Diurnal Fluctuation and Concordance of Intraocular Pressure in Glaucoma Suspects and Normal Tension Glaucoma Patients

Abstract

The diurnal variation in IOP between the 2 eyes in GS and NTG is largely concordant in approximately 90% of the time.

Correlation between diurnal variation of intraocular pressure, ocular pulse amplitude and corneal structural properties

“…Diurnal variation in IOP measured by GAT was recognized in many studies (10)(11)(12) . Most investigators found rhythmic pressure variation during the day, and the first hours of the morning has often been the time when higher values have been recorded (13)(14) .…”

Normal Pressure Glaucoma

“…32 More recently, these same researchers looked at the diurnal IOP fluctuation in untreated glaucoma suspect (GS) and NTG eyes. 33 They took six IOP measurements from 7 AM to 10 PM to evaluate the concordance of IOP between fellow eyes. The mean absolute IOP difference between eyes was 1.4-1.9 mmHg in the GS eyes and 1.3-1.5 mmHg for the NTG eyes (correlation between fellow NTG eyes, r = 0.81).…”

Glaucoma: an area of darkness

“…Pseudoexfoliation was significantly associated with visual field progression in the EMGT study, but not identified in the OHT studies. 38,39 One long-term study that looked at diurnal IOP swings as an independent variable found that these fluctuations were not an independent risk factor for conversion to POAG. 40 Sleep laboratory experiments show that in all subjects supine and nocturnal IOPs rise, although the swing was lower in eyes with a higher baseline IOP.…”