Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects

Mrid, Reda Ben; Bouchmaa, Najat; Kabach, Imad; Zouaoui, Zakia; Chtibi, Houda; Maadoudi, Mohammed El; Kounnoun, Ayoub; Cacciola, Francesco; Majdoub, Yassine Oulad El; Mondello, Luigi; Zyad, Abdelmajid; Nhiri, Mohamed

doi:10.3390/molecules27072108

Cited by 17 publications

(16 citation statements)

References 42 publications

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“…Previous works reported some interesting activities displayed by I. viscosa extracts that can corroborate its traditional use. For example, antioxidant, [18–21] antifungal, [22] antibacterial, [21] anti‐inflammatory, [23] hypoglycemic, [19,21] and cytotoxic [21,24–28] effects can be highlighted. The chemical composition for some I. viscosa extracts was reported before, namely the ethanol, methanol, water, and ethyl acetate fractions [19–22,29,30] …”

Section: Introductionmentioning

confidence: 99%

“…The chemical composition for some I. viscosa extracts was reported before, namely the ethanol, methanol, water, and ethyl acetate fractions. [19][20][21][22]29,30] Although I. viscosa has been the subject of some research works, there is still some missing information concerning the species growing in Algeria and its effect on some prevalent human cancer cells. So, in the present article, we aimed to investigate the chemical composition and cytotoxic properties of the I. viscosa extract against human gastric cancer (AGS) and human non-small-cell lung cancer (A549) cell lines due to the high prevalence of cancer from which they originate.…”

Section: Introductionmentioning

confidence: 99%

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Inula viscosa (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines

Rechek

Haouat

Hamaidia

et al. 2023

Chemistry & Biodiversity

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The present study shows the chemical profile and cytotoxic properties of the ethanolic extracts of Inula viscosa from Northeast Algeria. The extract was obtained by maceration using ethanol. Its phenolic profile was determined using ultra-high-performance liquid chromatography coupled with a diode array detector and an electrospray mass spectrometer (UHPLC-DAD-ESI/MS), which allowed the identification and quantification of 17 compounds, 1,5-O-caffeoylquinic acid being the most abundant. The cytotoxic activity was assessed against human gastric cancer (AGS) and human non-small-cell lung cancer (A549) cell lines, whereas ethanolic extract elicited nearly 60 % and 40 % viability loss toward AGS and A549 cancer cells, respectively. Results also showed that cell death is caspase-independent and confirmed the involvement of RIPK1 and the necroptosis pathway in the toxicity induced by the I. viscosa extract. In addition, the ethanolic extract would not provoke morphological traits in the cancer cells. These findings suggest that I. viscosa can be a source of new antiproliferative drugs or used in preparation plant-derived pharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inula viscosa (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines

Rechek

Haouat

Hamaidia

et al. 2023

Chemistry & Biodiversity

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“…Such data are in agreement with previously published data reporting the chemical characterization of such extracts. [30][31][32][33][34][35][36][37][38][39][40][41] Many of these compounds were reported to contribute to several biological properties such as antioxidant, antifungal, antiinflammatory, antimicrobial, cytotoxicity, antiproliferative, and anticancer. [18,30,[40][41][42][43][44][45][46][47][48] Besides, G. alypum is one of the most used plants regions of North Africa for managing several disorders such as, cardiovascular diseases, diabetes, and various cancerous lesions of the stomach and liver.…”

Section: Discussionmentioning

confidence: 99%

“…[30][31][32][33][34][35][36][37][38][39][40][41] Many of these compounds were reported to contribute to several biological properties such as antioxidant, antifungal, antiinflammatory, antimicrobial, cytotoxicity, antiproliferative, and anticancer. [18,30,[40][41][42][43][44][45][46][47][48] Besides, G. alypum is one of the most used plants regions of North Africa for managing several disorders such as, cardiovascular diseases, diabetes, and various cancerous lesions of the stomach and liver. [49] Its extracts have been demonstrated in several studies revealing its wealthy of bioactive compounds, especially phenolics compounds, e.g.…”

