Diuretic Effect of Angiotensin in the Chicken.

Langford, Herbert G.; Fallis, Norma

doi:10.3181/00379727-123-31477

Cited by 28 publications

(9 citation statements)

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“…commun.]. In agreement with the finding in the Chilean toad, a higher dose of A N G II infused into the renal portal system of chickens through their leg veins produced diuresis [78].…”

Section: Dipnoanssupporting

confidence: 77%

Endocrine Control of Renal Handling of Solutes and Water in Vertebrates

Nishimura¹

1985

Kidney Blood Press Res

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Hormones influence renal function by both extrarenal and intrarenal mechanisms. Extrarenal mechanisms include the effects through systemic hemodynamic and neural pathways, whereas intrarenal mechanisms can be largely divided into the effects on intrarenal hemodynamics and those on tubular transport epithelia. Neurohypophysial hormones and the renin-angiotensin system appear to act primarily on systemic and preglomerularvasculature in primitive vertebrates, while direct tubular action appears to have evolved at a later stage of phylogeny. Although aldosterone is an essential hormone for fluid mineral balance in mammals, the action of mineralocorticoids on tubular Na transport has not been established in nonmammalian tetrapods. In bony fishes in hyperosmotic environments, cortisol accelerates active Na extrusion from the gill. In contrast, prolactin is important for maintaining low osmotic water permeability of the transport epithelia in fishes in hypoosmotic media. Thus, both function and site of hormone action appear to have changed during the evolution of vertebrates interacting with changing environments, and in response to the demands from other bodily functions. Furthermore, evolution of interactions, at the cellular level, between systemic and locally formed hormones such as prostaglandins, kinins, and perhaps angiotensin may have developed more elaborate controlling systems of renal handling of solutes and water.

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“…commun.]. In agreement with the finding in the Chilean toad, a higher dose of A N G II infused into the renal portal system of chickens through their leg veins produced diuresis [78].…”

Section: Dipnoanssupporting

confidence: 77%

Endocrine Control of Renal Handling of Solutes and Water in Vertebrates

Nishimura¹

1985

Kidney Blood Press Res

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“…The lack of estimation of the exogenous angiotensin II concentration in the peritubu lar capillaries and the inconclusive results of Langford and Fallis [10] were reasons to re peat the previous experiments.…”

Section: Discussionmentioning

confidence: 99%

“…Langford and Fallis [10] used the original Sperber technique to demonstrate the direct renal tubular action of angiotensin II. The higher increase of urine volume and Na+ ex cretion on the infused side was clear in their first series of experiments.…”

Section: Discussionmentioning

confidence: 99%

The Direct Renal Tubular Effect of Angiotensin II in Chicken

Cuypers¹,

McConaghey²,

Steels³

1993

Kidney Blood Press Res

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Taking advantage of the particular renal vascular arrangement in cocks, angiotensin II was injected (0.12-0.96 µg/min) into the portal system of one kidney in order to increase the angiotensin II concentration in the physiological nanomolar range at the level of the renal tubules. Angiotensin II induced an increase in blood pressure of 5% and a bilateral rise in glomerular filtration rate and effective renal plasma flow of 28 and 22%, respectively. The urine volume increased five times on the infused side and three times on the control side. The Na⁺ excretion increased 14 times on the infused side and only seven times on the control side. During angiotensin infusion, the fractional water excretion was 4.9% on the infused side and 2.9% on the control side versus 1.1 and 1.2% during the control period. For the fractional Na⁺ excretion, the respective values were 2 and 1.2% versus 0.2 and 0.2% during the control period. The differences between the two kidneys demonstrate the direct tubular action of angiotensin II, inhibiting the tubular Na⁺ and water reabsorption at physiological nanomolar concentrations. Angiotensin seems thus to play an important intrarenal role.

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“…angiotensin-induced diuresis and natriuresis, which were probably caused by the pressor effect of i.v. angiotensin (Langford & Fallis, 1966) but may have been attributable to a direct action of the hormone on the renal tubules (Peters & Bonjour, 1971). Potassium excretion was more variable but no consistent pattern emerged.…”

mentioning

confidence: 99%

The effects of changes in osmolality and sodium concentration on angiotensin‐induced drinking and excretion in the pigeon

Fitzsimons

Massi

Thornton

1982

The Journal of Physiology

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1. The pigeon drank copiously after a short latency in response to intracerebro‐ventricular (I.C.V.) infusion of angiotensin II dissolved in isotonic NaCl. There were small, insignificant increases in urinary excertion so that the increased water intake caused the pigeon to go into positive fluid balance. Water was chosen in preference to 0·3 M‐NaCl, which was also available to drink in these experiments. 2. I.C.V. infusion of angiotensin dissolved in water, or in isotonic or hypertonic solutions of non‐eletrolytes, or in KCl or CaCl2 resulted in about half the water intake produced by angiotensin dissolved in isotonic NaCl. 3. I.C.V. infusion of hypertonic NaCl alone caused drinking. I.C.V. infusion of angiotensin dissolved in hypertonic NaCl caused an amount of water to be drunk that was a simple addition of the amounts drunk in response to angiotensin dissolved in isotonic NaCl and to the extra amount of NaCl. 4. Drinking in response to I.C.V. infusion of two other dipsogenic peptides, eledoisin and physalaemin, was similarly affected by the composition of the solutions in which they were dissolved. 5. The pigeon also drank in response to intravenous (I.V.) infusion of angiotensin II dissolved in isotonic NaCl. Urine flow and sodium excretion increased markedly so that the pigeons just maintained fluid balance. 6. In contrast to the reduction in intake when angiotensin was infused I.C.V. dissolved in hypertonic non‐electrolytes, I.V. infusions of angiotensin dissolved in hypertonic non‐electrolytes caused enhanced drinking, compared with the corresponding infusions of angiotensin dissolved in isotonic NaCl. 7. Drinking induced by I.V. infusion of angiotensin was little affected by simultaneous I.C.V. infusion of isotonic or hypertonic sucrose, or water, but it was increased by simultaneous I.C.V. infusion of hypertonic NaCl. 8. Drinking responses were partly additive when angiotensin was given by simultaneous I.C.V. and I.V. infusion. 9. The increased urine flow and electrolyte excretion in response to I.V. infusion of angiotensin were little affected by simultaneous I.C.V. infusion of angiotensin. 10. These experiments suggest that in the pigeon there may be separate sets of receptors in the cerebral ventricles for initiating drinking, one set responding to angiotensin, another to hypertonic NaCl. Outside the blood—brain barrier, and accessible to blood‐borne substances, there may also be separate sets of receptors, one set responding to angiotensin, another to increases in effective osmolality of the blood.

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Diuretic Effect of Angiotensin in the Chicken.

Cited by 28 publications

References 0 publications

Endocrine Control of Renal Handling of Solutes and Water in Vertebrates

Endocrine Control of Renal Handling of Solutes and Water in Vertebrates

The Direct Renal Tubular Effect of Angiotensin II in Chicken

The effects of changes in osmolality and sodium concentration on angiotensin‐induced drinking and excretion in the pigeon

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