Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography

Ye, Haiyun; Zheng, Ce; Lan, Xiaoping; Zhao, Limin; Qiao, Tong; Li, Xiaoyan; Zhang, Yidan

doi:10.1007/s00417-018-04207-9

Cited by 14 publications

(22 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ere is limited data in the literature concerning the alterations in FAZ or VDs in OSAS. In a very recent study, Ye et al [17] reported a significant decrease in the FAZ of the superficial capillary plexus but a significant increase in the deep capillary plexus after adenoidectomy in children. Regarding these results, we can conclude that quantitative OCT-A parameters reveal macular ischemia at both superficial and deep retinal capillary plexuses, which may play an important role in the pathophysiology of ocular alterations in severe OSAS patients.…”

Section: Discussionmentioning

confidence: 94%

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Uçak

Unver

2020

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. To analyze the effects of obstructive sleep apnea syndrome (OSAS) on ocular parameters and determine the alterations in macular vasculature by optical coherence tomography-angiography (OCT-A) in patients with different stages of OSAS. Methods. All the participants underwent a full ophthalmological examination. Using the macular OCT-A scans, the retinal peripapillary capillary plexus (RPCP), foveal avascular zone (FAZ), and superficial and deep vessel densities were recorded. Results. A total of 77 patients (154 eyes) with OSAS and 27 control cases (54 eyes) were included in this prospective study. Of the OSAS patients, 27 had mild, 24 had moderate, and 26 had severe disease. The intraocular pressure (IOP) values were significantly higher in the severe OSAS group than the control cases (p=0.001). The average retinal nerve fiber layer (RNFL) thickness and the RNFL thickness of the temporal and inferior quadrants were significantly lower in the severe OSAS group compared with the control cases (p<0.05). There was a significant decrease in the mean RPCP values with a significant increase in the FAZ values of OSAS patients compared with the control group (p=0.001). Both the superficial and deep vascular densities were significantly decreased in OSAS patients, being the lowest in the severe OSAS group. Conclusions. Decreased vascular structures and increased FAZ may also be associated with the disease severity in OSAS and may be the main pathophysiological mechanisms in ocular alterations, which should be investigated in further studies.

show abstract

Section: Discussionmentioning

confidence: 94%

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Uçak

Unver

2020

Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…VPI 42 measures the ratio between overall contour length of blood vessel boundaries (Figure 1(d)) and total blood vessel area in the segmented vessel map (Figure 1(b)). VPI can reflect vessel dropout or early ischemia, 39,43 and has been used to quantify OCTA images of DR 43 and SCR.…”

Section: Quantitative Octa Featuresmentioning

confidence: 99%

Quantitative optical coherence tomography angiography: A review

Yao

Alam

et al. 2020

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

As a new optical coherence tomography (OCT) modality, OCT angiography (OCTA) provides a noninvasive method to detect microvascular distortions correlated with eye conditions. By providing unparalleled capability to differentiate individual plexus layers in the retina, OCTA has demonstrated its excellence in clinical management of diabetic retinopathy, glaucoma, sickle cell retinopathy, diabetic macular edema, and other eye diseases. Quantitative OCTA analysis of retinal and choroidal vasculatures is essential to standardize objective interpretations of clinical outcome. Quantitative features, including blood vessel tortuosity, blood vessel caliber, blood vessel density, vessel perimeter index, fovea avascular zone area, fovea avascular zone contour irregularity, vessel branching coefficient, vessel branching angle, branching width ratio, and choroidal vascular analysis have been established for objective OCTA assessment. Moreover, differential artery–vein analysis has been recently demonstrated to improve OCTA performance for objective detection and classification of eye diseases. In this review, technical rationales and clinical applications of these quantitative OCTA features are summarized, and future prospects for using these quantitative OCTA features for artificial intelligence classification of eye conditions are discussed. Impact statement OCT angiography (OCTA) provides a noninvasive method to detect microvascular distortions correlated with eye conditions. Quantitative analysis of OCTA is essential to standardize objective interpretations of clinical outcome. This review summarizes technical rationales and clinical applications of quantitative OCTA features.

show abstract

“…In addition, children with diabetes type 1 have been shown to have significantly different foveal avascular zone perimeters before clinically significant diabetic retinopathy or changes in foveal avascular zone area 5,6 . Optical coherence tomography angiography has also been used to examine pediatric populations afflicted with other diseases like radiation retinopathy, 7 obstructive sleep apnea-hypopnea syndrome, 8 and amblyopia 9 . The use of OCT-A in pediatric populations (including neonates) is expected to rise because of advances in handheld OCT and OCT-A technology 10–12 .…”

mentioning

confidence: 99%

The Impact of Axial Eye Growth on Foveal Avascular Zone Measurements in Children

et al. 2021

View full text Add to dashboard Cite

SIGNIFICANCE Foveal avascular zone (FAZ) area is a frequently used biomarker in diseases impacting the retinal vasculature in pediatric populations. Variation in axial length between individuals results in differences in lateral image scale, which affect the accuracy of FAZ area measurements. Accordingly, changes in axial length over time within individual children would affect estimates of FAZ area change. PURPOSE This study aimed to quantify how changes in axial length over time affect estimates of FAZ area change using optical coherence tomography angiography (OCT-A) images. METHODS Twenty pediatric participants (<18 years old) and 40 adult participants were imaged on Optovue's Avanti system (Fremont, CA) and had axial length measurements acquired at two time points. The FAZ was segmented twice using the OCT-A image at each time point. Foveal avascular zone area was estimated at both time points using the assumed/fixed axial length of the OCT-A device (unscaled) and using the participant's axial length (scaled). Changes in FAZ area over time were compared between the pediatric and adult groups using both unscaled and scaled data. RESULTS The average ± standard deviation follow-up time was 3.35 ± 1.66 years for the pediatric group and 2.90 ± 1.65 years for the adult group. Using unscaled data, FAZ area seemed to decrease between visits in the pediatric group ( P = .004), whereas the FAZ area increased between visits in the adult group ( P = .003). When correctly scaled data were used, the FAZ area still increased between visits for the adult group ( P < .001), although the FAZ area no longer showed a significant change between visits for the pediatric group ( P = .37). When comparing the normalized FAZ area change across visits between unscaled and scaled data, a significant difference was found between the adult and pediatric groups ( P < .001). CONCLUSIONS Scaled data should be used when measuring FAZ area in pediatric populations, especially in longitudinal studies.

show abstract

Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography

Cited by 14 publications

References 26 publications

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Quantitative optical coherence tomography angiography: A review

The Impact of Axial Eye Growth on Foveal Avascular Zone Measurements in Children

Contact Info

Product

Resources

About