Divergent effects of distinct perivascular cell subsets for intra‐articular cell therapy in posttraumatic osteoarthritis

Hsu, Ginny Ching Yun; Cherief, Masnsen; Sono, Takashi; Wang, Yiyun; Negri, Stefano; Xu, Jiajia; Péault, Bruno; James, Aaron W.

doi:10.1002/jor.24997

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…Seventeen studies evaluated the effects by imaging analysis: nine studies (52.9%) reported significant differences in favour of adipose-derived products, while eight studies observed no differences. In particular, micro-computed tomography (micro-CT) evaluation was performed in six studies, with positive effects in five studies in terms of prevention of cartilage and subchondral bone degeneration and improvement of bone thickness and volume [23][24][25][26][27]. Radiographic evaluation was performed in 6 studies with only one study showing a statistically significant difference in favour of adipose-derived products [28].…”

Section: Imaging Analysismentioning

confidence: 99%

Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies

Orfei

Boffa

Sourugeon

et al. 2022

Knee Surg Sports Traumatol Arthrosc

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Purpose The aim of this systematic review was to determine if adipose tissue-derived cell-based injectable therapies can induce disease-modifying effects in joints affected by osteoarthritis (OA). Methods A systematic review was performed on three electronic databases (PubMed, Web of Science, Embase) according to PRISMA guidelines. A synthesis of the results was performed investigating disease-modifying effects in preclinical studies comparing injectable adipose-derived products with OA controls or other products, different formulations or injection intervals, and the combination with other products. The risk of bias was assessed according to the SYRCLE’s tool. Results Seventy-one studies were included (2,086 animals) with an increasing publication trend over time. Expanded cells were used in 65 studies, 3 studies applied point of care products, and 3 studies investigated both approaches. Overall, 48 out of 51 studies (94%) reported better results with adipose-derived products compared to OA controls, with positive findings in 17 out of 20 studies (85%) in macroscopic, in 37 out of 40 studies (93%) in histological, and in 22 out of 23 studies (96%) in immunohistochemical evaluations. Clinical and biomarker evaluations showed positive results in 14 studies out of 18 (78%) and 12 studies out of 14 (86%), while only 9 studies out of 17 (53%) of the imaging evaluations were able to detect differences versus controls. The risk of bias was low in 38% of items, unclear in 51%, and high in (11%). Conclusion The current preclinical models document consistent evidence of disease-modifying effects of adipose-derived cell-based therapies for the treatment of OA. The high heterogeneity of the published studies highlights the need for further targeted research to provide recommendations on the optimal methodologies for a more effective application of these injective therapies for the treatment of OA in clinical practice. Level of evidence II. Graphical Abstract

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Section: Imaging Analysismentioning

confidence: 99%

Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies

Orfei

Boffa

Sourugeon

et al. 2022

Knee Surg Sports Traumatol Arthrosc

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“…OARSI grading ranged from G1 to G6. OARSI score was calculated according to the formula: score = grade (G1 to G6) × stage (S1 to S4) 20,21 . OARSI score ranged from 0-24. was determined according to the formula: score = grade (G1 to G6) × stage (S1 to S4) 20,21 .…”

Section: Discussionmentioning

confidence: 99%

“…OARSI grading ranged from G1 to G6. OARSI score was calculated according to the formula: score□=□grade (G1 to G6)□×□stage (S1 to S4) 20,21 . OARSI score ranged from 0–24.…”

Section: Methodsmentioning

confidence: 99%

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A Novel Burn / Synovectomy Mouse Model for Temporomandibular Joint Osteoarthritis

Hsu

2023

Preprint

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Temporomandibular Disorders (TMDs) is present in 33% of the U.S. population. Currently available animal models do not faithfully simulate the native disease progression of TMJ OA. The initiation of TMJ OA requires both local trauma and systemic inflammation. In this study, we present a novel mouse model which reproduces these two conditions. This is achieved by a procedure involving both synovectomy (local trauma) and a distant burn injury (systemic inflammation). Its efficacy at inducing TMJ OA was assessed with histomorphology and radiographic evaluation at 1,3, and 9 weeks after the procedure. We found that burn/synovectomy mice demonstrated significantly more degenerative changes in TMJ than uninjured control mice or synovotomy mice. The observed histology in burn/synoectomy mice mimicked native TMJ OA disease progression in a faithful manner. This animal model is invaluable in future research of the mechanism and risk factors of TMJ OA.

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“…In addition to the bone loss and fracture risk associated with cancer therapy; in bone marrow transplantations, metastatic bone disease, and cancer settings, the re-establishment of bone marrow microenvironments after chemotherapy and radiation is crucial for the effective treatment outcome and clinical management of these conditions (Chen et al, 2012; D’Oronzo et al, 2019; Singh et al, 2019; Tsukamoto et al, 2021; Vi et al, 2018; Wu et al, 2018). The bone vasculature and perivascular mesenchymal stem cells, which can differentiate to generate bone cells, adipocytes and chondrocytes, are essential for bone growth, and hematopoietic stem cell (HSC) maintenance (Hsu et al, 2021; James & Péault, 2019; Kusumbe et al, 2016). The manipulation of the vasculature is sufficient for the improvement of vascular HSC niche function, which suggests the existence of molecular pathways coupling the behaviour of endothelial cells and perivascular mesenchymal stem progenitor cells (MSPCs) in bone (Hanoun et al, 2014; Ramasamy, 2017).…”

Section: Introductionmentioning

confidence: 99%

Stimulation of NCAM1-14.3.3.ζδ-derived Peptide Interaction Fuels Angiogenesis and Osteogenesis in Ageing

Yesin,

Liu,

Ding

et al. 2024

Preprint

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The skeletal structure and bone marrow endothelium collectively form a critical functional unit essential for bone development, health, and aging. At the core of osteogenesis and bone formation lies the dynamic process of angiogenesis. In this study, we reveal a potent new endogenous anabolic NCAM1-14.3.3.ζδ-derived-Peptide interaction, which stimulates bone angiogenesis and osteogenesis during homeostasis, aging, and age-related bone diseases. Employing high-resolution imaging and inducible cell-specific mouse genetics, our results elucidate the pivotal role of the NCAM1-14.3.3.ζδ-derived-Peptide interaction in driving the expansion of Clec14a+ angiogenic endothelial cells. Notably, Clec14a+ endothelial cells express key osteogenic factors. The NCAM1-14.3.3.ζδ-derived-Peptide interaction in osteoblasts drives osteoblast differentiation, ultimately contributing to the genesis of new bone. Moreover, the NCAM1-14.3.3.ζδ-derived-Peptide interaction leads to a reduction in bone resorption. In age-associated vascular and bone loss diseases, stimulating the NCAM1-14.3.3.ζδ-derived-Peptide interaction not only promotes angiogenesis but also reverses bone loss. Consequently, harnessing the endogenous anabolic potential of the NCAM1-14.3.3.ζδ-derived-Peptide interaction emerges as a promising therapeutic modality for managing age-related bone diseases.

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Divergent effects of distinct perivascular cell subsets for intra‐articular cell therapy in posttraumatic osteoarthritis

Cited by 7 publications

References 45 publications

Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies

Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies

A Novel Burn / Synovectomy Mouse Model for Temporomandibular Joint Osteoarthritis

Stimulation of NCAM1-14.3.3.ζδ-derived Peptide Interaction Fuels Angiogenesis and Osteogenesis in Ageing

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