Diterpenoids fromMarrubium peregrinum. I

Salei, L. A.; Popa, D. P.; Lazur'evskii, G. V.

doi:10.1007/bf00564089

Cited by 10 publications

(19 citation statements)

References 2 publications

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“…The essential oil of M. peregrinum revealed the presence ofphellandrene, epi-bicyclosesquiphellandrene and bicyclogermacrene as the major compounds in a sample collected in Greece, while a sample from Central Europe was rich in -caryophyllene and its oxide, bicyclogermacrene and germacrene D [56,57].…”

Section: Marrubium Peregrinum Lmentioning

confidence: 98%

“…Phenolic compounds are predominant in this species, such as flavone aglycones, flavone glycosides, coumaroylated flavone glycosides and acteoside-related phenylethanoids. The following compounds are described: four diterpenoids: peregrinine (40), peregrinol (19), marrubiin (9) and premarrubiin (62) [51,52] and six phenolic compounds: 4',5,6,7-tetramethoxyflavone (63) [53], apigenin (4), kaempferol (64), apigenin-7-O-glucoside (5), luteolin-7-O-glucoside (24) and acteoside (12) [54,55].…”

Section: Marrubium Peregrinum Lmentioning

confidence: 99%

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A Review of the Chemical and Pharmacological Aspects of the Genus Marrubium

Meyre‐Silva¹,

Cechinel‐Filho

2010

CPD

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The genus Marrubium (Lamiaceae) is comprised of about forty species, distributed in Europe, Asia and Brazil. Some species are traditionally used to treat various diseases, including asthma, pulmonary infections, inflammation and hypotension, as cholagogues and sedative agents, and for pain relief. A literature review on the chemical and biological aspects of these plants indicates antimicrobial activity against gram positive bacteria, analgesic properties, and anti-hypertensive, antidiabetic, antioxidant properties, among others, particularly related to the presence of diterpenes, sterols, phenylpropanoids and flavonoids. This review shows the main chemical and pharmacological aspects of the genus Marrubium, with emphasis on M. vulgare, which grows in Brazil and has been studied by us and other authors.

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Section: Marrubium Peregrinum Lmentioning

confidence: 98%

Section: Marrubium Peregrinum Lmentioning

confidence: 99%

A Review of the Chemical and Pharmacological Aspects of the Genus Marrubium

Meyre‐Silva¹,

Cechinel‐Filho

2010

CPD

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“…It seems that M. thessalum produces mainly compounds which have a C(3)-oxygenation pattern, like M. peregrinum [20], M. incanum [21], M. friwaldskyanum [22], and M. velutinum [6]. In contrast, a large number of other species of the genus Marrubium produce metabolites which lack an O-function at C(3).…”

mentioning

confidence: 88%

“…(18), and C(3), C(4), and C (19) and between those of Me (20), and C(9) and C(10) enabled the establishment of the skeleton of decalin. HMBC Spectra were also helpful in the identification of the ketone C¼O group at C(3) (d(C) 205.8/205.8, 1 and 2, resp.)…”

mentioning

confidence: 96%

Minor Labdane Diterpenes from Marrubium thessalum

Argyropoulou

Karioti

Skaltsa

2011

Chemistry & Biodiversity

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Five new labdane diterpenes, thessalines A, B, and D, 14β-hydroxythessaline A, and 14β-hydroxythessaline B (1-5, resp.) were isolated from the aerial parts of Marrubium thessalum, along with the known labdane diterpene deacetylvitexilactone (6) and the methoxylated flavones 4',7-dimethylapigenin and salvigenin. (3S,5R)-Loliolide was also found in the same source. Their structures were established by 1D- and 2D-NMR (COSY, HSQC, HMBC, NOESY, and ROESY) and MS analyses. The plant produces a great variety of labdane-type diterpenes, with variations in functionalities, particularly in the side chain. Their structures could be of chemotaxonomic significance for the genus Marrubium.

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“…), flavonols (kaempferol) [62], [63], caffeic acid derivatives [64], and four diterpenoids (peregrinin, peregrinol, marrubiin and premarrubiin) [65]. T. Hennebelle et al [66] Marrubium peregrinum essential oil yield between 0.02-0.07% [67].…”

Section: Horehound (Marrubium Peregrinum L)mentioning

confidence: 99%