Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model

Deng, Lulu; Ou, Zihao; Huang, Dongquan; Li, Chong; Lu, Ziwen; Liu, Wanting; Wu, Feng; Nong, Caihong; Gao, Jie; Peng, Yongzheng

doi:10.1016/j.micpath.2020.104353

Cited by 39 publications

(55 citation statements)

References 45 publications

(56 reference statements)

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“…A. muciniphila, the next-generation beneficial microbes, is severely reduced in several pathological conditions (such as obesity, type 2 diabetes, inflammatory bowel diseases, and appendicitis) 38,39,40 Either direct oral administration of A. muciniphila or enrichment of the abundance of A. muciniphila in vivo through dietary or pharmacologic interventions has been proved to be a practicable therapeutic strategy for metabolic disorders including amelioration in body weight and fat mass, improvement in insulin-resistance and liver fat accumulation. 16,17,19 A latest study revealed that A. muciniphila was decreased in patients with alcoholic liver disease (ALD) and recovery of A. muciniphila in ALD mice protects against hepatic steatosis and injury.…”

Section: Discussionmentioning

confidence: 99%

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

et al. 2021

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The gut bacterium Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunctionassociated fatty liver disease (MAFLD). However, its underlying mechanism involved in its wellknown metabolic actions needs further evaluation. The present study explored the therapeutic effect and mechanism of A. muciniphila in intervening MAFLD by using a high-fat and highcholesterol (HFC) diet induced obese mice model. Mice treated with A. muciniphila efficiently reversed MAFLD in the liver, such as hepatic steatosis, inflammatory, and liver injury. These therapeutic effects persisted after long-term drug withdrawal and were slightly weakened in the antibiotics-treated obese mice. A. muciniphila treatment efficiently increased mitochondrial oxidation and bile acid metabolism in the gut-liver axis, ameliorated oxidative stress-induced cell apoptosis in gut, leading to the reshaping of the gut microbiota composition. These metabolic improvements occurred with increased L-aspartate levels in the liver that transported from the gut. The administration of L-aspartate in vitro or in mice displayed the similar beneficial metabolic effects mentioned above and efficiently ameliorated MAFLD. Together, these data indicate that the anti-MAFLD activity of A. muciniphila correlated with lipid oxidation and improved gut-liver interactions through regulating the metabolism of L-aspartate. A. muciniphila could be a potential agent for clinical intervention in MAFLD.

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Section: Discussionmentioning

confidence: 99%

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

et al. 2021

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“…Contradictory, Kim et al [37] and Deng et al [38] reported that no difference in weight gain was observed between groups treated and not non-treated group with A. muciniphila. Deng et al [38] showed that the size of adipocytes in inguinal white adipose tissue (iWAT) and epididymal white adipose tissue (eWAT) was significantly increased by HFD. However, treatment with cells of strains GP01 and GP25 alleviate the effect.…”

Section: A Muciniphila In the Improvement Of Obesity Parametersmentioning

confidence: 97%

“…According to Deng et al [38], A. muciniphila treatment reduced fasting blood glucose levels in HFD mice as compared to the HFD group. OGTT tests revealed that A. muciniphila intervention significantly enhanced HFD mice's impaired glucose tolerance.…”

Section: A Muciniphila In the Improvement Of Insulin Sensitivity And Glucose Homeostasismentioning

confidence: 99%

“…Finally, after the application of inclusion and exclusion criteria, only 10 studies were considered as the main source for testing the theory of A. muciniphila and its association with obesity (Figure 1). After assessing the quality of the selected studies by the Modified Downs and Black checklist, 3 studies [29][30][31] showed excellent quality, and 7 studies [32][33][34][35][36][37][38] were good quality.…”

Section: Selection Of Studiesmentioning

confidence: 99%

“…Ten studies have investigated the effect of A. muciniphila supplementation on the vital obesity parameters and metabolic disorder in C57BL/6J mice models [29][30][31][32][33][34][35][36][37][38]. In 2020, Yang et al [29] found that the body weight gain, caloric intake, mesenteric fat weight, subcutaneous fat weight, epididymal fat weight, total fat and energy efficiency significantly decreased in high fat diet (HFD)-fed mice after treatment with pasteurized culture of A. muciniphila.…”

Section: A Muciniphila In the Improvement Of Obesity Parametersmentioning

confidence: 99%

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Akkermansia muciniphila, a New Generation of Beneficial Microbiota in Modulating Obesity: A Systematic Review

2021

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Obesity is a complex syndrome and is recognized as the ultimate pathway of many chronic diseases. Studies using Akkermansia muciniphila supplementation strategy have proved to be effective for the prevention and treatment of obesity and other metabolic disorders. Although there are studies that support the protective effect of this strategy, the effects on the prevention of obesity on humans are not clear yet and need more investigation. The aim of this study is to investigate the effect of A. muciniphila administration on modulating obesity. This systematic review was generated from articles published within the last 10 years. All articles were in English and included animal subjects. The review relied on the search engines Google Scholar, Pub Med, Web of Science and Medline using the following keywords: A. muciniphila, next-generation probiotic, new-generation probiotic, obesity, fat mass, body fat and lipid profile. The search has revealed 804 articles with relevant key words. After the exclusion of irrelevant articles, 10 studies were selected based on the criteria. These studies were randomized controlled trials that have shown that A. muciniphila modulates obesity by regulating metabolism and energy hemostasis and improving insulin sensitivity and glucose hemostasis. In addition, studies showed this microorganism enhances low grade inflammation by different mechanisms.

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Flavonoids, gut microbiota, and host lipid metabolism

Zhou,

Ma,

Kang

et al. 2023

Engineering in Life Sciences

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Flavonoids are widely distributed in nature and have a variety of beneficial biological effects, including antioxidant, anti‐inflammatory, and anti‐obesity effects. All of these are related to gut microbiota, and flavonoids also serve as a bridge between the host and gut microbiota. Flavonoids are commonly used to modify the composition of the gut microbiota by promoting or inhibiting specific microbial species within the gut, as well as modifying their metabolites. In turn, the gut microbiota extensively metabolizes flavonoids. Hence, this reciprocal relationship between flavonoids and the gut microbiota may play a crucial role in maintaining the balance and functionality of the metabolism system. In this review, we mainly highlighted the biological effects of antioxidant, anti‐inflammatory and antiobesity, and discussed the interaction between flavonoids, gut microbiota and lipid metabolism, and elaborated the potential mechanisms on host lipid metabolism.

show abstract

Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model

Cited by 39 publications

References 45 publications

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Akkermansia muciniphila, a New Generation of Beneficial Microbiota in Modulating Obesity: A Systematic Review

Flavonoids, gut microbiota, and host lipid metabolism

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