Diuretic Activity of Ethanolic Root Extract of Mimosa Pudica in Albino Rats

Kalabharathi, H L

doi:10.7860/jcdr/2014/14662.6877

Cited by 2 publications

(3 citation statements)

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“…Regarding the increase in urine output, the difference between the effects of each dose was indicated by the significant increase of Na + , Cl − , and K + excretions when compared with those of the control group. Therefore, the diuretic action of the TTE of AR could be due to its interference with the Na + , K + , and Cl − co-transport carrier in the luminal membrane of the thick ascending limb of the loop of Henle; which is similar to that of furosemide [ 24 ]. Thiazides initially enhance diuresis via inhibition of the kidney Na + –Cl − cotransporter (NCC) [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Diuretic Activity of Compatible Triterpene Components of Alismatis rhizoma

Zhang

Lin

et al. 2017

Molecules

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Alismatis rhizoma (AR), the dried rhizoma of Alisma orientale Juzepzuk (Alismataceae), is a traditional Chinese medicine. AR is an important part of many prescriptions and is commonly used as a diuretic agent in Asia. This study aimed to evaluate the diuretic effects of total triterpene extract (TTE) and triterpene component compatibility (TCC, the mixture of alisol B 23-acetate, alisol B, alisol A 24-acetate, alisol A, and alisol C 23-acetate) of AR in saline-loaded rats. The optimal diuretic TCC of AR was optimized using a uniform design. Different doses (5, 20, and 40 mg/kg) of TTE and TCC groups (N1–N8) were orally administered to rats. Urinary excretion rate, pH, and electrolyte excretion were measured in the urine of saline-loaded rats. Results showed that TTE doses increased urine volume and electrolyte excretion compared with the control group. All uniformly designed groups of TCC also increased urine excretion. In addition, optimal diuretic TCC was calculated (alisol B 23-acetate: alisol B: alisol A 24-acetate: alisol A: alisol C 23-acetate 7.2:0.6:2.8:3.0:6.4) and further validated by saline-loaded rats. This study demonstrated that TTE presented a notable diuretic effect by increasing Na+, K+, and Cl− displacements. The most suitable TTC compatible proportion of alisol B 23-acetate: alisol B: alisol A 24-acetate: alisol A: alisol C 23-acetate for diuretic activity was validated, and triterpenes were the material basis for the diuretic activity of AR.

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Section: Discussionmentioning

confidence: 99%

Diuretic Activity of Compatible Triterpene Components of Alismatis rhizoma

Zhang

Lin

et al. 2017

Molecules

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“…Of these, M. pigra attenuated the development of experimental pulmonary hypertension, M. caesalpiniifolia Benth. induced vasorelaxant and hypotensive effects, and M. pudica , which showed diuretic and saluretic activities . Despite the biological potential evidenced by these studies, another species of interest, M. bimucronata (DC.)…”

Section: Introductionmentioning

confidence: 98%

“…induced vasorelaxant and hypotensive effects, [22] and M. pudica, which showed diuretic and saluretic activities. [23,24] Despite the biological potential evidenced by these studies, another species of interest, M. bimucronata (DC.) Kuntze, popularly known in Brazil as 'maric a' and of natural occurrence on the Brazilian coast, [25][26][27][28][29] has not yet been the subject of any scientific study regarding its possible phytochemical and pharmacological properties.…”

Section: Introductionmentioning

confidence: 99%