that CX‐induced energy metabolism imbalance was corrected after coupling with TM by mediating the AMPK/PGC‐1α pathway.

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Diverse Effects of Noradrenaline and Adrenaline on the Quantal Secretion of Acetylcholine at the Mouse Neuromuscular Junction

Cited by 18 publications

References 67 publications

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Influência da atividade física na indução da autofagia e redução da incidência do câncer: revisão crítica dos mecanismos fisiológicos e metabólicos.

Studies on the mechanism of energy metabolism via AMPK/PGC‐1α signaling pathway induced by compatibility of Ligusticum chuanxiong Hort and Gastrodia

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