Diurnal changes in retinal nerve fiber layer thickness with obstructive sleep apnea/hypopnea syndrome

Chirapapaisan, Niphon; Likitgorn, Techawit; Pleumchitchom, Mintra; Sakiyalak, Darin; Banhiran, Wish; Saiman, Manatsawin; Chuenkongkaew, Wanicha

doi:10.18240/ijo.2016.07.07

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…Besides, there was only one previous study on the diurnal variation of RNFL thickness in OSA patients: Chirapapaisn et al. proposed that RNFL thickness in the morning was significantly higher than in the evening in moderate OSA in the diurnal comparison ( 30 ). They speculated that swelling of RNFL might occur secondary to hypoxia episodes, increasing the cerebral spinal fluid pressure, and chronic hypercapnia and subclinical papilledema could only be detected on OCT images.…”

Section: Discussionmentioning

confidence: 99%

Diurnal changes of retinal microvascular circulation and RNFL thickness measured by optical coherence tomography angiography in patients with obstructive sleep apnea–hypopnea

Cai

Liu²,

Zhang³

et al. 2022

Front. Endocrinol.

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PurposeTo evaluate capillaries perfusion and retinal nerve fiber layer (RNFL) thickness diurnal changes of macular/optic disc regions among participants with or without obstructive sleep apnea-hypopnea (OSA) using spectral-domain optical coherence tomography angiography (OCTA).MethodsIn this study, we enrolled a cohort of 35 participants including 14 patients with mild-to-moderate OSA, 12 patients with severe OSA, and 9 healthy individuals. All participants had Berlin questionnaire filled. At 20:00 and 6:30, right before and after the polysomnography examination, a comprehensive ocular examination was conducted. The systemic and ocular clinical characteristics were collected, and OCTA scans were performed repeatedly. Blood flow and RNFL thickness parameters were then exported using built-in software and analyzed accordingly.ResultsAfter sleep, the overall vessel density (VD) variables, especially macular and choriocapillaris VDs, were relatively comparative and stable. One exception was the RPC vessel density at the inside-disc region with a decreasing trend in the mild-to-moderate group (p=0.023). RNFL changes before and after sleep in the nasal-inferior and peripapillary region were statistically significant (p=0.003; p=0.043) among three groups. And multiple testing correction verified the significant difference in diurnal changes between the mild-to-moderate group and the control group in pairwise comparisons (p=0.006; p=0.02).ConclusionsThe changes of imperceptible blood flow and RNFL thickness overnight around optic disc areas could be observed in OSA patients. Despite physiological fluctuations, aberrant diurnal changes might be useful for identifying a decrease in micro-environmental stability associated with the development of various ocular diseases such as glaucoma. Other VD variables, especially macular and choriocapillaris VDs, are relatively stable in eyes of patients having OSA with different severity.

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Section: Discussionmentioning

confidence: 99%