Diterpenoids of terrestrial origin

Hanson, James R.

doi:10.1039/c6np00059b

Cited by 51 publications

(13 citation statements)

References 207 publications

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“…The triterpene T14 , isolated from a fungal source (mushroom) Ganoderma colossum , showed inhibition activity against HIV-1 protease enzyme (EC50 = 15.3 μM) [33] . The diterpenoids T16 , micafungin, found in fungal cell walls, is available in market as the intravenous antifungal drug [34] . The source and activities of all other NPs are given in the Table S1.…”

Section: Resultsmentioning

confidence: 99%

Anti-COVID-19 terpenoid from marine sources: A docking, admet and molecular dynamics study

Sepay

Sekar²,

Halder

et al. 2021

Journal of Molecular Structure

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Highlights Screening more than fifty natural products for the SARS CoV-2 M pro protein target The compounds with higher hydrophobicity and lower flexibility can be more favorable inhibitor Terpenoid from marine sponge Cacospongia mycofijiensis shows excellent SARS CoV-2 M pro inhibitory activity In the point of binding affinity, bioavailability, pharmacokinetics and toxicity, the natural product can act as a potential drug candidate against COVID-19 virus.

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Section: Resultsmentioning

confidence: 99%

Anti-COVID-19 terpenoid from marine sources: A docking, admet and molecular dynamics study

Sepay

Sekar²,

Halder

et al. 2021

Journal of Molecular Structure

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“…According to Peters, 16 halimanes are found within the labdane and clerodane group, as indicated in the general biogenetic scheme (Scheme 1). The halimane-type carbocation can be in position 10 leading to D 1 (10) or D 5 (10) halimanes or in position 5, due to a hydride 1,2-shi, leading to D 5 halimanes. Other halimanes can be understood from these intermediates or derivatives, as reported later on.…”

Section: Introductionmentioning

confidence: 99%

Halimane diterpenoids: sources, structures, nomenclature and biological activities

et al. 2018

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Covering: 1970 to 2017 Diterpenes with a halimane skeleton constitute a small group of natural products that can be biogenetically considered as being between labdane and clerodane diterpenoids. Some of these compounds show biological activities, such as antitumour, mosquito repellency, germination inhibition and antimicrobial, as well as being biomarkers for tuberculosis. To the best of our knowledge, there are no reviews on these compounds. In this review, halimane skeleton diterpenoids are classified according to their biogenetic origin, characterization and/or the enzymes involved in their biosynthesis. Herein, a review of their synthesis or synthetic approaches is communicated.

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“…In turn, terpenoids are categorized into monoterpenes, sesquiterpenes, diterpenes, sesterpenes, and triterpenes depending on the number of their isoprene units. Diterpenes constitute a diverse class of plant metabolites with more than 10,000 different structures, isolated in the Lamiaceae present about 50 different skeletons [ 89 , 90 ]. Most diterpenes play a critical role in ecological interactions of plants and show interesting biological activities both in vitro and in vivo [ 91 , 92 ], such as antibacterial, antifungal, antiprotozoal, enzyme-inducing, anti-inflammatory, and the modulation of immune cell function and anticancer properties [ 92 , 93 ].…”

Section: The Lamiaceae Family Plantsmentioning

confidence: 99%

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

Sitarek

Merecz-Sadowska

Śliwiński

et al. 2020

Cancers

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It is predicted that 1.8 million new cancer cases will be diagnosed worldwide in 2020; of these, the incidence of lung, colon, breast, and prostate cancers will be 22%, 9%, 7%, and 5%, respectively according to the National Cancer Institute. As the global medical cost of cancer in 2020 will exceed about $150 billion, new approaches and novel alternative chemoprevention molecules are needed. Research indicates that the plants of the Lamiaceae family may offer such potential. The present study reviews selected species from the Lamiaceae and their active compounds that may have the potential to inhibit the growth of lung, breast, prostate, and colon cancer cells; it examines the effects of whole extracts, individual compounds, and essential oils, and it discusses their underlying molecular mechanisms of action. The studied members of the Lamiaceae are sources of crucial phytochemicals that may be important modulators of cancer-related molecular targets and can be used as effective factors to support anti-tumor treatment.

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Diterpenoids of terrestrial origin

Abstract: This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products. There are 214 references.

Cited by 51 publications

References 207 publications

Anti-COVID-19 terpenoid from marine sources: A docking, admet and molecular dynamics study

Anti-COVID-19 terpenoid from marine sources: A docking, admet and molecular dynamics study

Halimane diterpenoids: sources, structures, nomenclature and biological activities

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

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