Section: Discussionmentioning

confidence: 99%

Biofilm Inhibition of Inula viscosa (L.) Aiton and Globularia alypum L. Extracts Against Candida Infectious Pathogens and In Vivo Action on Galleria mellonella Model

Asraoui,

El Mansouri,

Cacciola

et al. 2023

Advanced Biology

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The increasing importance of fungal infections has fueled the search for new beneficial alternatives substance from plant extracts. The current study investigates the antifungal and antibiofilm activity of Inula viscosa (L.) Aiton and Globularia alypum (L.) leaves extracts against Candida both in vitro and in vivo. The inhibition of planktonic and sessile Candida albicans and Candida glabrata growth using both leaf extracts are evaluated. Moreover; an in vivo infection model using Galleria mellonella larvae; infected and treated with the extracts are performed. All extracts show fungicidal activity; with a minimum fungicidal concentration (MFC) ranging from 128 to 512 µg mL−1 against the two selected strains of Candida. In particular, the best results are obtained with methanolic extract of I. viscosa and G. alypum with an MFC value of 128 µg mL−1. The extracts are capable to prevent 90% of biofilm development at minor concentrations ranging from 100.71 ± 2.49 µg mL−1 to 380.4 ± 0.92 µg mL−1. In vivo, tests on Galleria mellonella larvae show that the extracts increase the survival of the larvae infected with Candida. The attained results reveal that I. viscosa and G. alypum extracts may be considered as new antifungal agents and biofilm inhibiting agents for the pharmaceutical and agro‐food field.

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“…Therefore, it appears that TAEO can influence on cancer cell microenvironment by increasing antioxidant compounds, reducing oxidants, and improving oxidative stress. TAEO probably increases the expression of proapoptotic genes Bim, Bak, or Bax, arrests the cancer cell cycle, and inhibits cancer by producing ROS inflammatory mediators [20,21].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic effects of Trachyspermum ammi and Ferula assafoetida on MCF-7 and MDA-MB-468 breast cancer cell lines

Moulazadeh

Ranjbar

Ardestani

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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Background The induction of oxidative stress is one of the most important cancer etiologies. Plant essential oils contain many effective antioxidant compounds in improving oxidative stress. In the present study, the pharmacological potential of Trachyspermum ammi essential oil (TAEO) and Ferula assafoetida essential oil (FAEO) was compared in oxidative stress improvement and cytotoxic effect. TAEO and FAEO were prepared by Clevenger apparatus, and the medicinal compounds in the essential oils were evaluated by GC–MS assay. The TAEO and FAEO were also evaluated as to their phenolic and flavonoid content, monovalent reducing power, and total radical scavenging activity, respectively, by Folin–Ciocalteu, aluminum chloride, FRAP, and DPPH methods. The cytotoxic effect of the TAEO and FAEO was evaluated by MTT assay on MCF-7 (ER+) and MDA-MB-468 (ER−) breast cancer cell lines. Results The GC–MS analysis indicated that thymol and (E)-Sec-Butyl propenyl disulfide, respectively, were the highest components of TAEO and FAEO. The phenolic content (P < 0.0001), flavonoid content (P < 0.0001), reducing power (P < 0.0001), radical scavenging activity (P < 0.0001), and cytotoxic effect (P < 0.05) of TAEO were significantly higher than FAEO. The IC50 value of the cytotoxic effect of TAEO on MCF-7 and MDA-MB-468 after 72 h of incubation was, respectively, 192.5 ± 42.57 and 331.4 ± 7.24 ppm. Conclusion The cytotoxic effect of TAEO was more potent on the MCF-7 cell line, probably in an estrogen-dependent manner of cellular growth inhibition. It appears that TAEO has a high capacity for improving oxidative stress and inhibiting cell proliferation in breast cancer.

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Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects

Cited by 17 publications

References 42 publications

Inula viscosa (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines

Inula viscosa (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines

Biofilm Inhibition of Inula viscosa (L.) Aiton and Globularia alypum L. Extracts Against Candida Infectious Pathogens and In Vivo Action on Galleria mellonella Model

Cytotoxic effects of Trachyspermum ammi and Ferula assafoetida on MCF-7 and MDA-MB-468 breast cancer cell lines

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