Diverse Effects of FK506 on the Apoptosis of Hepatocytes and Infiltrating Lymphocytes in an Allografted Rat Liver

Abstract

Background. The current study investigated whether FK506 (FK) regulates the

Roles of the tacrolimus-dependent transcription factor IRF4 in acute rejection after liver transplantation

“…TAC functions largely by repressing T cell cytokine gene transcription. TAC also enhances the apoptosis of activated T cells in vivo [28]. Consistent with previous studies, our results showed that TAC suppressed acute rejection after LTx and improved survival time, histopathological changes and blood chemistry data.…”

“…NFAT could bind the promoter of IL-2 in activated T cells as a nuclear factor [28]. The mechanism of NFAT activation was discovered indirectly during researches of the mechanism of the immunosuppressive drug cyclosporine.…”

Recurrent hepatitis C virus infection post liver transplantation: impact of choice of calcineurin inhibitor

“…CsA has demonstrated anti‐apoptotic activity in vitro and in vivo , and reports have suggested that CsA may protect against Fas‐mediated apoptosis in vivo . While initial in vitro evidence suggested tacrolimus did not have an anti‐apoptotic effect , more recent data suggest it may be anti‐apoptotic , indicating the need for further study to investigate whether the potential anti‐apoptotic effects of CsA represent a viable hypothesis for the differences in fibrosis outcomes in patients receiving CsA or tacrolimus.…”