Diurnal Variation of Plasma Brain‐Derived Neurotrophic Factor (BDNF) in Humans: An Analysis of Sex Differences

Piccinni, Armando; Marazziti, Donatella; Debbio, Alessandro Del; Bianchi, Carolina; Roncaglia, Isabella; Mannari, Claudio; Origlia, Nicola; Dell’Osso, Mario Catena; Massimetti, Gabriele; Domenici, Luciano; Dell’Osso, Liliana

doi:10.1080/07420520802387773

Cited by 106 publications

(85 citation statements)

References 23 publications

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“…Because the storage time of the samples was no longer than 5 years and the subjects were fasting before the samples were taken, we did not expect any influence of these determinants on the BDNF levels in the present study. Diurnal variation has been reported for plasma BDNF levels, but not for serum BDNF levels [33], we also did not expect any influence of diurnal variation on the outcomes of the present study. Despite its limitations, as far as we know, this is the first study that evaluates serum BDNF and EGF levels in patients with schizophrenia with depression compared to not only a healthy control group but a schizophrenia and major depression group.…”

Section: Discussionsupporting

confidence: 55%

Prediction of Depression in Schizophrenia: Can serum Levels of BDNF or EGF Help us?

Yavaşcı¹

2014

J Psychiatry

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Section: Discussionsupporting

confidence: 55%

Prediction of Depression in Schizophrenia: Can serum Levels of BDNF or EGF Help us?

Yavaşcı¹

2014

J Psychiatry

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“…This apparent inconsistency may be explained by the altered platelet function of smokers (Winther and Fornitz, 1999) and the size of the sample that was studied. Platelets represent a major storage site for BDNF in the peripheral blood (Fujimura et al, 2002), while diurnal rhythm BDNF levels were found in plasma but not in serum (Piccinni et al, 2008). Plasma BDNF concentrations significantly decrease with increases in age or weight, whereas platelet or serum levels do not seem to change (Lommatzsch et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males

Suriyaprom¹,

Tungtrongchitr²,

Thawnashom³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic system. We investigated the BDNF levels and biochemical-hematological parameters of smoker and non-smoker groups, and examined the association of the Val66Met BDNF gene polymorphism with BDNF serum levels and cigarette smoking. The study sample comprised 311 Thai volunteers (200 smokers; 111 non-smokers). The levels of serum BDNF and biochemical-hematological parameters were determined. The Val66Met BDNF polymorphism was genotyped by the polymerase chain reaction-restriction fragment length polymorphism technique. The smoker group had significantly higher serum BDNF levels than the non-smoker group (8.3 vs 6.5 ng/mL, P < 0.05). BDNF concentrations correlated positively with hemoglobin, hematocrit, red blood cell count, white blood cell count, platelet count, number of cigarettes smoked, and thiocyanate level (P < 0.05). No association was found between the BDNF Val66Met genotype and the serum BDNF level. The BDNF Val66Met polymorphism was not significantly associated with the smoking status of the Thai males in this study. Cigarette smoking may be one factor that determines the serum BDNF level, but the BDNF Val66Met polymorphism probably does not influence susceptibility to smoking among Thai males.

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“…In healthy males, plasma BDNF follows a circadian rhythm, similarly to cortisol (191): peak in the morning (8:00) and nadir in the night with a minimum between 10:00 pm and midnight (191)(192)(193). Interestingly, this rhythm was significant only in plasma in men; diurnal variation was found neither in plasma BDNF of women, during the menstrual cycle, nor in serum BDNF level in both men and women (192).…”

Section: Pre-analytical Factorsmentioning

confidence: 94%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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Abstract:In the last few years, a growing number of molecules have been associated to an endocrine function of the skeletal muscle. Circulating myokine levels, in turn, have been associated with several pathophysiological conditions including the cardiovascular ones. However, data from different studies are often not completely comparable or even discordant. This would be due, at least in part, to the whole set of situations related to the preparation of the patient prior to blood sampling, blood sampling procedure, processing and/or store. This entire process constitutes the pre-analytical phase. The importance of the preanalytical phase is often not considered. However, in routine diagnostics, the 70% of the errors are in this phase. Moreover, errors during the pre-analytical phase are carried over in the analytical phase and affects the final output. In research, for example, when samples are collected over a long time and by different laboratories, a standardized procedure for sample collecting and the correct procedure for sample storage are acknowledged. In this review, we discuss the pre-analytical variables potentially affecting the measurement of myokines with cardiovascular functions.

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Diurnal Variation of Plasma Brain‐Derived Neurotrophic Factor (BDNF) in Humans: An Analysis of Sex Differences

Cited by 106 publications

References 23 publications

Prediction of Depression in Schizophrenia: Can serum Levels of BDNF or EGF Help us?

Prediction of Depression in Schizophrenia: Can serum Levels of BDNF or EGF Help us?

BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

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