2015
DOI: 10.1002/cne.23713
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Divergent innervation of the olfactory bulb by distinct raphe nuclei

Abstract: The raphe nuclei provide serotonergic innervation widely in the brain, thought to mediate a variety of neuromodulatory effects. The mammalian olfactory bulb (OB) is a prominent recipient of serotonergic fibers, particularly in the glomerular layer (GL), where they are thought to gate incoming signals from the olfactory nerve. The dorsal raphe nucleus (DRN) and the median raphe nucleus (MRN) are known to densely innervate the OB. The majority of such projections are thought to terminate in the GL, but this has … Show more

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Cited by 38 publications
(34 citation statements)
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“…2 D ). Particularly in the olfactory bulb, the massive amounts of anti–5-HT fibers originating in the MRN and terminating in the glomerular layer (McLean and Shipley, 1987; Steinfeld et al, 2015; Suzuki et al, 2015; Muzerelle et al, 2016), the first synaptic processing layer of odor information, were absent in AAV-Cre–injected Tph2 fl/fl mice (Fig. 2 D ).…”
Section: Resultsmentioning
confidence: 99%
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“…2 D ). Particularly in the olfactory bulb, the massive amounts of anti–5-HT fibers originating in the MRN and terminating in the glomerular layer (McLean and Shipley, 1987; Steinfeld et al, 2015; Suzuki et al, 2015; Muzerelle et al, 2016), the first synaptic processing layer of odor information, were absent in AAV-Cre–injected Tph2 fl/fl mice (Fig. 2 D ).…”
Section: Resultsmentioning
confidence: 99%
“…2 A ). In adult Tph2 fl/fl mice, AAV-Cre or AAV-GFP was injected into the midbrain, where 5-HT neurons of the MRN/DRN are located and project to olfactory structures in the forebrain (McLean and Shipley, 1987; Steinfeld et al, 2015). …”
Section: Resultsmentioning
confidence: 99%
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“…The olfactory bulb (OB) receives dense serotonergic innervation, particularly from the median raphe to the glomerular layer (McLean and Shipley 1987;Steinfeld et al 2015), but relatively little is known about 5HT modulation of glomerular circuits. Glomeruli are the first site of synaptic processing for odorant signals from the olfactory epithelium.…”
mentioning
confidence: 99%
“…In comparison to other sensory regions at a similar level of the hierarchy, the OB receives massive feedback projections from cortical, subcortical [38][39][40][41][42][43][44][45][46] and neuromodulatory centres [47][48][49]. These regions may convey back to the OB information that is not primarily sensory.…”
Section: Flexible Categorisation Following Learningmentioning
confidence: 99%